Pneumonia
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Research Articles
Published research studies are articles that present the findings of original research that has undergone a peer-review process and has been made publicly available in scholarly journals, books or other media.
Advances in the chemical constituents, pharmacological properties and clinical applications of TCM formula Yupingfeng San
2023 Jan Fitoterapia Bai Y, Wei W, Yao C, Wu S, Wang W, Guo D
The potential bioactive constituents of this formula could be classified as polysaccharides, flavonoids, and saponins. The findings indicated that YPFS is a safe and effective therapeutic Chinese formula against various diseases, including immunological diseases, inflammations, tumors and pulmonary diseases, but only a few relevant randomized, double-blind, placebo-control, and multi-center clinical trials were reported.
Review Article
Traditional Chinese medicines as effective agents against influenza virus-induced pneumonia
2022 Sep Biomedicine & Pharmacotherapy Yang M, Wang Y, Yue Y, Liang L, Peng M, Zhao M, et al.
There has been some progress in the prevention and treatment of IVP by using TCMs. However, most research has focused on viral replication, the role of inflammatory cytokines, oxidative stress, and lung inflammatory cell infiltration in the pathogenesis of the disease, while there has been relatively little in-depth research on the lung lesions caused by influenza virus infection and on the role TCMs may have in preventing them. At present, analyses of the chemical components and mechanisms of action of TCMs useful in the treatment of IVP are insufficient, and this restricts their further use.
Systematic Review Meta-Analysis Pneumonia influenza virus-induced pneumonia
Jing Si Herbal Drink as a prospective adjunctive therapy for COVID-19 treatment: Molecular evidence and mechanisms
2022 Mar Pharmacological Research - Modern Chinese Medicine Lu PH, Tseng CW, Lee JL, Lee EY, Lin YP, Lin IH, et al.
Review Article Randomised Controlled Trial Gan Cao Ai Ye Antiviral COVID-19 Jing Si Herbal Drink Immunity Antioxidant Yu Jen Cao Yu Xing Cao Anti-Inflammatory Mai Dong Chrysanthemum Jie GengThe Jing Si Herbal Drink, composed of various antiviral, antioxidant and anti-inflammatory herbs, has been confirmed as potentially effective in treating COVID-19 symptoms.
Analysis of knowledge graph based on CiteSpace research on the treatment of pediatric pneumonia with traditional Chinese medicine
2022 Jan Infectious Diseases Research Fang XX, Dong JX, Wu ZQ, Yang HC, Cui HT, Liu YL
At present, the research on the treatment of children's pneumonia with traditional Chinese medicine shows an increasing trend.
Children's Health
Clinical Efficacy and Safety of Shashen Maidong Decoction in the Treatment of Pediatric Mycoplasma Pneumonia: A Systematic Review and Meta-Analysis
2021 Oct 12 Frontiers in Pharmacology Wang J, Ma X, Wei S, Yang T, Tong Y, Jing M, et al.
Shashen Maidong Decoction has a significant improvement in the levels of relevant indexes in pediatric mycoplasma pneumonia, which provides a basis for the safety and efficacy of pediatric mycoplasma pneumonia. However, due to the small sample size included in the study, the study quality was not high, and more randomized controlled trials of high quality are required for further validation.
Systematic Review Meta-Analysis Mycoplasma Pneumonia Sha Shen Mai Dong Decoction Sha Shen PneumoniaResearch Insights
Insights are moderated by the Research Hub team and offer an at-a-glance overview of interesting research findings.
The Jing Si Herbal Drink, composed of various antiviral, antioxidant and anti-inflammatory herbs, has been confirmed as potentially effective in treating COVID-19 symptoms.
2022 Pharmacological Research - Modern Chinese Medicine Jing Si Herbal Drink as a prospective adjunctive therapy for COVID-19 treatment: Molecular evidence and mechanisms Lu PH, Tseng CW, Lee JL, Lee EY, Lin YP, Lin IH, et al.
Review Article Ai Ye Anti-Inflammatory Antioxidant
The methodology incorporated in this study involves analyzing the efficacy of the component herbs present in Jing Si Herbal Drink (JSHD). This was done through in vivo and in vitro testing to understand their potential in treating COVID-19. JSHD comprises a combination of 5 antiviral, 7 antioxidant, 7 anti-inflammatory herbs. Furthermore, it includes 2 herbs that inhibit the overactive immune system, one herb that reduces cell apoptosis, and another with antithrombotic ability. These constituent herbs were evaluated for their impact on the pathogenesis of COVID-19.
Discussion of the results showed that the ingredients in JSHD have demonstrated potential effectiveness against COVID-19. The active ingredients in the drink were effective in providing symptomatic relief for infected patients. The antiviral, antioxidant, and anti-inflammatory herbs, along with those altering immune response, inhibiting cellular apoptosis and providing antithrombotic capacity, were all found beneficial against the disease. Thus, JSHD holds promise as a useful adjuvant or supplementary treatment in handling COVID-19.
Yu Xing Cao, a traditional Asian medicine, demonstrates organ protection, immune regulation, and anti-tumour activity when analysed in modern research.
2021 Frontiers in Pharmacology Houttuynia cordata Thunb: An Ethnopharmacological Review Wu Z, Deng X, Hu Q, Xiao X, Jiang J, Ma X, et al.
Review Article
The methodology used in this review began by harnessing key search terms such as 'H. cordata and lung', 'H. cordata and heart', 'H. cordata and liver', and 'H. cordata and inflammation' to query research databases including PubMed, Web of Science and ScienceDirect. The focus was on articles published within the past decade that aligned significantly with the chosen keywords. Contents, disease models and research methods from these articles were analysed to form a comprehensive understanding of H. cordata's therapeutic effects.
Results from the review found that H. cordata contained a variety of chemical constituents common to medicinal plants, including flavonoids and volatile oils, identified as the main active components. The plant demonstrated a range of pharmacological activities including organ protection, where it reduced the release of inflammatory factors to alleviate lung injury. The immunity regulation aspect enhanced immune barriers in the vagina, oral cavity, and intestinal tract, reducing pathogen infection due to its combined antibacterial and antiviral activity. It was also observed to have anti-inflammatory and anti-tumour properties, with a noted effect on lung, liver, colon, and breast tumours.
Traditional Chinese medicine has unique advantages in relieving symptoms, shortening treatment time and reducing the development of severe viral pneumonia.
2020 Frontiers in Pharmacology Role of Traditional Chinese Medicine in the Management of Viral Pneumonia Xi S, Li Y, Yue L, Gong Y, Qian L, Liang T, et al.
Review Article Common Cold Common Cold, Flu & Viral Infections
In the treatment of viral pneumonia through syndrome differentiation, traditional Chinese medicine (TCM) plays a variety of roles in inhibiting the proliferation, replication, adsorption and membrane penetration of the virus, promoting the expression of interferon in vivo, inhibiting inflammatory reaction, enhancing immunity, etc., which is one of the theoretical bases for the clinical application of TCM in the prevention and treatment of viral pneumonia.
Traditional Chinese herbal medicine and compound medicinals are characterized by multi-component, multi-pathway and multi-pathway complex networks. Therefore, drug resistance is relatively rare in the clinical practice of TCM. Moreover, in the process of diagnosis and treatment of TCM, treatment based on differentiation of symptoms and signs, especially treatment based on classification of symptoms and signs, can best reflect the overall concept of TCM. TCM has precise therapeutic activity and less adverse reactions. Accumulating evidence has demonstrated the competent therapeutic effects of TCM against viral pneumonia with a prominent safety profile.
Chinese medicine combined with conventional treatment significantly improved clinical efficacy, increased viral nucleic acid negative conversion rate, prominently reduced pulmonary inflammation, and improved host immune function.
2020 The American Journal of Emergency Medicine The role of Chinese medicine in COVID-19 pneumonia: A systematic review and meta-analysis Sun, C. Y., Sun, Y. L., & Li, X. M.
Systematic Review COVID-19
A total of 7 valid studies involving 681 patients were included. The meta-analysis exhibited in comparison to conventional treatment, Chinese medicine combined with conventional treatment significantly improved clinical efficacy, and significantly increased viral nucleic acid negative conversion rate. Chinese medicine also prominently reduced pulmonary inflammation, and improved host immune function. Meanwhile, Chinese medicine did not increase the incidence of adverse reactions.
According to the allocated data, Chinese medicine has demonstrated clinical efficacy and safety on COVID-19 pneumonia, which need to be confirmed by high quality, multiple-center, large sample randomized controlled trials.
Review Articles
Review articles summarise and critically evaluate the current state of research on a specific topic or field by synthesising multiple primary research studies.
Advances in the chemical constituents, pharmacological properties and clinical applications of TCM formula Yupingfeng San
2023 Jan Fitoterapia Bai Y, Wei W, Yao C, Wu S, Wang W, Guo D
The potential bioactive constituents of this formula could be classified as polysaccharides, flavonoids, and saponins. The findings indicated that YPFS is a safe and effective therapeutic Chinese formula against various diseases, including immunological diseases, inflammations, tumors and pulmonary diseases, but only a few relevant randomized, double-blind, placebo-control, and multi-center clinical trials were reported.
Review ArticleTraditional Chinese medicines as effective agents against influenza virus-induced pneumonia
2022 Sep Biomedicine & Pharmacotherapy Yang M, Wang Y, Yue Y, Liang L, Peng M, Zhao M, et al.
There has been some progress in the prevention and treatment of IVP by using TCMs. However, most research has focused on viral replication, the role of inflammatory cytokines, oxidative stress, and lung inflammatory cell infiltration in the pathogenesis of the disease, while there has been relatively little in-depth research on the lung lesions caused by influenza virus infection and on the role TCMs may have in preventing them. At present, analyses of the chemical components and mechanisms of action of TCMs useful in the treatment of IVP are insufficient, and this restricts their further use.
Systematic Review Meta-Analysis Pneumonia influenza virus-induced pneumoniaJing Si Herbal Drink as a prospective adjunctive therapy for COVID-19 treatment: Molecular evidence and mechanisms
2022 Mar Pharmacological Research - Modern Chinese Medicine Lu PH, Tseng CW, Lee JL, Lee EY, Lin YP, Lin IH, et al.
Review Article Randomised Controlled Trial Gan Cao Ai Ye Antiviral COVID-19 Jing Si Herbal Drink Immunity Antioxidant Yu Jen Cao Yu Xing Cao Anti-Inflammatory Mai Dong Chrysanthemum Jie GengThe Jing Si Herbal Drink, composed of various antiviral, antioxidant and anti-inflammatory herbs, has been confirmed as potentially effective in treating COVID-19 symptoms.
Clinical Efficacy and Safety of Shashen Maidong Decoction in the Treatment of Pediatric Mycoplasma Pneumonia: A Systematic Review and Meta-Analysis
2021 Oct 12 Frontiers in Pharmacology Wang J, Ma X, Wei S, Yang T, Tong Y, Jing M, et al.
Shashen Maidong Decoction has a significant improvement in the levels of relevant indexes in pediatric mycoplasma pneumonia, which provides a basis for the safety and efficacy of pediatric mycoplasma pneumonia. However, due to the small sample size included in the study, the study quality was not high, and more randomized controlled trials of high quality are required for further validation.
Systematic Review Meta-Analysis Mycoplasma Pneumonia Sha Shen Mai Dong Decoction Sha Shen PneumoniaHouttuynia cordata Thunb: An Ethnopharmacological Review
2021 Sep 01 Frontiers in Pharmacology Wu Z, Deng X, Hu Q, Xiao X, Jiang J, Ma X, et al.
Review ArticleYu Xing Cao, a traditional Asian medicine, demonstrates organ protection, immune regulation, and anti-tumour activity when analysed in modern research.
Clinical Trials
Clinical trials are research studies that involve people and are conducted to evaluate the safety and efficacy of new treatments or interventions, such as drugs, medical devices, or behavioural therapies.
Study Protocols
Published study protocols are detailed plans that outline the objectives, methodology, statistical analyses, and organisation of a research study that have been made publicly available for others to review and use as a reference.
Presentation Slides
The Jing Si Herbal Drink, composed of various antiviral, antioxidant and anti-inflammatory herbs, has been confirmed as potentially effective in treating COVID-19 symptoms.
Yu Xing Cao, a traditional Asian medicine, demonstrates organ protection, immune regulation, and anti-tumour activity when analysed in modern research.
Traditional Chinese medicine has unique advantages in relieving symptoms, shortening treatment time and reducing the development of severe viral pneumonia.
Chinese medicine combined with conventional treatment significantly improved clinical efficacy, increased viral nucleic acid negative conversion rate, prominently reduced pulmonary inflammation, and improved host immune function.
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