Skeletal Muscle
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Iron deficiency promotes a shift towards a more glycolytic metabolism, without detectable effect on mitochondrial bioenergetics, which can be corrected with iron supplements.
Iron Deficiency Skeletal Muscle
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Research Articles
Published research studies are articles that present the findings of original research that has undergone a peer-review process and has been made publicly available in scholarly journals, books or other media.
Skeletal muscles and gut microbiota-derived metabolites: novel modulators of adipocyte thermogenesis
2023 Oct 06 Frontiers in Endocrinology Tang Y, Wang YD, Wang YY, Liao ZZ, Xiao XH
The study concludes that metabolites from skeletal muscles and gut microbiota function as signaling molecules, interacting with membrane receptors or controlling intracellular enzyme activity, and have the potential to regulate adipocyte thermogenesis in obesity.
Review Article Skeletal Muscle Gut Microbiota
Anti-Obesity Effects and the Regulation of Energy Metabolism in Skeletal Muscle Tissues of Allii Fistulosi Bulbus Extract in High Fat Diet-Induced Obesity Mice
2022 Dec 31 Journal of Korean Medicine for Obesity Research Choi YY, Lee HS, Baik SY, Lim S, Jung HW, Kang SY, et al.
In summary, GHH treatment promoted glucose uptake in C2C12 myotubes. We suggest that these effects are associated with increased gene expression involved in mitochondrial biosynthesis and oxidative phosphorylation, such as Tfam and Ppargc1a, and increased expression of AMPK protein.
Animal Study ObesityAbnormal whole-body energy metabolism in iron-deficient humans despite preserved skeletal muscle oxidative phosphorylation
2022 Jan 19 Scientific Reports Frise MC, Holdsworth DA, Johnson AW, Chung YJ, Curtis MK, Cox PJ, et al.
Experimental Study Clinical Study Skeletal Muscle Iron DeficiencyIron deficiency promotes a shift towards a more glycolytic metabolism, without detectable effect on mitochondrial bioenergetics, which can be corrected with iron supplements.
Impacts of Green Tea on Joint and Skeletal Muscle Health: Prospects of Translational Nutrition
2020 Oct 28 Antioxidants Luk HY, Appell C, Chyu MC, Chen CH, Wang CY, Yang RS, et al.
Review Article Green Tea Sarcopenia Green Tea Catechin ArthritisGreen tea catechins potentially contribute to maintaining joint and skeletal muscle health, mitigating symptoms of osteoarthritis and sarcopenia.
Apitherapy for Age-Related Skeletal Muscle Dysfunction (Sarcopenia): A Review on the Effects of Royal Jelly, Propolis, and Bee Pollen
2020 Sep 25 Foods Ali AM, Kunugi H
Bee products, rich in antioxidants and with versatile pharmacological activities, have shown varying positive effects on muscle mass, strength, and function in laboratory animals and limited human studies. Potential mechanisms include reducing inflammation and oxidative damage, promoting metabolic regulation, enhancing satellite stem cell responsiveness, improving muscular blood supply, inhibiting catabolic genes, and promoting peripheral neuronal regeneration.
Review Article Bee Pollen SarcopeniaResearch Insights
Insights are moderated by the Research Hub team and offer an at-a-glance overview of interesting research findings.
Iron deficiency promotes a shift towards a more glycolytic metabolism, without detectable effect on mitochondrial bioenergetics, which can be corrected with iron supplements.
2022 Scientific Reports Abnormal whole-body energy metabolism in iron-deficient humans despite preserved skeletal muscle oxidative phosphorylation Frise MC, Holdsworth DA, Johnson AW, Chung YJ, Curtis MK, Cox PJ, et al.
Experimental Study Iron Deficiency
The methodology of this prospective, case-control, clinical physiology study involved two series of testing. Thirteen iron-deficient individuals and thirteen iron-replete control participants were chosen for the study, and they underwent P-magnetic resonance spectroscopy of their exercising calf muscles to investigate the differences in oxidative phosphorylation. This testing was followed by a whole-body cardiopulmonary exercise test. After these assessments, individuals were given an intravenous infusion, which was randomised to be either iron or saline.
The results showed no significant influence of either baseline iron levels or the intravenous iron infusion on the high-energy phosphate metabolism. In the case of submaximal cardiopulmonary exercise, the rate of decline in blood lactate concentration was slower for the iron deficient group, which shows signs of abnormal energy metabolism on a whole-body level. Remarkably, this anomaly was corrected after an intravenous iron infusion. Furthermore, the intravenous iron also increased the lactate threshold during maximal cardiopulmonary exercise by around 10%, no matter what the baseline iron status of the individual was.
Green tea catechins potentially contribute to maintaining joint and skeletal muscle health, mitigating symptoms of osteoarthritis and sarcopenia.
2020 Antioxidants Impacts of Green Tea on Joint and Skeletal Muscle Health: Prospects of Translational Nutrition Luk HY, Appell C, Chyu MC, Chen CH, Wang CY, Yang RS, et al.
Review Article Arthritis Green Tea Green Tea Catechin
The research begins by providing an understanding of osteoarthritis, a degenerative inflammatory disorder of articular cartilage, and sarcopenia, a condition characterized by loss of muscle mass and strength. It explores their prevalence, causes such as excessive inflammation and oxidative stress, mitochondrial dysfunction, and diminished autophagy. It then delves into the role of green tea catechins in joint health, including their influence on inflammatory signaling agents, anabolic mediators, and miRNAs expression.
This leads to a decrease in chondrocyte death and collagen degradation, thereby offering cartilage protection. The investigation also examines the effects of green tea catechins on skeletal muscle health. It highlights their role in maintaining an equilibrium between protein synthesis and degradation, and enhancing the synthesis of mitochondrial energy metabolism.
The review thus suggests a positive impact of green tea catechins on joint and muscle health, helping to maintain favorable muscle homeostasis and reduce muscle atrophy associated with aging. It ends by pointing out the limitations of the current study and proposing future research directions.
Review Articles
Review articles summarise and critically evaluate the current state of research on a specific topic or field by synthesising multiple primary research studies.
Skeletal muscles and gut microbiota-derived metabolites: novel modulators of adipocyte thermogenesis
2023 Oct 06 Frontiers in Endocrinology Tang Y, Wang YD, Wang YY, Liao ZZ, Xiao XH
The study concludes that metabolites from skeletal muscles and gut microbiota function as signaling molecules, interacting with membrane receptors or controlling intracellular enzyme activity, and have the potential to regulate adipocyte thermogenesis in obesity.
Review Article Skeletal Muscle Gut MicrobiotaImpacts of Green Tea on Joint and Skeletal Muscle Health: Prospects of Translational Nutrition
2020 Oct 28 Antioxidants Luk HY, Appell C, Chyu MC, Chen CH, Wang CY, Yang RS, et al.
Review Article Green Tea Sarcopenia Green Tea Catechin ArthritisGreen tea catechins potentially contribute to maintaining joint and skeletal muscle health, mitigating symptoms of osteoarthritis and sarcopenia.
Apitherapy for Age-Related Skeletal Muscle Dysfunction (Sarcopenia): A Review on the Effects of Royal Jelly, Propolis, and Bee Pollen
2020 Sep 25 Foods Ali AM, Kunugi H
Bee products, rich in antioxidants and with versatile pharmacological activities, have shown varying positive effects on muscle mass, strength, and function in laboratory animals and limited human studies. Potential mechanisms include reducing inflammation and oxidative damage, promoting metabolic regulation, enhancing satellite stem cell responsiveness, improving muscular blood supply, inhibiting catabolic genes, and promoting peripheral neuronal regeneration.
Review Article Bee Pollen Sarcopenia
Glutamine: Metabolism and Immune Function, Supplementation and Clinical Translation
2018 Oct 23 Nutrients Cruzat V, Macedo Rogero M, Noel Keane K, Curi R, Newsholme P
Review Article Rice Congee GlutaminePresentation Slides
Iron deficiency promotes a shift towards a more glycolytic metabolism, without detectable effect on mitochondrial bioenergetics, which can be corrected with iron supplements.
Green tea catechins potentially contribute to maintaining joint and skeletal muscle health, mitigating symptoms of osteoarthritis and sarcopenia.
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Glutamine not congee? — 1 Oct 2021