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2020 Frontiers in Integrative Neuroscience
Experimental Study GB20 Eye Diseases Multiple Sclerosis Acupuncture
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Presentation Slides
Chinese Medicine Research Hub
Experimental Study
Needling at the GB20 acupoint in Traditional Chinese Medicine can reverse the expression of certain genes related to axon development and regeneration in optic neuritis.
2020 Frontiers in Integrative Neuroscience Effects of Retinal Transcription Regulation After GB20 Needling Treatment in Retina With Optic Neuritis
Chen J, Zhang L, Gan X, Zhang R, He Y, Lv Q, Fu H, Liu X, Miao L
Executive Summary
Write an executive summary in the form of a blog article on the topic of "Research into Chinese medicine treatment for Optic Neuritis" summarising the research below and using language that can be easily understood by patients and avoiding medical jargon using a professional and caring tone of voice.
Write an executive summary in the form of a blog article on the topic of "Researched Chinese medicine treatments for Optic Neuritis" summarising the research below in an objective and easy to understand way, and using language that can be easily understood by patients. Group the article into Chinese medicine treatments first, followed by nutrition and other treatments. Avoid using medical jargon and use a professional and caring tone of voice.
Write me a concise but easy to understand executive summary on the topic of "Chinese medicine treatments for Optic Neuritis" based on the following research that I will give you. Your summary should be 2 paragraphs long in Australian English spelling and include references to the studies.
A Experimental Study published in 2020 in the journal Frontiers in Integrative Neuroscience found that Needling at the GB20 acupoint in Traditional Chinese Medicine can reverse the expression of certain genes related to axon development and regeneration in optic neuritis. To explore the molecular mechanisms of GB20 acupoint needling treatment on Optic Neuritis, a common symptom of Multiple Sclerosis, an Experimental Autoimmune Encephalomyelitis (EAE) mouse model with EAE-associated optic neuritis was utilized. Traditional Chinese Medicine practices of needling at the GB20 acupoint and GV16 acupoint control treatment were applied, followed by RNA sequencing of the retinal transcriptome to identify differentially expressed genes.
In the discussion of the results, it was found that of the genes affected by optic neuritis, needling at the GB20 acupoint reversed the expression of 21 genes, including Nr4a3, Sncg, Uchl1, and Tppp3. These genes are particularly involved in axon development and regeneration, suggesting a beneficial effect from GB20 acupoint needling. Moreover, it was discovered that GB20 needling also influenced the circadian rhythm in the mouse retina with optic neuritis. The GV16 was also identified to be an effective control site for GB20 treatment in animal studies.
