Hypothyroidism
Recent Insights
Olive oil and leaf extract derivatives have been demonstrated to stimulate thyroid function in animal studies.
Hypothyroidism Olive
Chinese medicine warming and invigorating drugs combined with levothyroxine may improve treatment of hypothyroidism caused by Hashimoto disease more than levothyroxine alone.
Hashimoto Disease Hypothyroidism Thyroid Disease
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Research Articles
Published research studies are articles that present the findings of original research that has undergone a peer-review process and has been made publicly available in scholarly journals, books or other media.
Myrtle: a versatile medicinal plant
2023 Feb 16 Nutrire Gorjian H, Khaligh NG
The study concludes that myrtle has multifaceted pharmacological effects, including antioxidant, antibacterial, and anti-inflammatory activities, and it holds potential in various fields such as COVID-19 management, diabetes, liver protection, hypertension, and as a natural remedy for certain health conditions.
Review Article
Research Progress on the Mechanism of Reducing Toxicity and Increasing the Efficacy of Sini Decoction Compatibility
2022 Dec 01 Chemical and Pharmaceutical Bulletin Chen H, Huang Y, Liu H, Yang M, Tong H, Gong F, et al.
The results showed that Sini Decoction (SND) performed remarkbly on strengthening heart, promoting blood circulation as well as inhibiting cardiomyocyte apoptosis, anti-inflammatory and anti-hypothyroidism.
Si Ni San
Green tea extract modulates lithium-induced thyroid follicular cell damage in rats
2022 Aug 24 Folia Morphologica Zaki SM, Hussein GHA, Helal GM, Arsanyos SF, Abd Algaleel WA
Prolonged use of LC results in hypothyroidism, which is accompanied by structural thyroid damage. LC induced thyroid damage through oxidative stress that prompted sterile inflammation and apoptosis. With the use of GTE, the thyroid gland regained its structure and function. The protecting role of GTE is through antioxidant, antifibrotic, anti-inflammatory, and antiproliferative effects.
Animal Study Hypothyroidism
Emerging therapeutic role of Prunella vulgaris in thyroid disease
2022 Jul Chinese Herbal Medicines Zhang W, Wuhan Q, Na M, Hu R, Mu Q, Bao X
Herbs such as P. vulgaris have great potential for treating thyroid disorders owing to their anti-oxidation and immunological effects and are frequently used as ingredients in herbal recipes. P. vulgaris is thought to combat drug toxicity within the body, therefore its own active ingredients have attracted much attention. The use of P. vulgaris with other drugs resulted in significant elimination of swollen nodules, reduced inflammatory response, and improved thyroid function. These effects of P. vulgaris benefit the clinical treatment of thyroid disease while having reduced drug-induced side effects and improved therapeutic effects. However, with only a few studies presenting treatment with Prunella vulgaris alone, further investigation is needed to to explore the physiological mechanisms.
Review Article Xia Ku Cao
Case report – Acupuncture treatment in subclinical hypothyroidism
2021 Aug 06 Journal of Chemical, Biological and physical sciences Blagica Arsovska, Jihe Zhu, Kristina Kozovska
Acupuncture treatment, consisting of 11 sessions over a 3-month period, demonstrated promising results in the management of subclinical hypothyroidism. Before the treatment, the patient's TSH level was elevated at 9.19 mIU/L, and it decreased to 3.70 mIU/L during the treatment, ultimately normalizing to 3.09 mIU/L after completion. The selected acupuncture points targeted the thyroid and related meridians. The study suggests that acupuncture, as part of Traditional Chinese Medicine, can provide rapid and positive outcomes in improving thyroid function and overall body energy in cases of subclinical hypothyroidism.
Clinical Study Case Report HypothyroidismResearch Insights
Insights are moderated by the Research Hub team and offer an at-a-glance overview of interesting research findings.
Olive oil and leaf extract derivatives have been demonstrated to stimulate thyroid function in animal studies.
2021 Nutrients Thyroid-Modulating Activities of Olive and Its Polyphenols: A Systematic Review Pang KL, Lumintang JN, Chin KY
Systematic Review Olive
In October 2020, a systematic review of literature was conducted to study the effects of olive oil and leaf extract derivatives on thyroid function. The search for relevant information was done using PubMed, Scopus, and Web of Science databases. Evidence was gathered from cellular, animal, and human studies that reported on the impact of these derivatives on thyroid function. 445 articles were identified but only nine were considered based on inclusion and exclusion criteria.
All the chosen articles were animal studies involving the oral administration of olive oil, olive leaf extract, or olive pomace residues. The results consistently indicated that these olive derivatives stimulated thyroid activities in euthyroid or hypothyroid animals. The exact mechanisms by which this occurs remain unknown. From the studies evaluated, olive pomace residue was found unsuitable for health supplementation or pharmaceutical use. Despite encouraging results, there isn't much evidence proving beneficial health effects of olive derivatives in humans, and the therapeutic applications particularly in individuals with hypothyroidism, needs further support through human studies.
Findings indicated reductions in patient symptoms and improvements in biomarkers where acupuncture was used alone or in combination therapy against thyroid-relevant illnesses.
2018 Journal of Integrative Medicine An overview of the contribution of acupuncture to thyroid disorders Cheng FK
Systematic Review Thyroid Disease
Analysing 29 clinical projects that were retrieved from 29 major digital databases and include 1757 patients aged 7–79 years from China, Italy, Korea, Macedonia and Russia, this narrative review offers an overview of the efficacy, and evaluated the safe and cost-effective use of acupuncture against hyperthyroidism, hypothyroidism and thyroid-relevant illnesses. Findings indicated reductions in patient symptoms and improvements in biomarkers where acupuncture was used alone or in combination therapy. In addition to showing the role of acupuncture as an alternative and complementary medicine or as an adjunctive therapy for curative and rehabilitative purposes, more well-designed researches are needed to achieve reliable data.
Chinese medicine warming and invigorating drugs combined with levothyroxine may improve treatment of hypothyroidism caused by Hashimoto disease more than levothyroxine alone.
2016 Annals of Translational Medicine A systematic review of combinatorial treatment with warming and invigorating drugs and levothyroxine for hypothyroidism caused by Hashimoto disease Xiangwen Cheng, Zixiao Wei, Guangde Zhang, Xin Shao, Bo Li, Rui Gao
Systematic Review Hashimoto Disease Thyroid Disease
This systematic review pooled several indices of hypothyroidism caused by HT according to “China’s Guidelines for the Diagnosis and Treatment of Thyroid Disease” and correlation studies. The results showed that the combination of warming and invigorating drugs and levothyroxine increased FT3 and FT4 levels, and reduced TSH, TPOAb, and TGAb levels in patients with hypothyroidism cause by HT more than levothyroxine alone after treatments of 8 weeks or longer. With the exception of FT4, the results were stable.
In conclusion, we cautiously recommend prescribing warming and invigorating drugs along with levothyroxine for the treatment of hypothyroidism caused by Hashimoto disease. However, high-quality evidence is needed to confirm these results. To guarantee evidence quality, a strict study design, which includes a large sample, an unbiased randomization method, full concealment, proper blinding, and appropriate statistical analyses, is vital. In addition, clinical curative effects of TCM, such as TCM syndromes, should be standardized and unified to reduce clinical heterogeneity and methodology heterogeneity. Finally, a strict registration system for clinical trials is required to remove reporting biases.
Review Articles
Review articles summarise and critically evaluate the current state of research on a specific topic or field by synthesising multiple primary research studies.
Myrtle: a versatile medicinal plant
2023 Feb 16 Nutrire Gorjian H, Khaligh NG
The study concludes that myrtle has multifaceted pharmacological effects, including antioxidant, antibacterial, and anti-inflammatory activities, and it holds potential in various fields such as COVID-19 management, diabetes, liver protection, hypertension, and as a natural remedy for certain health conditions.
Review ArticleEmerging therapeutic role of Prunella vulgaris in thyroid disease
2022 Jul Chinese Herbal Medicines Zhang W, Wuhan Q, Na M, Hu R, Mu Q, Bao X
Herbs such as P. vulgaris have great potential for treating thyroid disorders owing to their anti-oxidation and immunological effects and are frequently used as ingredients in herbal recipes. P. vulgaris is thought to combat drug toxicity within the body, therefore its own active ingredients have attracted much attention. The use of P. vulgaris with other drugs resulted in significant elimination of swollen nodules, reduced inflammatory response, and improved thyroid function. These effects of P. vulgaris benefit the clinical treatment of thyroid disease while having reduced drug-induced side effects and improved therapeutic effects. However, with only a few studies presenting treatment with Prunella vulgaris alone, further investigation is needed to to explore the physiological mechanisms.
Review Article Xia Ku CaoThyroid-Modulating Activities of Olive and Its Polyphenols: A Systematic Review
2021 Feb 06 Nutrients Pang KL, Lumintang JN, Chin KY
Systematic Review Olive HypothyroidismOlive oil and leaf extract derivatives have been demonstrated to stimulate thyroid function in animal studies.
An overview of the contribution of acupuncture to thyroid disorders
2018 Nov Journal of Integrative Medicine Cheng FK
Systematic Review Randomised Controlled Trial Thyroid DiseaseFindings indicated reductions in patient symptoms and improvements in biomarkers where acupuncture was used alone or in combination therapy against thyroid-relevant illnesses.
Traditional Chinese Medicine Approach to Hypothyroidism
2017 Jan 3 International Journal of Complementary and Alternative Medicine Malikov D
Review Article Thyroid DiseaseClinical Trials
Clinical trials are research studies that involve people and are conducted to evaluate the safety and efficacy of new treatments or interventions, such as drugs, medical devices, or behavioural therapies.
Study Protocols
Published study protocols are detailed plans that outline the objectives, methodology, statistical analyses, and organisation of a research study that have been made publicly available for others to review and use as a reference.
Presentation Slides
Olive oil and leaf extract derivatives have been demonstrated to stimulate thyroid function in animal studies.
Findings indicated reductions in patient symptoms and improvements in biomarkers where acupuncture was used alone or in combination therapy against thyroid-relevant illnesses.
Chinese medicine warming and invigorating drugs combined with levothyroxine may improve treatment of hypothyroidism caused by Hashimoto disease more than levothyroxine alone.
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