Menstrual Disorder
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Research Articles
Published research studies are articles that present the findings of original research that has undergone a peer-review process and has been made publicly available in scholarly journals, books or other media.
Elucidation of the Effects of Si-Wu Tang on Menstrual Disorder Patterns through Activation of Aromatase and Antioxidation
2022 Jan Frontiers in Pharmacology Guan-Cheng Huang, Yi-Zhe Tsai, Chia-Jung Lee, Heng-Yu Chang, Ching-Chiung Wang
Experimental Study Women's Health Shao Yao Si Wu Tang Oestradiol Shu Di HuangSi Wu Tang has improved menstrual symptoms by increasing estradiol content and antioxidative effects as a result of its herbs' synergistic relationships.
Effect of Wenshentiaojing Decoction on Hormone Level and Follicular Number in Patients with Menstrual Disorder of Polycystic Ovary Syndrome
2021 Nov 29 Evidence-Based Complementary and Alternative Medicine Li L, Huang N, Qi Y, Li Y, Wang L
Randomised Controlled TrialThe Treatment with Complementary and Alternative Traditional Chinese Medicine for Menstrual Disorders with Polycystic Ovary Syndrome
2021 May 17 Evidence-Based Complementary and Alternative Medicine Zhang Y, Guo X, Ma S, Ma H, Li H, Wang Y, et al.
For PCOS menstrual disorders, TCM and acupuncture are the most commonly used CAM methods, but other CAM medicine therapies also help improve PCOS menstrual disorders.
Review Article PCOS
Uncovering the pharmacological mechanism of motherwort (Leonurus japonicus Houtt.) for treating menstrual disorders: A systems pharmacology approach
2020 Dec Computational Biology and Chemistry Wang C, Lv X, Liu W, Liu S, Sun Z
Most of the bioactive components in motherwort had good binding ability with these genes, implying that motherwort could regulate their biological function. Collectively, this study elucidated the molecular mechanisms that underlay the efficiency of motherwort against MDs and demonstrated the potential of network pharmacology as an approach to uncover the action mechanism of herbal medicines.
Network Pharmacology Yi Mu Cao Menstrual Disorder
Acupoint stimulation and Chinese herbal medicines for the treatment of premature ovarian insufficiency: A systematic review and meta-analysis
2020 Nov Complementary Therapies in Medicine Li Y, Xia G, Tan Y, Shuai J
Systematic Review Meta-Analysis Ovarian InsufficiencyIn a meta-analysis of 14 trials with 1030 women, acupoint stimulation and Chinese Herbal Medicine were effective in improving menstrual cycles, perimenopausal symptoms, and sex hormone levels in comparison to Hormone Replacement Therapy.
Research Insights
Insights are moderated by the Research Hub team and offer an at-a-glance overview of interesting research findings.
Si Wu Tang has improved menstrual symptoms by increasing estradiol content and antioxidative effects as a result of its herbs' synergistic relationships.
2022 Frontiers in Pharmacology Elucidation of the Effects of Si-Wu Tang on Menstrual Disorder Patterns through Activation of Aromatase and Antioxidation Guan-Cheng Huang, Yi-Zhe Tsai, Chia-Jung Lee, Heng-Yu Chang, Ching-Chiung Wang
Experimental Study Oestradiol Shao Yao Shu Di Huang
In the methodology of the study, a testosterone-treated MCF-7 cell model was employed to determine the effects of each herb in the SWT formula. Key metrics that were considered included the regulation of estradiol, antioxidative effects, and the total polyphenol and polysaccharide contents as quality markers. The study also explored the potential ability of certain elements within the formula to act as an aromatase promoter, notably catalpol and other elements.
In terms of results, certain herbs in SWT such as catalpol showed an ability to significantly increase estradiol content and boost upregulation in cell culture, indicating their role as potential aromatase promoters within the formula. Antioxidant activity was also strong in other compounds like pentagalloylglucose, gallic acid, and ferulic acid. These antioxidative effects were attributed to the presence of polyphenols in the herbs. Furthermore, the herb with the strongest antioxidant effects could possibly help ameliorate menstrual disorder patterns due to its ability to prevent ROS damage to the ovaries.
In a meta-analysis of 14 trials with 1030 women, acupoint stimulation and Chinese Herbal Medicine were effective in improving menstrual cycles, perimenopausal symptoms, and sex hormone levels in comparison to Hormone Replacement Therapy.
2020 Complementary Therapies in Medicine Acupoint stimulation and Chinese herbal medicines for the treatment of premature ovarian insufficiency: A systematic review and meta-analysis Li Y, Xia G, Tan Y, Shuai J
Systematic Review Ovarian Insufficiency
In a meta-analysis involving 14 trials with 1030 women experiencing Premature Ovarian Insufficiency (POI), acupoint stimulation and Chinese Herbal Medicine (CHM) were found to offer benefits in normalizing menstrual cycles and improving perimenopausal symptoms, compared to Hormone Replacement Therapy (HRT). These treatments also effectively lowered follicle stimulating hormone levels and increased estradiol levels when compared to HRT. However, there were no significant differences in luteinizing hormone levels or adverse effects between the groups. The conclusion of the study is that acupoint stimulation and CHM can be considered complementary therapies for alleviating menstrual disorders, perimenopausal symptoms, and serum sex hormone levels in POI females.
Black pepper, beyond its culinary use, offers medicinal benefits like antimicrobial, antioxidant, anticancer, anti-diabetic, and anti-inflammatory properties mainly attributed to the compound piperine.
2019 Critical Reviews in Food Science and Nutrition A systematic review on black pepper (Piper nigrum L.): from folk uses to pharmacological applications Takooree H, Aumeeruddy MZ, Rengasamy KRR, Venugopala KN, Jeewon R, Zengin G, et al.
Systematic Review Black Pepper
The study was a systematic review of existing scientific data on the traditional uses, composition, and pharmacological attributes of black pepper. Information was gathered from recognized databases such as Science Direct and Google Scholar, as well as books and other online resources. The study primarily focused on literature in English and evaluated traditional medicinal uses of black pepper in various regions, the common ailments it was used to address, and the preferred modes of preparation.
The results of the study affirm the significant medicinal qualities of black pepper. Its antimicrobial activity was demonstrated against various pathogens, and it showed strong antioxidant effects against several reactive oxygen and nitrogen species. The research also highlighted the anticancer effects of black pepper on cell lines from various sites including breast, colon, cervix, and prostate. Furthermore, the benefits of black pepper in managing diabetes and lipid levels in the body were also confirmed. It was also noted for its anti-inflammatory, analgesic, anticonvulsant, and neuroprotective effects. Piperine was identified as the major bioactive compound in black pepper which is responsible for these beneficial effects along with other compounds such as piperic acid, piperlonguminine, and more.
Review Articles
Review articles summarise and critically evaluate the current state of research on a specific topic or field by synthesising multiple primary research studies.
The Treatment with Complementary and Alternative Traditional Chinese Medicine for Menstrual Disorders with Polycystic Ovary Syndrome
2021 May 17 Evidence-Based Complementary and Alternative Medicine Zhang Y, Guo X, Ma S, Ma H, Li H, Wang Y, et al.
For PCOS menstrual disorders, TCM and acupuncture are the most commonly used CAM methods, but other CAM medicine therapies also help improve PCOS menstrual disorders.
Review Article PCOSAcupoint stimulation and Chinese herbal medicines for the treatment of premature ovarian insufficiency: A systematic review and meta-analysis
2020 Nov Complementary Therapies in Medicine Li Y, Xia G, Tan Y, Shuai J
Systematic Review Meta-Analysis Ovarian InsufficiencyIn a meta-analysis of 14 trials with 1030 women, acupoint stimulation and Chinese Herbal Medicine were effective in improving menstrual cycles, perimenopausal symptoms, and sex hormone levels in comparison to Hormone Replacement Therapy.
A systematic review on black pepper (Piper nigrum L.): from folk uses to pharmacological applications
2019 Feb 11 Critical Reviews in Food Science and Nutrition Takooree H, Aumeeruddy MZ, Rengasamy KRR, Venugopala KN, Jeewon R, Zengin G, et al.
Systematic Review Black PepperBlack pepper, beyond its culinary use, offers medicinal benefits like antimicrobial, antioxidant, anticancer, anti-diabetic, and anti-inflammatory properties mainly attributed to the compound piperine.
Pharmacological effects of Radix Angelica Sinensis (Danggui) on cerebral infarction
2011 Jan Chinese Medicine Wu YC, Hsieh CL
The effects of Danggui on cerebral infarction are through multiple pathways, including anti-arthrosclerosis, improving microcirculation, anti-platelet aggregation, anti-inflammatory and anti-oxidative effects (Table 1). Danggui may be useful in treating the cerebral infarction type of stroke.
Review Article StrokeClinical Trials
Clinical trials are research studies that involve people and are conducted to evaluate the safety and efficacy of new treatments or interventions, such as drugs, medical devices, or behavioural therapies.
Presentation Slides
Si Wu Tang has improved menstrual symptoms by increasing estradiol content and antioxidative effects as a result of its herbs' synergistic relationships.
In a meta-analysis of 14 trials with 1030 women, acupoint stimulation and Chinese Herbal Medicine were effective in improving menstrual cycles, perimenopausal symptoms, and sex hormone levels in comparison to Hormone Replacement Therapy.
Black pepper, beyond its culinary use, offers medicinal benefits like antimicrobial, antioxidant, anticancer, anti-diabetic, and anti-inflammatory properties mainly attributed to the compound piperine.
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