This article contains findings obtained from research on animals:
- The results from animal research studies should not be directly applied to humans and the results may not generalise to the human population.
- There may be significant differences between species in terms of physiology, physiology, and pharmacology, as well as differences in the way diseases and treatments are modelled in animals.
- Any conclusions drawn from animal research should be considered with caution and in the context of other types of research studies such as observational studies, clinical trials, and reviews of the literature.
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Honey intake has observed beneficial effects on various health aspects like cardiovascular, metabolic risk factors, and wound healing, primarily replacing other sweeteners.
2023 Nutrients A Comprehensive Review of the Effect of Honey on Human Health Palma-Morales M, Huertas JR, Rodríguez-Pérez C
Review Article Cardiovascular Disease Honey Metabolic Syndrome
In this comprehensive review study, the researchers went beyond just looking at one or two aspects of health; instead, they embarked on an ambitious task of reviewing forty-eight clinical trials that were published between 1985 and 2022, involving a total of 3655 subjects. The researchers aimed to critically analyze the effect of honey on multiple health indices, including, but not limited to, cardiovascular and metabolic risk factors, glucose tolerance, mucositis inflicted by chemo-radiotherapy, cough in children, and wound healing.
The evaluation and analysis of the data involved a thorough examination of the results of each of the clinical trials, consideration of several potential variables, and detailed cross-study comparisons. This broad and deep investigation allowed the researchers to draw correlations and pinpoint the beneficial influences of honey, considered a nutritious and natural food.
The results from these clinical trials saw more beneficial effects on health from honey intake when compared to neutral or negative outcomes. It was most notably effective, particularly when used as a substitute for other sweeteners. The review also pointed out the potential use of honey as a safe adjuvant to be used in combination with drugs for specific illnesses. Confidently stating that honey has clear benefits in the clinical trials analyzed, the researchers fostered a promising narrative for the further exploration and acceptance of honey as a health booster.
Honey accelerates the healing of diabetic foot ulcers, reduces wound size, and lowers the rates of amputation or hospitalisation, making it a cost-effective and safe treatment.
2023 Applied Sciences Honey Therapy in Diabetic Foot Ulcers: A Promising Strategy for Effective Wound Healing Bezerra A, Fonseca H, Rodrigues F, Delerue-Matos C, Gouvinhas I, Garcia J
Review Article Diabetic Foot Ulcer Honey Wound Healing
The methodology of the review incorporated studies exploring the effects of honey on wound healing, emphasizing its impact on diabetic foot ulcers (DFUs). Different types of honey and their potential influence on treatment efficacy were considered. The review also scrutinised the mechanisms by which honey promotes wound healing and how honey dressings are utilized in the management of diabetic wounds. Nonetheless, it was noted that few of the studies provided comprehensive data regarding the specific characteristics of the employed honey, affecting the comparison across honey types.
The discussion of the results found in most clinical studies indicated that DFUs treated with honey resulted in rapid wound healing, substantial wound contraction, and decreased rates of amputation or hospitalisation. The properties of honey - serving as an effective antibacterial agent against multidrug-resistant bacteria and fostering wound healing through its physical-chemical attributes - were found to be the underlying reasons for these positive outcomes. Furthermore, honey was deemed to be a cost-effective and safe option for managing DFUs.
Honey dressing significantly promotes healing and reduces recovery time in managing diabetic foot ulcers.
2023 Journal of Tissue Viability Use of honey in diabetic foot ulcer: Systematic review and meta-analysis Yildiz Karadeniz E, Kaplan Serin E
Systematic Review Diabetic Foot Ulcer Diabetic Foot Ulcers Honey
For the research methodology, the study used a combination of randomized controlled trials, quasi-experimental, and cross-sectional studies. Only the randomized controlled trials and quasi-experimental studies were chosen for the meta-analysis, while observational studies were subject to a descriptive analysis.
In terms of the results discussion, the meta-analysis indicated that using honey as a dressing for diabetic foot ulcers resulted in a reduction in wound recovery time, pain experienced, duration of hospital stay, and an acceleration in wound granulation. Therefore, it was concluded that honey dressing is an effective intervention for accelerating healing in diabetic foot ulcers.
Phenolic extracts from turmeric and ginger have significant anti-inflammatory effects and enhance wound healing in Wistar rats.
2023 Cosmetics Effect of Phenolic Compounds Extracted from Turmeric (Curcuma longa L.) and Ginger (Zingiber officinale) on Cutaneous Wound Healing in Wistar Rats Bouchama C, Zinedine A, Rocha JM, Chadli N, El Ghadraoui L, Chabir R, et al.
Experimental Study Anti-Inflammatory Ginger Wound Healing
The study utilised the solid-liquid extraction method to obtain phenolic extracts from turmeric and ginger rhizomes. Using Wistar rats as a biological model, the researchers examined the anti-inflammatory effects of the extracts by observing the decrease in edema volume in the rat's hind paw following treatment. Moreover, the healing process of purposefully induced burns on the rat's dorsal region was monitored to evaluate the healing activity.
In the discussion of the results, it was observed that the application of creams containing the mentioned extracts resulted in complete healing after 19 days, a marked improvement compared to the control group, which only achieved 60% healing. The extracts demonstrated different levels regarding tissue repair at day 14, showing their respective potency. The study also identified diverse molecular weight distribution of phenolic compounds within the extracts, suggesting potential influence on how they affect anti-inflammatory and wound healing activities.
Pomegranate juice extract (PPJE) appears to reduce chemotherapy-induced skin side effects by inhibiting inflammation and promoting wound repair on the skin.
2021 Antioxidants Protective Effect of Pomegranate on Oxidative Stress and Inflammatory Response Induced by 5-Fluorouracil in Human Keratinocytes Rapa SF, Magliocca G, Pepe G, Amodio G, Autore G, Campiglia P, et al.
Experimental Study Chemotherapy Oxidative Stress Pomegranate
In this study, the impact of pomegranate (L.) juice extract (PPJE) on skin cells treated with 5-Fluorouracil (5-FU), an antineoplastic agent, was evaluated. This involved assessing the extract's ability to inhibit the release of reactive oxygen species and enhance the cellular antioxidant response of the treated skin cells. Specific attention was given to observe the overexpression of cytoprotective enzymes such as heme oxygenase-1 and NAD(P)H dehydrogenase [quinone] 1 after the introduction of PPJE.
The results indicated that PPJE indeed blocked the formation of nitrotyrosine and reduced the release of cytokines, therefore indicating a dampened inflammatory response. Furthermore, it was revealed that the extract could inhibit the nuclear translocation of p65-NF-κB, a key regulator of inflammation. The study also pointed out that PPJE could curb apoptosis in cells treated with 5-FU, whilst fostering wound repair. The overall findings suggest that PPJE holds potential as a supplementary agent for managing oxidative and inflammatory issues associated with chemotherapy-induced skin side effects.
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