Tian Ma

Gastrodia elata Blume Polysaccharides: A Review of Their Acquisition, Analysis, Modification, and Pharmacological Activities

2019 Jul 02   Molecules   Zhu H, Liu C, Hou J, Long H, Wang B, Guo D, et al.

In summary, many new ideas and techniques have been developed for the study of polysaccharides in traditional Chinese medicine. However, the extraction, analysis, and derivatization of G. elata polysaccharides are still conducted using traditional methods. Consequently, G. elata polysaccharides have not been fully studied. There is still much room for deeper research. New extraction, analysis, and derivatization research methods should be applied to the study of G. elata polysaccharides to further discover its potential bioactivity, functions, and applications.

Traditional Chinese herbal formula relieves snoring by modulating activities of upper airway related nerves in aged rats

2018 May   Drug Design, Development and Therapy   Chung KT, Hsu CH, Lin CL, Wang SE, Wu CH

Analytical Techniques and Pharmacokinetics of Gastrodia elata Blume and Its Constituents

2017 Jul 08   Molecules   Wu J, Wu B, Tang C, Zhao J

Although G. elata has been used for thousands of years in China, the lack of standardization and safety and efficacy studies vastly restricts its utilization worldwide. Since ancient times, GAS and HBA have been widely considered to be the major bioactive constituents or metabolites of G. elata in vivo. With phytochemical studies, more constituents, such as parishins and hydroxybenzyl nucleosides, have been reported to exert a greater potential effect. However, there are still multiple complications that needs to be considered such as chemical properties and utilizing for the public before further application can occur.

Gastrodia elata and epilepsy: Rationale and therapeutic potential

2016 Nov   Phytomedicine   Matias M, Silvestre S, Falcão A, Alves G

Due to its recognised therapeutic properties, G. elata has gained an increasing interest within the scientific community and, therefore, new medicinal preparations containing G. elata rhizome itself or its bioactive components are expected to be developed in the coming years. Moreover, specific phytochemical constituents isolated from G. elata may also be considered to integrate programs of discovery and development of new anticonvulsant drug candidates.

Neuropharmacological Potential of Gastrodia elata Blume and Its Components

2015 Jan   Evidence-Based Complementary and Alternative Medicine   Jang JH, Son Y, Kang SS, Bae CS, Kim JC, Kim SH, et al.

In this review, we summarized the protective effects of GE against neurodegenerative disorders and proposed the underlying mechanisms of the neuropharmacological potential of GE and its components. In addition, we confirmed that administration of vanillin, an active component of GE, ameliorates TMT-induced seizures, which may be related to the reduced neuronal death and microglial activation. Therefore, this review encourages the identification of specific GE components for use in possible preventive or therapeutic strategies for various neurodegenerative disorders and may also be helpful for the development of new treatments for incurable disorders.

Gastrodia elata Blume Polysaccharides: A Review of Their Acquisition, Analysis, Modification, and Pharmacological Activities

2019 Jul 02   Molecules   Zhu H, Liu C, Hou J, Long H, Wang B, Guo D, et al.

In summary, many new ideas and techniques have been developed for the study of polysaccharides in traditional Chinese medicine. However, the extraction, analysis, and derivatization of G. elata polysaccharides are still conducted using traditional methods. Consequently, G. elata polysaccharides have not been fully studied. There is still much room for deeper research. New extraction, analysis, and derivatization research methods should be applied to the study of G. elata polysaccharides to further discover its potential bioactivity, functions, and applications.

Analytical Techniques and Pharmacokinetics of Gastrodia elata Blume and Its Constituents

2017 Jul 08   Molecules   Wu J, Wu B, Tang C, Zhao J

Although G. elata has been used for thousands of years in China, the lack of standardization and safety and efficacy studies vastly restricts its utilization worldwide. Since ancient times, GAS and HBA have been widely considered to be the major bioactive constituents or metabolites of G. elata in vivo. With phytochemical studies, more constituents, such as parishins and hydroxybenzyl nucleosides, have been reported to exert a greater potential effect. However, there are still multiple complications that needs to be considered such as chemical properties and utilizing for the public before further application can occur.

Gastrodia elata and epilepsy: Rationale and therapeutic potential

2016 Nov   Phytomedicine   Matias M, Silvestre S, Falcão A, Alves G

Due to its recognised therapeutic properties, G. elata has gained an increasing interest within the scientific community and, therefore, new medicinal preparations containing G. elata rhizome itself or its bioactive components are expected to be developed in the coming years. Moreover, specific phytochemical constituents isolated from G. elata may also be considered to integrate programs of discovery and development of new anticonvulsant drug candidates.

Neuropharmacological Potential of Gastrodia elata Blume and Its Components

2015 Jan   Evidence-Based Complementary and Alternative Medicine   Jang JH, Son Y, Kang SS, Bae CS, Kim JC, Kim SH, et al.

In this review, we summarized the protective effects of GE against neurodegenerative disorders and proposed the underlying mechanisms of the neuropharmacological potential of GE and its components. In addition, we confirmed that administration of vanillin, an active component of GE, ameliorates TMT-induced seizures, which may be related to the reduced neuronal death and microglial activation. Therefore, this review encourages the identification of specific GE components for use in possible preventive or therapeutic strategies for various neurodegenerative disorders and may also be helpful for the development of new treatments for incurable disorders.