Functional Dyspepsia

Presentation Slides

Chinese Medicine Research Hub

Systematic Review

Menthacarin, derived from peppermint and caraway oil, effectively reduces symptoms, offers a safe alternative to risky drugs like cisapride, and shows promise for managing stomach problems in primary care.

2022 Digestive Diseases Menthacarin, a proprietary peppermint oil and caraway oil combination, improves multiple complaints in patients with functional gastrointestinal disorders – a systematic review and meta-analysis
Madisch A, Frieling T, Zimmermann A, Hollenz M, Labenz J, Stracke B, Miehlke S

Chinese Medicine Research Hub

Systematic Review

Chinese herbal medicine shows promising and safe outcomes in relieving functional dyspepsia symptoms and associated psychological disorders.

2022 Frontiers in Neuroscience Chinese Herbal Medicine for Functional Dyspepsia With Psychological Disorders: A Systematic Review and Meta-Analysis
Luo X, Wang L, Fang S, Qing X, Jiang T, Yang Y, Su X, Wei W

Chinese Medicine Research Hub

Systematic Review

Xiao Yao San can improve symptoms and reduce recurrence rates in patients with disorders of gut-brain interaction.

2022 Frontiers in Pharmacology Efficacy and Safety of Chinese Herbal Medicine Xiao Yao San in Functional Gastrointestinal Disorders: A meta-Analysis and Trial Sequential Analysis of Randomized Controlled Trials
Liu Q, Shi Z, Zhang T, Jiang T, Luo X, Su X, Yang Y and Wei W

Chinese Medicine Research Hub

Randomised Controlled Trial

Jia Wei Xiao Yao Wan showed an improvement in gastrointestinal symptoms for patients with functional dyspepsia who resisted conventional treatments.

2020 Clinical and Translational Gastroenterology An Herbal Formulation of Jiawei Xiaoyao for the Treatment of Functional Dyspepsia: A Multicenter, Randomized, Placebo-Controlled, Clinical Trial
Chen G, Feng P, Wang S, Ding X, Xiong J, Wu J, Wang L, Chen W, Chen G, Han M, Zou T, Li L, Du H

Chinese Medicine Research Hub

Positive effects of acupuncture and electroacupuncture were observed in regulating gastric motility, gastric accommodation, mental status, gastrointestinal hormones, and central and autonomic functions while improving dyspeptic symptoms and quality of life.

2020 World Journal of Gastroenterology Effects and mechanisms of acupuncture and electroacupuncture for functional dyspepsia: A systematic review
Guo Y, Wei W, Chen JD

Chinese Medicine Research Hub

Systematic Review

A combination of peppermint oil and caraway oil is an effective and safe short-term treatment for functional dyspepsia.

2019 Evidence-Based Complementary and Alternative Medicine A Combination of Peppermint Oil and Caraway Oil for the Treatment of Functional Dyspepsia: A Systematic Review and Meta-Analysis
Juanjuan Li, Lin Lv, Jiaqi Zhang, Lin Xu, Enjin Zeng, Zedan Zhang, Fengyun Wang, Xudong Tang

Chinese Medicine Research Hub

Systematic Review

Acupuncture was superior to either sham acupuncture or medication (including Itopride, Mosapride, and Domperidone) in relieving the major symptoms of functional dyspepsia.

2016 Evidence-Based Complementary and Alternative Medicine Acupuncture for Functional Dyspepsia: What Strength Does It Have? A Systematic Review and Meta-Analysis of Randomized Controlled Trial
Bo Pang, Tao Jiang, Yuan-Hao Du, Jing Li, Bo Li, Ya-Cai Hu, Qiu-Han Ca

Chinese Medicine Research Hub

Clinical Study

Drinking hydrogen carbonate-rich mineral water significantly reduces heartburn episodes and improves quality of life in individuals with dyspeptic symptoms.

2016 Open Journal of Gastroenterology Pilot Trial on the Efficacy and Safety of a Natural Mineral Water Rich in Hydrogen Carbonate on Functional Dyspepsia and Heartburn
Pohl U, Auinger A, Bothe G, Uebelhack R

Executive Summary

Write an executive summary in the form of a blog article on the topic of "Research into Chinese medicine treatment for Functional Dyspepsia" summarising the research below and using language that can be easily understood by patients and avoiding medical jargon using a professional and caring tone of voice.

Write an executive summary in the form of a blog article on the topic of "Researched Chinese medicine treatments for Functional Dyspepsia" summarising the research below in an objective and easy to understand way, and using language that can be easily understood by patients. Group the article into Chinese medicine treatments first, followed by nutrition and other treatments. Avoid using medical jargon and use a professional and caring tone of voice.

Write me a concise but easy to understand executive summary on the topic of "Chinese medicine treatments for Functional Dyspepsia" based on the following research that I will give you. Your summary should be 2 paragraphs long in Australian English spelling and include references to the studies.

A Systematic Review published in 2022 in the journal Digestive Diseases found that Menthacarin, derived from peppermint and caraway oil, effectively reduces symptoms, offers a safe alternative to risky drugs like cisapride, and shows promise for managing stomach problems in primary care. Menthacarin works well in reducing symptoms like pain and bloating. It is safe and could be an alternative to other drugs like cisapride, which can be risky. This herbal treatment seems useful for stomach problems in primary care, but more research is needed. In short, Menthacarin, made from peppermint and caraway oil, is a safe and effective option for stomach issues in primary care.

A Systematic Review published in 2022 in the journal Frontiers in Neuroscience found that Chinese herbal medicine shows promising and safe outcomes in relieving functional dyspepsia symptoms and associated psychological disorders. The methodology for this research involved a comprehensive search across various libraries and databases, such as PubMed, Embase, Cochrane Library, Web of Science, and various Chinese data sources, seeking randomized controlled trials where functional dyspepsia was treated with Chinese herbal medicine. The aim was to assess the efficacy and safety of this type of treatment for functional dyspepsia. Two researchers independently conducted each stage of the process, from searching the sources, screening the documents, extracting data, and assessing risk biases within the included studies. They used RevMan 5.4 software to do a meta-analysis of the selected research materials. The discussion of their findings showed that treatment with Chinese herbal medicine significantly alleviated the symptoms of functional dyspepsia, compared to both a placebo group and a group treated with traditional prokinetic agents and flupentixol melitracen. Patients treated with Chinese herbal medicine reported higher total effective rates and lower total symptom scores, along with smaller depression and anxiety scores. The symptoms of functional dyspepsia, in this case, were improved more successfully with Chinese herbal medicine than with other treatment types, without any significant adverse reactions.

A Systematic Review published in 2022 in the journal Frontiers in Pharmacology found that Xiao Yao San can improve symptoms and reduce recurrence rates in patients with disorders of gut-brain interaction. The paper's methodology involved a meta-analysis of randomized controlled trials found in seven databases, up until November 22, 2021. The trials, which totaled 48 all together, were included to determine the efficacy of Xiao-Yao-San in treating disorders of gut-brain interaction (previously known as functional gastrointestinal disorders). A range of measures, including therapeutic efficacy, symptom score, Self-Rating Anxiety Scale score, Self-Rating Depression Scale score, and the recurrence rate, were analysed using both random-effects and fixed-effects models, as well as trial sequential analysis. In terms of results, Xiao-Yao-San showed a marked improvement in the effective rate of managing disorders of gut-brain interaction compared to western drugs, both when used alone and in combination with western medicine. The paper also found the treatment notably reduced symptom scores, anxiety scores, and depression scores for patients with the disorder. Further, instances of recurrence were also reduced. Overall, Xiao-Yao-San was well tolerated and no serious adverse events were reported in any of the trials included in this analysis.

A Randomised Controlled Trial published in 2020 in the journal Clinical and Translational Gastroenterology found that Jia Wei Xiao Yao Wan showed an improvement in gastrointestinal symptoms for patients with functional dyspepsia who resisted conventional treatments. The researchers approached 144 individuals who had functional dyspepsia and had previously rejected standard therapies like proton pump inhibitors, H2 blockers, and Helicobacter pylori collision treatment. These individuals, located across nine different sites in China, were randomly selected to either a Jiawei Xiaoyao pill or a placebo, which they had to take for four weeks. The main measurement used in the study was the change in the individuals' total Gastrointestinal Symptom Score from the beginning of the test period to the end. Additionally, the team used the results of various medical tests for safety outcomes. Out of 141 patients that qualified for statistical analysis, the group taking the Jiawei Xiaoyao pill demonstrated a more significant decrease in their Gastrointestinal Symptom Score compared to the ones on placebo, suggesting the pill was beneficial for their symptoms. However, the Jiawei Xiaoyao pill group did not show a significant improvement in their Hamilton Depression Scale or Hamilton Anxiety Scale scores, suggesting the pill might not have significant impact on depression or anxiety. The total number of adverse events reported were more in the Jiawei Xiaoyao pill group than the placebo group. But the superiority of the Jiawei Xiaoyao pill in improving gastrointestinal symptoms in functional dyspepsia patients that resist standard therapies is evident.

A published in 2020 in the journal World Journal of Gastroenterology found that Positive effects of acupuncture and electroacupuncture were observed in regulating gastric motility, gastric accommodation, mental status, gastrointestinal hormones, and central and autonomic functions while improving dyspeptic symptoms and quality of life. In this systematic review, we pooled randomized controlled trials with mechanistic investigations of acupuncture or electroacupuncture in improving dyspeptic symptoms, and illustrated the existing results that may provide potential explanations for the therapeutic effects. The findings of included studies in this review suggest that acupuncture and electroacupuncture can improve gastric motility and accommodation, regulate gastrointestinal hormones and mental status, and alter certain central and autonomic functions in patients with functional dyspepsia. However, due to limitations in the included articles, high-quality studies with well-planned designs and multiregional investigations are necessary to provide more convincing and credible evidence.

A Systematic Review published in 2019 in the journal Evidence-Based Complementary and Alternative Medicine found that A combination of peppermint oil and caraway oil is an effective and safe short-term treatment for functional dyspepsia. It is the first attempt to generate RCT data of peppermint oil and caraway oil (POCO) for the treatment of functional dyspepsia. In this meta-analysis, we evaluated the efficacy and safety of POCO based on five RCTs with 578 patients. The results demonstrated that POCO can significantly improve global symptoms of FD, with an NNT of 3 when data from four studies were pooled. The positive and significant efficacy in terms of improvement in epigastric pain was also shown between the two studies. Moreover, the available data have found that the safety profile of POCO is similar to placebo. The strength of our findings is that no significant heterogeneity was detected across the studies. Besides, study designs of the included trials were fairly similar and the duration of treatment was identical. We used rigorous methodology as follows and believe that the results reflect the best available current evidence. Firstly, our literature search was comprehensive including all RCTs regardless of publication type and language. Besides, we adopted the intention-to-treat analysis on all data to enhance the robustness of the results.

A Systematic Review published in 2016 in the journal Evidence-Based Complementary and Alternative Medicine found that Acupuncture was superior to either sham acupuncture or medication (including Itopride, Mosapride, and Domperidone) in relieving the major symptoms of functional dyspepsia. Acupuncture therapy (including manual and electroacupuncture) achieved statistically significant effect in improving the overall symptoms and quality of life of functional dyspepsia patients comparing to sham acupuncture and is superior to medication (prokinetic agents) in ameliorating the major symptoms of functional dyspepsia (postprandial fullness and early satiation).

A Clinical Study published in 2016 in the journal Open Journal of Gastroenterology found that Drinking hydrogen carbonate-rich mineral water significantly reduces heartburn episodes and improves quality of life in individuals with dyspeptic symptoms. This one-arm pilot study involved 56 men and women experiencing frequent heartburn. Participants were instructed to drink 1.5 liters of mineral water high in hydrogen carbonate daily for six weeks. They kept a daily diary to record the number and duration of heartburn episodes. Additionally, several questionnaires were used to assess the effects of the water on their condition and quality of life. These included the Reflux Disease Questionnaire (RDQ), Quality of Life in Reflux and Dyspepsia questionnaire (QOLRAD), Gastrointestinal Quality of Life Index (GILQI), and the Short Form Health Survey (SF-12). The study analyzed changes in symptoms and quality of life before and after the treatment using the Wilcoxon test. The study reported a significant decrease in the number of weekly heartburn episodes and the duration of each episode after the six-week intervention. Participants also experienced a notable reduction in the severity of heartburn, regurgitation, and dyspeptic complaints. There was a significant improvement in disease-specific quality of life as measured by GILQI and QOLRAD, and in general health-related quality of life as assessed by SF-12. These findings suggest that drinking hydrogen carbonate-rich mineral water can be an effective alternative treatment for dyspeptic symptoms and heartburn, leading to an enhanced quality of life.

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