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Research Articles
Published research studies are articles that present the findings of original research that has undergone a peer-review process and has been made publicly available in scholarly journals, books or other media.
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The whole pomegranate (Punica granatum. L), biological properties and important findings: A review
2023 Oct Food Chemistry Advances Valero-Mendoza AG, Meléndez-Rentería NP, Chávez-González ML, Flores-Gallegos AC, Wong-Paz JE, Govea-Salas M, et al.
Review Article Antiviral Antimicrobial Pomegranate AnticancerPomegranate and its by-products, particularly the peel, contain bioactive compounds with potential antimicrobial, anticancer and antiviral properties.
“An integrative approach with Ayurveda and Traditional Chinese Acupuncture in post covid parosmia – A case study”
2023 Jan Journal of Ayurveda and Integrative Medicine Bhat AK, Krishna Kumar V, Johnson JD
Parosmia was assessed by VAS which was ten on day one and zero on day seven. We could achieve complete normalcy in olfactory function within four months of this treatment. This integrative approach was found to be safe and effective in treating Post covid parosmia.
Case Report COVID-19 Acupuncture AyurvedaClinical data mining reveals Gancao-Banxia as a potential herbal pair against moderate COVID‐19 by dual binding to IL-6/STAT3
2022 Jun Computers in Biology and Medicine Luo W, Ding R, Guo X, Zhan T, Tang T, Fan R, et al.
This work provided some potential candidate Chinese medicine formulas for moderate COVID-19. Among them, Gancao-Banxia was considered the most potential herbal pair with strong bioinformatics suggesting resistance against COVID. SARS-CoV-2 models will be needed to validate this possibility in the future.
Meta-Analysis COVID-19 Gan CaoJing Si Herbal Drink as a prospective adjunctive therapy for COVID-19 treatment: Molecular evidence and mechanisms
2022 Mar Pharmacological Research - Modern Chinese Medicine Lu PH, Tseng CW, Lee JL, Lee EY, Lin YP, Lin IH, et al.
Review Article Randomised Controlled Trial Gan Cao Ai Ye Antiviral COVID-19 Jing Si Herbal Drink Immunity Antioxidant Yu Jen Cao Yu Xing Cao Anti-Inflammatory Mai Dong Chrysanthemum Jie GengThe Jing Si Herbal Drink, composed of various antiviral, antioxidant and anti-inflammatory herbs, has been confirmed as potentially effective in treating COVID-19 symptoms.
Possible Beneficial Effects of Fresh Pomegranate Juice in SARS-CoV-2 Infection Conditions
2022 Mar 05 Journal of Nutrition and Metabolism Banihani SA
Review Article Pomegranate COVID-19Pomegranate juice, due to its unique bioactive compounds, could potentially alleviate complications related to SARS-CoV-2 infections, especially in patients with pre-existing chronic diseases.
Research Insights
Insights are moderated by the Research Hub team and offer an at-a-glance overview of interesting research findings.
FCA
Pomegranate and its by-products, particularly the peel, contain bioactive compounds with potential antimicrobial, anticancer and antiviral properties.
2023 Food Chemistry Advances The whole pomegranate (Punica granatum. L), biological properties and important findings: A review Valero-Mendoza AG, Meléndez-Rentería NP, Chávez-González ML, Flores-Gallegos AC, Wong-Paz JE, Govea-Salas M, et al.
Review Article Anticancer Antimicrobial Antiviral
In the methodological approach of the study, a comprehensive review was undertaken to collate information on the bioactive components found within pomegranates and their by-products (aril, seed, and peel). The study emphasized the pomegranate peel's properties owing to its high content of the bioactive compounds. The aim was to elucidate the nutritional and functional aspects of pomegranates, particularly as a functional food.
The results outlined that pomegranates, especially their peel, contain bioactive compounds, including punicalagin, punicalin, ellagic acid, punicic acid, and anthocyanins. Therefore, they have potential functional properties such as antimicrobial, anticancer, and antiviral characteristics. These results suggest that pomegranates could be explored to develop nutraceutical or functional food products due to their profound properties. The peel of the pomegranate, specifically, showcases significant potential for development due to its higher bioactive compound content compared to other parts of the fruit.
Pomegranate juice, due to its unique bioactive compounds, could potentially alleviate complications related to SARS-CoV-2 infections, especially in patients with pre-existing chronic diseases.
2022 Journal of Nutrition and Metabolism Possible Beneficial Effects of Fresh Pomegranate Juice in SARS-CoV-2 Infection Conditions Banihani SA
Review Article COVID-19 Pomegranate
The methodology employed in this research involved reviewing and discussing currently available published evidence of the beneficial effects of pomegranate juice during conditions of viral infections. The team exploited databases such as PubMed and Scopus to access relevant references. They centered their investigation around the hypothesis that the bioactive compounds in fresh pomegranate juice are advantageous in various chronic diseased conditions, thereby making the juice potentially beneficial for SARS-CoV-2 infected patients.
In the discussion of results, the researchers found compelling evidence supporting the idea that pomegranate juice can be helpful in the contexts of SARS-CoV-2 infections, particularly for those patients who have a clinical history of chronic diseases like hypertension, cardiovascular disease, diabetes, and cancer. Notably, they point out that it is the unique bioactive compounds in the juice that make it beneficial for such situations.
The Jing Si Herbal Drink, composed of various antiviral, antioxidant and anti-inflammatory herbs, has been confirmed as potentially effective in treating COVID-19 symptoms.
2022 Pharmacological Research - Modern Chinese Medicine Jing Si Herbal Drink as a prospective adjunctive therapy for COVID-19 treatment: Molecular evidence and mechanisms Lu PH, Tseng CW, Lee JL, Lee EY, Lin YP, Lin IH, et al.
Review Article Ai Ye Anti-Inflammatory Antioxidant
The methodology incorporated in this study involves analyzing the efficacy of the component herbs present in Jing Si Herbal Drink (JSHD). This was done through in vivo and in vitro testing to understand their potential in treating COVID-19. JSHD comprises a combination of 5 antiviral, 7 antioxidant, 7 anti-inflammatory herbs. Furthermore, it includes 2 herbs that inhibit the overactive immune system, one herb that reduces cell apoptosis, and another with antithrombotic ability. These constituent herbs were evaluated for their impact on the pathogenesis of COVID-19.
Discussion of the results showed that the ingredients in JSHD have demonstrated potential effectiveness against COVID-19. The active ingredients in the drink were effective in providing symptomatic relief for infected patients. The antiviral, antioxidant, and anti-inflammatory herbs, along with those altering immune response, inhibiting cellular apoptosis and providing antithrombotic capacity, were all found beneficial against the disease. Thus, JSHD holds promise as a useful adjuvant or supplementary treatment in handling COVID-19.
Traditional Chinese medicine could reduce the all-cause mortality in COVID-19 patients, inhibit virus replication and transcription, and attenuate the cytokine storm and immune deficiency caused by the SARS-CoV-2.
2021 Biomedicine & Pharmacotherapy The direct evidence and mechanism of traditional Chinese medicine treatment of COVID-19 Xuedong An, YueHong Zhang, Liyun Duan, De Jin, Shenghui Zhao, RongRong Zhou, et al.
COVID-19
Presently, there is good evidence that TCM can effectively alleviate the symptoms of patients with suspected and confirmed COVID-19, delay the progression from mild and moderate to severe and critical disease, and reduce severe and critical all-cause mortality. The role of TCM is related to affecting the transcription, replication, and binding of SARS-CoV-2 to the host and attenuating the cytokine storm and weak immunity in patients with COVID-19.
Bee honey and propolis could have potential beneficial effects as supporting treatments for COVID-19, enhancing immunity and inhibiting viral activity.
2021 Molecules Propolis, Bee Honey, and Their Components Protect against Coronavirus Disease 2019 (COVID-19): A Review of In Silico, In Vitro, and Clinical Studies Ali AM, Kunugi H
Review Article Anti-Inflammatory Antiviral COVID-19
The study's methodology involved a comprehensive review of the literature on the potential anti-COVID-19 effects of bee honey and propolis, products known for their strong antimicrobial and antioxidant abilities. The researchers conducted molecular simulations to see how various flavonoids found in these products might inhibit essential viral processes. Additionally, they compared the effectiveness of propolis extracts delivered by nanocarriers to ethanolic extracts, and they examined the effects of a combination of honey and propolis on hospitalized COVID-19 patients.
The findings from the review and simulations suggested that certain flavonoids in honey and propolis may inhibit the fusion of the virus spike with host cells, interactions that cause a cytokine storm, and viral replication. Propolis ethanolic extract, rutin, and propolis liposomes displayed inhibitory action against non-structural proteins of the virus in vitro while naringin inhibited viral infection in specific cells. When delivered via nanocarriers, propolis extracts showed enhanced antiviral effects against the virus compared to ethanolic extracts. Observations of hospitalized patients suggested that those treated with green Brazilian propolis or a honey-propolis combination experienced quicker viral clearance, symptom recovery, and hospital discharge, along with lower mortality rates.
Review Articles
Review articles summarise and critically evaluate the current state of research on a specific topic or field by synthesising multiple primary research studies.
The whole pomegranate (Punica granatum. L), biological properties and important findings: A review
2023 Oct Food Chemistry Advances Valero-Mendoza AG, Meléndez-Rentería NP, Chávez-González ML, Flores-Gallegos AC, Wong-Paz JE, Govea-Salas M, et al.
Review Article Antiviral Antimicrobial Pomegranate AnticancerPomegranate and its by-products, particularly the peel, contain bioactive compounds with potential antimicrobial, anticancer and antiviral properties.
Jing Si Herbal Drink as a prospective adjunctive therapy for COVID-19 treatment: Molecular evidence and mechanisms
2022 Mar Pharmacological Research - Modern Chinese Medicine Lu PH, Tseng CW, Lee JL, Lee EY, Lin YP, Lin IH, et al.
Review Article Randomised Controlled Trial Gan Cao Ai Ye Antiviral COVID-19 Jing Si Herbal Drink Immunity Antioxidant Yu Jen Cao Yu Xing Cao Anti-Inflammatory Mai Dong Chrysanthemum Jie GengThe Jing Si Herbal Drink, composed of various antiviral, antioxidant and anti-inflammatory herbs, has been confirmed as potentially effective in treating COVID-19 symptoms.
Possible Beneficial Effects of Fresh Pomegranate Juice in SARS-CoV-2 Infection Conditions
2022 Mar 05 Journal of Nutrition and Metabolism Banihani SA
Review Article Pomegranate COVID-19Pomegranate juice, due to its unique bioactive compounds, could potentially alleviate complications related to SARS-CoV-2 infections, especially in patients with pre-existing chronic diseases.
Role of vitamin D supplementation in aging patients with COVID-19
2021 Oct Maturitas Shakoor H, Feehan J, Al Dhaheri AS, Cheikh Ismail L, Ali HI, Alhebshi SH, et al.
Review Article COVID-19Propolis, Bee Honey, and Their Components Protect against Coronavirus Disease 2019 (COVID-19): A Review of In Silico, In Vitro, and Clinical Studies
2021 Feb 25 Molecules Ali AM, Kunugi H
Review Article Antiviral Immunomodulation Anti-Inflammatory COVID-19 HoneyBee honey and propolis could have potential beneficial effects as supporting treatments for COVID-19, enhancing immunity and inhibiting viral activity.
Clinical Trials
Clinical trials are research studies that involve people and are conducted to evaluate the safety and efficacy of new treatments or interventions, such as drugs, medical devices, or behavioural therapies.
Study Protocols
Published study protocols are detailed plans that outline the objectives, methodology, statistical analyses, and organisation of a research study that have been made publicly available for others to review and use as a reference.
Presentation Slides
Review Article
Pomegranate and its by-products, particularly the peel, contain bioactive compounds with potential antimicrobial, anticancer and antiviral properties.
Valero-Mendoza AG, Meléndez-Rentería NP, Chávez-González ML, Flores-Gallegos AC, Wong-Paz JE, Govea-Salas M, Zugasti-Cruz A, Ascacio-Valdés JA
Review Article
Pomegranate juice, due to its unique bioactive compounds, could potentially alleviate complications related to SARS-CoV-2 infections, especially in patients with pre-existing chronic diseases.
Banihani SA
Review Article
The Jing Si Herbal Drink, composed of various antiviral, antioxidant and anti-inflammatory herbs, has been confirmed as potentially effective in treating COVID-19 symptoms.
Lu PH, Tseng CW, Lee JL, Lee EY, Lin YP, Lin IH, Yu MC, Lu KC, Kuo KL
Traditional Chinese medicine could reduce the all-cause mortality in COVID-19 patients, inhibit virus replication and transcription, and attenuate the cytokine storm and immune deficiency caused by the SARS-CoV-2.
Xuedong An, YueHong Zhang, Liyun Duan, De Jin, Shenghui Zhao, RongRong Zhou, Yingying Duan, Fengmei Lian, Xiaolin Tong
Review Article
Bee honey and propolis could have potential beneficial effects as supporting treatments for COVID-19, enhancing immunity and inhibiting viral activity.
Ali AM, Kunugi H
Executive Summary
Write an executive summary in the form of a blog article on the topic of "Research into Chinese medicine treatment for SARS" summarising the research below and using language that can be easily understood by patients and avoiding medical jargon using a professional and caring tone of voice.
Write an executive summary in the form of a blog article on the topic of "Researched Chinese medicine treatments for SARS" summarising the research below in an objective and easy to understand way, and using language that can be easily understood by patients. Group the article into Chinese medicine treatments first, followed by nutrition and other treatments. Avoid using medical jargon and use a professional and caring tone of voice.
Write me a concise but easy to understand executive summary on the topic of "Chinese medicine treatments for SARS" based on the following research that I will give you. Your summary should be 2 paragraphs long in Australian English spelling and include references to the studies.
A Review Article published in 2023 in the journal Food Chemistry Advances found that Pomegranate and its by-products, particularly the peel, contain bioactive compounds with potential antimicrobial, anticancer and antiviral properties. In the methodological approach of the study, a comprehensive review was undertaken to collate information on the bioactive components found within pomegranates and their by-products (aril, seed, and peel). The study emphasized the pomegranate peel's properties owing to its high content of the bioactive compounds. The aim was to elucidate the nutritional and functional aspects of pomegranates, particularly as a functional food. The results outlined that pomegranates, especially their peel, contain bioactive compounds, including punicalagin, punicalin, ellagic acid, punicic acid, and anthocyanins. Therefore, they have potential functional properties such as antimicrobial, anticancer, and antiviral characteristics. These results suggest that pomegranates could be explored to develop nutraceutical or functional food products due to their profound properties. The peel of the pomegranate, specifically, showcases significant potential for development due to its higher bioactive compound content compared to other parts of the fruit.
A Review Article published in 2022 in the journal Journal of Nutrition and Metabolism found that Pomegranate juice, due to its unique bioactive compounds, could potentially alleviate complications related to SARS-CoV-2 infections, especially in patients with pre-existing chronic diseases. The methodology employed in this research involved reviewing and discussing currently available published evidence of the beneficial effects of pomegranate juice during conditions of viral infections. The team exploited databases such as PubMed and Scopus to access relevant references. They centered their investigation around the hypothesis that the bioactive compounds in fresh pomegranate juice are advantageous in various chronic diseased conditions, thereby making the juice potentially beneficial for SARS-CoV-2 infected patients. In the discussion of results, the researchers found compelling evidence supporting the idea that pomegranate juice can be helpful in the contexts of SARS-CoV-2 infections, particularly for those patients who have a clinical history of chronic diseases like hypertension, cardiovascular disease, diabetes, and cancer. Notably, they point out that it is the unique bioactive compounds in the juice that make it beneficial for such situations.
A Review Article published in 2022 in the journal Pharmacological Research - Modern Chinese Medicine found that The Jing Si Herbal Drink, composed of various antiviral, antioxidant and anti-inflammatory herbs, has been confirmed as potentially effective in treating COVID-19 symptoms. The methodology incorporated in this study involves analyzing the efficacy of the component herbs present in Jing Si Herbal Drink (JSHD). This was done through in vivo and in vitro testing to understand their potential in treating COVID-19. JSHD comprises a combination of 5 antiviral, 7 antioxidant, 7 anti-inflammatory herbs. Furthermore, it includes 2 herbs that inhibit the overactive immune system, one herb that reduces cell apoptosis, and another with antithrombotic ability. These constituent herbs were evaluated for their impact on the pathogenesis of COVID-19. Discussion of the results showed that the ingredients in JSHD have demonstrated potential effectiveness against COVID-19. The active ingredients in the drink were effective in providing symptomatic relief for infected patients. The antiviral, antioxidant, and anti-inflammatory herbs, along with those altering immune response, inhibiting cellular apoptosis and providing antithrombotic capacity, were all found beneficial against the disease. Thus, JSHD holds promise as a useful adjuvant or supplementary treatment in handling COVID-19.
A published in 2021 in the journal Biomedicine & Pharmacotherapy found that Traditional Chinese medicine could reduce the all-cause mortality in COVID-19 patients, inhibit virus replication and transcription, and attenuate the cytokine storm and immune deficiency caused by the SARS-CoV-2. Presently, there is good evidence that TCM can effectively alleviate the symptoms of patients with suspected and confirmed COVID-19, delay the progression from mild and moderate to severe and critical disease, and reduce severe and critical all-cause mortality. The role of TCM is related to affecting the transcription, replication, and binding of SARS-CoV-2 to the host and attenuating the cytokine storm and weak immunity in patients with COVID-19.
A Review Article published in 2021 in the journal Molecules found that Bee honey and propolis could have potential beneficial effects as supporting treatments for COVID-19, enhancing immunity and inhibiting viral activity. The study's methodology involved a comprehensive review of the literature on the potential anti-COVID-19 effects of bee honey and propolis, products known for their strong antimicrobial and antioxidant abilities. The researchers conducted molecular simulations to see how various flavonoids found in these products might inhibit essential viral processes. Additionally, they compared the effectiveness of propolis extracts delivered by nanocarriers to ethanolic extracts, and they examined the effects of a combination of honey and propolis on hospitalized COVID-19 patients. The findings from the review and simulations suggested that certain flavonoids in honey and propolis may inhibit the fusion of the virus spike with host cells, interactions that cause a cytokine storm, and viral replication. Propolis ethanolic extract, rutin, and propolis liposomes displayed inhibitory action against non-structural proteins of the virus in vitro while naringin inhibited viral infection in specific cells. When delivered via nanocarriers, propolis extracts showed enhanced antiviral effects against the virus compared to ethanolic extracts. Observations of hospitalized patients suggested that those treated with green Brazilian propolis or a honey-propolis combination experienced quicker viral clearance, symptom recovery, and hospital discharge, along with lower mortality rates.
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No too sure what article type this is, however I put review —Adrian Y 13 Jul 2023