Antioxidant

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Executive Summary

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Write an executive summary in the form of a blog article on the topic of "Research into Chinese medicine treatment for Antioxidant" summarising the research below and using language that can be easily understood by patients and avoiding medical jargon using a professional and caring tone of voice.

Write an executive summary in the form of a blog article on the topic of "Researched Chinese medicine treatments for Antioxidant" summarising the research below in an objective and easy to understand way, and using language that can be easily understood by patients. Group the article into Chinese medicine treatments first, followed by nutrition and other treatments. Avoid using medical jargon and use a professional and caring tone of voice.

Write me a concise but easy to understand executive summary on the topic of "Chinese medicine treatments for Antioxidant" based on the following research that I will give you. Your summary should be 2 paragraphs long in Australian English spelling and include references to the studies.

A Review Article published in 2024 in the journal The Natural Products Journal found that Pumpkin seeds are recognised for their medicinal, nutritional, and cosmetic benefits, including anti-diabetic, heart disease prevention, anti-cancer, and antioxidant qualities. The review article undertakes a comprehensive exploration of the nutraceutical importance of pumpkin seeds. The methodology includes an examination of the various known substances in the seeds, such as phytoestrogens, unsaturated fatty acids, and vitamin E. The study then delves into the different benefits and therapeutic uses of these components stretching from medicinal to nutritional to cosmetic applications. The results of this research are diverse and impressive, with implications for several major health sectors. Their potential anti-diabetic and hypoglycemic properties could suggest a significant role in the management and prevention of diabetes. Meanwhile, the seeds' potential in cardiovascular disease prevention could help to address one of the most pressing global health issues. Moreover, potential anti-cancer properties imply that these seeds could even have a part to play in cancer prevention. The review also described potential additional qualities, such as antidepressant, anti-helminthic (parasite-removing), and antioxidant effects.

A Experimental Study published in 2023 in the journal Journal of Science and Technology - HaUI found that The compound (Z)-5’-Hydroxyjasmone 5’-O-β-D-Glucopyranoside from chrysanthemum flowers demonstrated superior antioxidant and anti-osteoporosis effects. The research involved isolating five compounds from Chrysanthemum indicum L flowers: Syringin, Dihydrosyringin, Benzyl-O-β-D- glucopyranoside, -Phenylethoxy-O--D-glucopyranoside, and (Z)-5’-Hydroxyjasmone 5’-O-β-D-Glucopyranoside. The identification and structure determination of these compounds were performed via the interpretation of their 1D - NMR spectra and comparison to established literature. The collected compounds were then assessed for their antioxidative and anti-osteoporosis activities. During the analysis of results, it was observed that the compound (Z)-5’-Hydroxyjasmone 5’-O-β-D-Glucopyranoside exhibited significantly higher antioxidant activity and anti-osteoporosis effects compared to the others. It showed a strong capacity for peroxyl radical scavenging, surpassing the protection offered by the standard Trolox. Dihydrosyringin also demonstrated a good reducing capacity, as indicated by its CUPRAC values. Furthermore, (Z)-5’-Hydroxyjasmone 5’-O-β-D-Glucopyranoside displayed strong inhibitory effects on osteoclast differentiation, indicating its potential as an anti-osteoporosis agent.

A Review Article published in 2023 in the journal Molecules found that Bee pollen showcases a range of biological activities, such as anti-inflammatory, antimicrobial, and potential antiviral properties, which could contribute to the creation of innovative therapies. The methodology used in the study involved analysing a diverse array of pollen types, in combination with their various chemical compositions. The primary aim of this was to updatedly assess the bioactive constituents present in bee pollen and consider the therapeutic possibilities they present. A focus of the study was on beehive pollen since it is a rich natural source of proteins and nutrients and exhibits immense chemical and therapeutic potential. Discussion of results emphasized that the range of biological activities associated with bee pollen is truly remarkable. This activity ranges from anti-inflammatory and antimicrobial properties to potential antiviral and anticancer applications. Despite the challenge presented in fully understanding the vast array of biological properties across various pollen sources, this study has succeeded in emphasizing the potential extent of the therapeutic effectiveness of bee pollen. Its potential contribution on the path to discovering innovative therapies cannot be underestimated.

A Randomised Controlled Trial published in 2023 in the journal Journal of Medicinal Food found that Daily consumption of pecans for a month can help protect against post-meal oxidative stress in aging adults. The abstract outlines a randomized, parallel, controlled trial where 41 healthy adults aged between 50 and 75 were split into two groups. One group consumed 68 grams of pecans every day for four weeks, while the other group avoided all nuts. Blood samples were obtained from all participants before and after the intervention during fasting and at intervals of 30, 60, and 120 minutes after a meal high in saturated fats. Changes were observed in various parameters, including malondialdehyde - a marker for lipid peroxidation, total antioxidant capacity (TAC), glucose, and insulin levels. The study revealed no significant variances in fasting or post-meal TAC, glucose, or insulin for the pecan consumers compared to the control group. However, there was a noticeable tendency towards a change in fasting lipid peroxidation driven by a minor reduction for the pecan group compared to the control group. Moreover, post-meal lipid peroxidation was suppressed in the pecan group, distinctly different from the control group's results. These outcomes propose that a diet enriched in pecans for one month can provide protection against post-meal oxidative stress in older adults.

A Review Article published in 2023 in the journal International Journal of Food Properties found that Plums, which are rich in bioactive compounds, antioxidants, and vitamins, can help maintain blood glucose level, bone health, heart health and even treat certain cancers. The research explored the health benefits and medicinal effects of plums, a common fruit belonging to the Prunus genus. The study focused not only on their consumption as a food source but also their uses in beverages. Special attention was given to the polyphenolic compounds, bioactive compounds, and antioxidants inherent in plums, such as phenolic acids, anthocyanins, carotenoids, and various organic acids, alongside an array of necessary minerals and vitamins. Apart from detailing traditional nutritional components, the study analyzed the unique constituents of plums like caffeic acid, chlorogenic acid and other phenolic compounds which contribute to its antioxidant property. The broader health benefits provided by these compounds spanning bone health, cardiovascular health, blood glucose stabilization, and potential impacts on gastrointestinal diseases were studied, with a particular emphasis on their possible role in the prevention and treatment of heart disease and specific kinds of cancer: lung and oral. The role of plums' low fat and high dietary fibre content in heart disease prevention was of special focus.

A Network Pharmacology published in 2023 in the journal Journal of Ethnopharmacology found that Gold kiwifruit extracts contained different bioactive materials which showed selective cytotoxic activity against human oral tumor cells and displayed anti-HIV, antioxidant, and antibacterial activities. The methodology involved stepwise extraction of gold kiwifruit with hexane, acetone, methanol, and 70% methanol; the extracts were then fractionated using silica gel and ODS column chromatographies to examine their biological activities. Different fractions like H1, H2 (from the hexane extract), A1, A2 (from the acetone extract), and M2 (from the methanol extract) were tested, as well as more hydrophilic fractions from the 70% methanol extract. In the discussion of the results, fractions H1, H2, A1, A2 and M2 displayed notable cytotoxic activity against human oral tumor cell lines, with these showing more sensitivity compared to human gingival fibroblasts. The hydrophilic fractions from the 70% methanol extract demonstrated higher anti-HIV activity, radical generation, and oxygen scavenging activity. However, the antibacterial activity of these fractions was generally lower than that of the more lipophilic (hexane, acetone, methanol) extracts, indicating no distinct antimicrobial action. Interestingly, all fractions were inactive against Helicobacter pylori.

A Experimental Study published in 2023 in the journal Biomedicine & Pharmacotherapy found that Zhangyanming Tablets show potential as a protective agent for retinal function in early-stage, genetically-caused blindness in mice, possibly due to their antioxidant and anti-/pro-apoptotic properties. Eighty mice with Retinitis Pigmentosa (RP) were divided into two groups, with one group receiving Zhangyanming Tablets (ZYMT) and a control group getting distilled water. After a period of 7 and 14 days, the researchers conducted tests through electroretinogram, fundus photography, and histological examination to assess the retinal function and structure of the subjects. They furthered the study using TUNEL, immunofluorescence and qPCR to evaluate cell apoptosis and the expressions of particular genes. The ZYMT-treated mice displayed a notable enhancement in retinal reactions and overall preservation of retinal structure when compared to the control group. Particularly noticeable were increases in retinal thickness and cell count, alongside a significantly lowered rate of cell death. A comprehensive follow-up shows the altered expressions of several genes in the retina following the application of ZYMT. These results, combined, suggest a key role of ZYMT in mitigating the effects of RP especially in early stages.

A Clinical Study published in 2023 in the journal Biomedical Reports found that Consuming a honey-based gel, such as 'Bear Strength honey gel,' led to a notable reduction in diastolic and mean arterial blood pressure, with gender-specific improvements in redox status among healthy adults. The study included 20 healthy participants (10 men, 10 women) who incorporated 70g of 'Bear Strength honey gel' into their daily diet for 14 days. Physiological parameters (weight, height, BMI, body fat, waist-to-hip ratio, resting heart rate, and blood pressure) and hematological data were evaluated before and after consumption. Redox biomarkers, including Glutathione (GSH), catalase (CAT), total antioxidant capacity (TAC), protein carbonyls (PCARBS), and thiobarbituric reactive substances (TBARS), were measured. Post-consumption, the honey-based gel showed a significant decrease in diastolic and mean arterial blood pressure, particularly in women. However, no significant changes were observed in other physiological or hematological variables. Notably, GSH levels increased in both genders, TAC increased universally, and TBARS levels decreased in the total group and women. PCARBS levels decreased exclusively in the women's group. These findings highlight the honey-based gel's potential positive impact on blood pressure and redox status, emphasizing gender-specific effects in healthy adults.

A Experimental Study published in 2023 in the journal Egyptian Journal of Chemistry found that Chrysanthemum morifolium contains natural bioactive compounds, including 29 types of phenolics, which display significant antioxidant activity. The study determined the antioxidant properties of Chrysanthemum morifolium by using methanol and ethyl acetate as solvents to extract and then analyse the plant's phenolic profile. The antioxidant activity was assessed with three separate in vitro tests: a reducing power assay, a Phosphomolybdenum antioxidative power assay, and the testing of inhibition of free radical 1,1-di phenyl-2-picryl hydrazyl. The content of total phenolics and total flavonoids was measured using the Folin Ciocalteu reagent, yielding a range of values. In relation to the results, it was established that the examined plant was a significant source of bioactive compounds with notable antioxidant properties. A total of 29 phenolics, divided into 15 phenolic acids and 14 flavonoids were identified and quantified using high-performance liquid chromatography. Ellagic acid was the most present phenolic in the methanol extract and ethyl acetate fraction of green aerial parts. Meanwhile, Hesperidin was the most common flavonoid in the flower methanol extract. The ethyl acetate fraction from the flowers showed the highest efficiency in all tested antioxidant methods, indicating that different parts of the plant can vary in their antioxidant potential.

A Review Article published in 2023 in the journal Food Reviews International found that Australian native plums contain phytochemicals that exhibit health benefits such as cardiovascular and liver protection. The research review examined five varieties of Australian native plums: Terminalia ferdinandiana (Kakadu Plum), Davidsonia jerseyana (Davidsons Plum), Podocarpus elatus (Illawarra Plum), Pleiogynium timorense (Burdekin Plum) and Parinari nonda (Nonda Plum). The paper explored each plum variety in terms of their ideal growing conditions, their phytochemical composition, their sensory properties, and their potential applications. Extracts from different parts of the fruit including the peel, pulp, and seeds were analyzed for their capabilities to interact with cell signaling pathways, scavenge free radicals, and inhibit harmful microorganisms such as bacteria, fungi, and viruses. The findings suggest that Australian native plums not only have substantial nutritional value - being high in dietary fiber and low in fat - but they also offer a multitude of health benefits. Notably, these fruits exhibit cardiovascular and liver-protective properties. Moreover, aside from their nutritional and health value, these native plums also display impressive economic potential. For instance, the pulp of these plums could be incorporated into food and beverage creation while their wood could be utilized for furniture making.

A Systematic Review published in 2023 in the journal Frontiers in Medicine found that Saffron supplementation significantly decreased oxidative stress markers and has beneficial effects in reducing oxidative stress. For this analysis, we sought to evaluate the impact of saffron supplementation on oxidative stress markers, including malondialdehyde, total antioxidant capacity, total oxidant status, glutathione peroxidase, superoxide dismutase, and prooxidant/antioxidant balance. To do this, we conducted an extensive search across databases such as PubMed/Medline, Web of Science, Cochrane CENTRAL, Scopus, and Google Scholar until December 2022. Our search criteria included randomized controlled trial studies examining the effects of oral saffron supplements on the aforementioned oxidative stress markers. The resulting data were pooled using a random effects model to analyze the results, and we assessed heterogeneity using the Cochrane values. We incorporated 16 cases into our meta-analysis, which comprised of subjects in both saffron and control groups. In our results, we found that saffron consumption resulted in significant reductions in malondialdehyde and total oxidant status levels. Furthermore, it led to a considerable increase in total antioxidant capacity and glutathione peroxidase - all of which are markers indicating oxidative stress. More specifically, within studies where the daily dosage of saffron was greater than 30 mg, and in studies lasting less than 12 weeks, we noted a significant reduction in malondialdehyde levels, especially in participants under 50 years old. Our study faced limitations, including the geographical limitation of the studies being from Iran, the varying nature of the diseases included, and potential confounding factors such as smoking, physical activity, and diet.

A Clinical Study published in 2023 in the journal Molecules found that Chrysanthemum extract can be utilised as a natural ingredient to lessen post-meal cholesterol levels and enhance antioxidant status, after eating a high-fat meal. The researchers analyzed the composition of two types of Imperial Chrysanthemum (IC) extracts, specifically IC-P and IC-E, using an Ultra High-Performance Liquid Chromatography-Mass Spectrometry (UHPLC-MS) method. Next, they assessed these extracts' in vitro antioxidant activities using three different radical scavenging assays: 1,1-diphenyl-2-picrylhydraxyl (DPPH), 2,2-azino-bis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) and Hydroxyl Radical(HR). A group of 37 adults followed a randomized program and were divided into two: one consuming a high-fat (HF) meal alone and the other having the same meal but supplemented with IC extract. Blood samples from participants were taken at a fasting state and several more times up to 8 hours after the meal. The study found 12 compounds, including amino acids, flavonoids, and carboxylic acids, making up over 1% of the IC extracts. Compared to IC-E, IC-P exhibited significantly higher flavonoid content and strong free radical scavenging activity. Chrysanthemum consumption showed significant differences in post-meal glucose levels, triglycerides, total antioxidant capacity (T-AOC), and malondialdehyde (MDA) levels, with the IC-P supplement group showing lower postprandial glucose and improved serum antioxidant status.

A Systematic Review published in 2022 in the journal Frontiers in Nutrition found that Antioxidant therapy significantly reduces disease-related symptoms for patients with knee osteoarthritis. Methodology: The approach for this systematic review and meta-analysis was based on thorough literature analysis with no time or language restrictions from prominent databases including PubMed, International Scientific Indexing, and Scopus. The search was focused on the connections between "osteoarthritis" and "antioxidants". This study considered pain as the primary outcome while also analyzing the symptoms, functions of knee osteoarthritis, and quality of life. All these variables were measured using the corresponding instrument from existing studies. Only randomized controlled trials with a placebo control or other medical therapeutic interventions were included. Publication bias was evaluated using Begg's funnel plot and Egger's regression test, and results were validated using the trim-and-fill test. Results: From the initial 7,698 papers, information was obtained from 31 selected documents. Results showed that antioxidant therapy significantly affected the symptoms of patients with knee osteoarthritis, as validated using the Visual Analog Scale. However, there was no notable difference observed in the combined score, difficulty score, pain score, and stiffness score as reported by the Western Ontario and McMaster Universities Osteoarthritis Index.

A Review Article published in 2022 in the journal Journal of Functional Foods found that Carrot's bioactive compounds can regulate immune response, reduce oxidative stress, and prevent damaging oxidative destruction, making it a potential preventive tool for various diseases. In this literature review, mechanisms were proposed for how the antioxidant properties of carrot’s β-carotene and other bioactive compounds, such as phenolic acid, flavonoid, polyacetylene, and ascorbic acid could modulate the immune system. These proposals were centered around three main paths: anti-inflammatory response modulation, antioxidant response modulation, and overall immune response modulation (which involves both innate and adaptive responses). In the discussion of results, it was revealed that the bioactive compounds in carrots have the ability to regulate pro-inflammatory and anti-inflammatory cytokines, and are also capable of reducing oxidative stress. This was shown by the decrease in the accumulation of reactive oxygen species and an increase in antioxidant capacity, which collaboratively helps to minimize destructive oxidative destruction. Additionally, these compounds influenced immune components, specifically via the regulation of leukocytes, antigens, immunoglobulins, and histamine levels. As a result, carrots were defined as a functional food source capable of immune modulation and potential prevention and treatment for a range of diseases.

A Animal Study published in 2022 in the journal Food Research International found that Pu-erh tea and its ingredient theabrownin improve liver, jejunum, and adipose tissue functions in metabolic syndrome mice, modulating circadian rhythm, glycerophospholipid, and linoleic acid metabolism. In this study, varied technological applications such as metagenomics, transcriptomics, and metabolomics were utilized to explore the anti-metabolic syndrome mechanism of Pu-erh tea and theabrownin in mice with metabolic syndrome. These scientific technologies allowed the researchers to understand and explore improvements in the physiological functions of liver, jejunum, and adipose tissues in the metabolic syndrome mice as a result of Pu-erh tea and theabrownin interventions. The investigation also focused on changes to the hepatic transcriptome, revealing that both of these interventions had the capacity to regulate the circadian rhythm pathway. The results showcased that both interventions succeeded in the modulation of glycerophospholipid and linoleic acid metabolism, this was established through a comprehensive analysis of serum and brain metabolome. Further analysis of faecal metagenome demonstrated an increase in the relative abundance of certain bacterium and a decrease in others due to both interventions. However, in comparison to Pu-erh tea, theabrownin exhibited a more pronounced influence as regards upregulating hepatic antioxidants and downregulating hepatic inflammatory factors, although there was only a slight reduction in obesity-linked short-chain fatty acids in faeces of the metabolic syndrome mice. Overall, the experiment provided essential insights into the various ways these two elements function and provide treatment for metabolic syndrome.

A Review Article published in 2022 in the journal Molecules found that Green tea's catechins demonstrate therapeutic effects against neurodegenerative diseases via anti-inflammatory, antioxidant actions, and activating diverse brain cellular pathways. The research primarily evaluates the effect of polyphenolic compounds found in green tea, known as catechins, on neurodegenerative diseases. By conducting several interventional and observational studies on humans, the research explores the anti-cancer, anti-obesity, antidiabetic, anti-inflammatory, and neuroprotective properties of these compounds. The biological, pharmacological, antioxidant, and metal chelating abilities of catechins, particularly their influence on different cellular pathways within the brain, are intensively studied. The results elucidate that catechins exhibit multiple neuroprotective effects. Their anti-inflammatory and antioxidant properties help to inhibit excessive production of cytokines, and inflammatory pathways, while also controlling metal ions and free radicals. Researchers have further established that catechins may curb the phosphorylation of the tau protein and aggregation of amyloid beta, both key markers in neurodegenerative diseases. Additionally, these compounds show potential in reducing alpha-synuclein levels and augmenting dopamine levels. Hence, they significantly contribute to the prevention and treatment of neurodegenerative diseases, including Alzheimer's, Parkinson's, multiple sclerosis, and cognitive deficits.

A Randomised Controlled Trial published in 2022 in the journal Antioxidants found that Pomegranate extract consumption improves antioxidant levels, reduces oxidative stress and cardiovascular risk factors including blood pressure and body fat, and increases lean body mass. In the study, 24 healthy participants were divided into two groups: one consumed a natural standardized pomegranate extract, while the other, a placebo, in a randomized, single-blind placebo-controlled trial. Evaluations were conducted at baseline and post 14 and 28 days of the experiment, with variables including anthropometric measurements, blood pressure, pulse wave speed, body composition, as well as the levels of salivary and urinary cortisol, cortisone, total phenolics, antioxidant capacity, and lipid peroxidation. The results indicated significant increases in urinary total phenolics excretion and antioxidant capacity after 14 and 28 days of pomegranate extract intake. By day 28, notable decreases were noted in systolic and diastolic blood pressure, pulse wave velocity, body fat and fat mass, and an increase in lean body mass. In terms of glucocorticoid levels, there was a marked decrease in saliva cortisol at day 28 in the morning for the pomegranate extract group, along with a decrease in the cortisol/cortisone ratio following 28 days of pomegranate extract intake at morning, noon, and evening. Reductions were also seen in urine free cortisol levels by day 14. These observations were unique to the pomegranate extract group, with no significant changes noted in the placebo group.

A Network Pharmacology published in 2022 in the journal Antioxidants found that Kelulut honey, either alone or in combination with metformin or clomiphene, can alleviate oxidative stress and reproductive and metabolic abnormalities in rats with polycystic ovary syndrome. To examine the effects of Kelulut honey (KH), metformin, and clomiphene on polycystic ovary syndrome (PCOS), female Sprague-Dawley rats were treated with letrozole to stimulate symptoms of PCOS. The rats were then split up into six groups, each group undergoing a different kind of treatment for a period of 35 days, including KH alone, metformin alone, clomiphene alone, KH combined with metformin, and KH combined with clomiphene. The physicochemical characteristics of the honey were assessed using several tests, and its semi-volatile organic compounds were determined via gas chromatography-mass spectrometry. KH and its combinations with either metformin or clomiphene were found to improve the hormonal profile and ease oxidative stress in the rats. However, while the treatments seemed to improve the oestrus cycle, they reportedly did not affect fasting blood glucose, insulin levels, or body weight in the test subjects.

A Systematic Review published in 2022 in the journal Advances in Nutrition found that Prunes demonstrate potential as a dietary intervention to protect against, prevent and even reverse bone loss in osteoporosis, particularly in postmenopausal women. Using sixteen preclinical trials with in vivo rodent models of osteopenia or osteoporosis, researchers investigated the effect of dietary supplementation with prunes. The research shows prunes' osteoprotective capabilities, preventing, reversing bone loss, and exerting anti-inflammatory and antioxidant effects. The prunes or their polyphenol extracts showed properties that decreased malondialdehyde and NO secretion and increased antioxidant enzyme expression. Two clinical trials further investigated prune consumption (50-100 g/d for 6-12 months) on bone health in postmenopausal women. The results of the studies revealed the promising outcome of improved bone mineral density and bone biomarker due to the consumption of dried plums. However, the effect of prunes on oxidative stress and inflammatory mediators remains less understood. The study hence emphasizes the need to investigate prunes' role in modulating the inflammatory and immune pathways related to bone health.

A Review Article published in 2022 in the journal Molecules found that Depression, a prevalent and debilitating disorder, necessitates novel treatments beyond conventional drugs. Stingless bee honey, rich in antioxidants, emerges as a potential antidepressant candidate, explored comprehensively through monoamine, inflammatory, and neurotrophin hypotheses. This comprehensive review delves into the urgent need for safer and more effective depression treatments, considering the limitations of conventional drugs. The focus is on Stingless Bee Honey (SBH), recognized for its high antioxidant content, and its potential as an antidepressant is explored through the lenses of the monoamine, inflammatory, and neurotrophin hypotheses. Stingless bee honey's potential as an antidepressant is examined in the context of its antioxidant richness, offering a new avenue for addressing depression beyond conventional drug approaches. The review highlights the importance of exploring alternative medicines, such as SBH, for safer and more efficacious depression treatments.

A Review Article published in 2022 in the journal Applied Sciences found that Honey, owing to its bioactive compounds, demonstrates potential in treating COVID-19 symptoms by reducing oxidative damage and enhancing the immune system. The review outlines the SARS-CoV-2 virus's mechanisms of action, which is responsible for COVID-19, offering a comprehensive understanding. It also explores the various bioactive assets honey has at its disposal, primarily focusing on its beneficial properties. The discussion elaborates on the potentials of honey's biological properties, especially its antioxidant and anti-inflammatory activities. These characteristics of honey, as suggested by the review, could contribute to the relief of oxidative damage and boost the immune system, thereby proving beneficial in combating viral infections, including COVID-19.

A published in 2022 in the journal Foods found that Bananas and plantains contain compounds with anti-inflammatory, anti-apoptotic, and antioxidative properties that hold promise for potentially reversing neurological disorders. The methodology of the study revolved around scrutinizing the bioactive properties found in bananas and plantains. Researchers pinpointed various neuroprotective mechanisms within commonly consumed fruits, specifically bananas and plantains. The study examined protein expression regulation and targeted specific gene pathways, including nuclear and tumor necrosis factors, extracellular signal-regulated and mitogen-activated protein kinases, activator protein-1, and the glial fibrillary acidic protein. In their investigations, they also considered the underutilized peel components of these fruits. The results suggest that the multitude of bioactive compounds found in both the pulp and peels of bananas and plantains perform a variety of beneficial neuroprotective activities. These range from acting as antioxidants, preventing cell death (anti-apoptotic), and reducing inflammation (anti-inflammatory), to directly influencing the functionality of the nervous system (neuromodulatory). This discovery implicates plant-based foods, specifically bananas and plantains, as potentially significant substances in combating, halting, or mitigating the pathological mechanisms underlying neurodegenerative disorders.

A Review Article published in 2022 in the journal Comprehensive Reviews in Food Science and Food Safety found that Pumpkin seed oil, with its phytochemical content, shows beneficial properties against cardiovascular problems in menopausal women and hormone imbalances. The study focused on gathering scientific information that highlights the potential of pumpkin seed oil as a health-benefiting food ingredient. Its focus is on the oil’s chemical composition, phytochemical content, biological activity, safety measures alongside the various production processes. The researchers examined major phytochemicals found in the oil, including polyphenols, phytoestrogens, and fatty acids, while also noting the potential health benefits of carotenoids, squalene, tocopherols, and minerals present in it. In terms of methodology, most studies within this review were conducted in vitro to validate the oil's antioxidant and antimicrobial activities. Furthermore, there were clinical studies undertaken specifically to observe the effect of the oil in addressing cardiovascular challenges in menopausal women and conditions related to sex hormone imbalances. The comprehensive overview covers a wide array of data on the composition and potential uses of pumpkin seed oil.

A Review Article published in 2022 in the journal Journal of Agricultural and Food Chemistry found that Jujube nutrients may offer potential therapeutic benefits including antioxidant, antibacterial, anti-inflammatory functions, and improving sleep quality and learning. The methodology used for this study involves a comprehensive review of existing research about Wild jujube, giving particular focus on its phytonutrients, biological functions, metabolism of bioactive compounds, and applications. The study does not seem to detail a specific experimental procedure, but instead bases its conclusions on existing literature. Various parts of the wild jujube plant, such as the fruits, seeds and leaves, were examined for their potential role as food, medicine, or health care aids. The results from the review suggest that the different parts of the wild jujube plant play many roles. The fruits have been noted for their antioxidant, antibacterial, and anti-inflammatory properties, and as ingredients preventing aging. The mature seeds have been found to have potential beneficial effects on central nervous system diseases, particularly in the treatment of insomnia and the enhancement of learning and memory.

A Review Article published in 2022 in the journal Frontiers in Nutrition found that The underutilized pomegranate peel, full of abundant bioactive substances, could be repurposed for its potential health benefits like anti-inflammatory, anti-cancer, cardiovascular protection, and antibacterial activities. This paper conducts a miniature review of the characterization and physiological functions of the key bioactive compounds present in pomegranate peel. The exploration underscores the main phenolic compounds in the peel, illustrating substances such as tannins, flavonoids, phenolic acids, dietary fibers, alkaloids, minerals, and vitamins. A deep understanding of these components and their potential benefits is vital to the study and future applications. The research finds that these core components essentially function as antioxidants, either enhancing oxidative biomarkers or proactively neutralizing reactive oxygen species. By establishing these key functions, it essentially links these activities to a broader context of benefits, including but not limited to anti-inflammatory, anti-cancer, cardiovascular protection, and antibacterial attributes, thereby indicating a potential for substantial health benefits. With comprehensive understanding and appropriate application of these substances, the pomegranate peels, often classified as waste, could find a new life as robust health-enhancing elements.

A Animal Study published in 2022 in the journal Applied Sciences found that Fermented gold kiwi extract exhibits antioxidant properties, providing protection to the stomach lining and reducing inflammation, making it promising for treating gastritis and gastric ulcers. The researchers created a fermented powder from golden kiwi fruits, a process that enhances the fruit's bioactive compounds including organic acids, flavonoids, and carotenoids. They then studied its effects using animal models, specifically two rat models; one induced with gastritis via HCl/EtOH and the other with pyloric ligation. The goal was to examine the fermented gold kiwi's (FGK) antioxidative activity, appearing in a dose-dependent manner. The obtained results demonstrated the protective effects of FGK in both animal models. The fermented kiwi notably suppressed inflammation biomarkers such as iNOS, COX-2, IL-6, and TNF-α, which are commonly associated with gastritis and gastric ulcers. It also increased the expression of PGE2, a molecule that protects the tissues. FGK was found to not only improve the appearance of the gastric lesion site but also enhance clinical symptoms and mucosal thickness. In the pyloric ligation model, it reduced gastric fluid volume, total acidity, free acidity, and pepsin activity, thereby showcasing overall gastric protective abilities.

A Experimental Study published in 2022 in the journal Antioxidants found that Berries, largely due to their phenolic compounds, enhance internal antioxidant status and positively influence gut microbiota composition, promoting beneficial bacteria and suppressing harmful types. The study compared the antioxidant capacities and gut microbiota modulatory effects of nine popular berries: blackberry, black goji berry, blueberry, mulberry, red Chinese bayberry, raspberry, red goji berry, strawberry, and white Chinese bayberry. The anthocyanin profiles of each berry were identified using Ultra-performance liquid chromatography (UPLC) coupled with Triple TOF/MS. The antioxidant capacities were evaluated through four chemical assays (DPPH, ABTS, FRAP, and ORAC). Healthy mice were treated with different berry extracts for two weeks as a means of investigating in vivo antioxidant capacity and gut microbiota modulatory effects. In terms of the results, it was observed that majority of the berries improved the internal antioxidant status, indicated by elevated serum or colonic Total Antioxidant Capacity (T-AOC), Glutathione (GSH), Total Superoxide Dismutase (T-SOD), Catalase (CAT), and Glutathione Peroxidase (GSH-PX) levels, along with a decrease in Malondialdehyde (MDA) content. All berries studied notably altered the gut microbiota composition, with most leading to the enrichment of beneficial Short Chain Fatty Acids (SCFAs)-producing bacteria and the curbing of potentially harmful bacterial types.

A Review Article published in 2022 in the journal Molecules found that Cherries and blueberries, rich in phenolic compounds, can be effectively used in pharmaceutical products, smart foods, functional beverages, and nutraceuticals to prevent or treat diseases. The research primarily studied the health-promoting potential of cherries and blueberries, given their high nutritional density and substantial phenolic compounds. The focus was on their ability to counteract oxidative stress markers and suppress pro-inflammatory responses, which are significant factors in chronic diseases such as diabetes. The researchers analyzed these fruits for their potential incorporation into various products such as pharmaceutical preparations, smart foods, functional beverages, and nutraceuticals. In the discussion of the results, it was emphasized how cherries and blueberries exhibit significant biological potential. They were not only seen as effective in combatting oxidative stress and inflammation but also as potential immune boosters. The conclusions underscored the fruits' potential role as functional foods and their relevance to the burgeoning popularity of functional beverages, hinting at their promise for inclusion in a variety of health-related products.

A Systematic Review published in 2022 in the journal Oxidative Medicine and Cellular Longevity found that Ginger, native to Southeast Asia, possesses antioxidant and antiviral properties, contributing to healthy ageing and potential prevention of age-related disorders. The study explored the natural benefits of ginger, a plant native to Southeast Asia renowned for its culinary and medicinal uses. The approach focused on examining the plant's antioxidant, anti-inflammatory, anticancer, antimicrobial, and particularly antiviral properties from its rich collection of antiviral compounds. The process involved digging into accumulated evidence that suggests ginger's role in promoting healthy ageing, reducing morbidity, and prolonging a healthy lifespan, thus providing a natural solution for an age-old problem. In terms of results, the examination of evidence proved affirming. Ginger displayed significant potential in boosting healthy ageing, reducing the risk of age-related disorders, and extending a wholesome life expectancy due to its inherent properties. The plant's antioxidant characteristics played a key role in these outcomes, along with its anti-inflammatory and antiviral attributes. In essence, the research unfolded a rather underexplored potential of a common natural product in tackling age-induced health conditions.

A Animal Study published in 2022 in the journal Cytokine found that Walnut seed skin extract demonstrates potential hepato-renal protective effects, inhibiting inflammatory responses, oxidative stress and apoptosis, in kidney-damaged Sprague-Dawley rats. In the methodology, Sprague-Dawley rats in acute kidney injury state were divided into three groups: a healthy control, a group induced with renal ischemia/reperfusion (IR), and another group induced with renal IR and treated with walnut seed skin (WSS) extract. Blood, liver and kidney tissues were collected for serum evaluations of aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, urea, and creatinine. Histopathological studies were performed on liver and kidney tissues, and gene markers related to anti-oxidant, anti-inflammatory, and apoptotic effects were measured. The results showed an improvement in deteriorated serum parameters in rats with renal ischemia pre-treated with WSS extract. Histopathological analysis revealed a protective effect of WSS on kidney and liver tissues. Though gene expression studies yielded diverse results for liver and kidney tissues, the consensus was that WSS had a pronounced protective impact on the liver. It was inferred that WSS's healing potential in renal and hepatic tissues seems to work via inhibiting inflammatory response, oxidative stress, and apoptosis.

A Review Article published in 2022 in the journal Phytomedicine found that Ellagic acid, commonly found in various plant foods, can enhance cancer treatment by boosting the effects of chemotherapy and radiotherapy while reducing their side effects. The presented review compiled in vitro and in vivo experimental evidence of the synergistic effect of Ellagic acid (EA) in cancer therapy from multiple databases including PubMed, Web of Science, and Google Scholar. The focus was on the use of EA in conjunction with conservative treatment methods such as chemotherapy and radiotherapy. The results suggest that EA, a polyphenolic compound found in various plant foods, has the potential to enhance the effectiveness of these treatment methods. It was found to improve treatment outcomes when combined with a low dosage of therapeutic drugs or optimized radiation levels. Additionally, EA appears to have a preventative effect against the adverse reactions normally associated with chemotherapy, possibly due to its antioxidant and anti-inflammatory properties. This makes it a promising candidate as a drug adjuvant in cancer treatment.

A Experimental Study published in 2022 in the journal Pak-Euro Journal of Medical and Life Sciences found that Ethanol and n-hexane extracts of Chrysanthemum indicum reveal potent anticancer activity against HepG2 cancer cells by promoting apoptosis and reducing cell proliferation. The research methodology involved extracting compounds from Chrysanthemum indicum using ethanol and n-hexane. These extracts were then applied to HepG2 cancer cells. The study then carefully examined the effect on cell viability and proliferation, as well as indications of apoptosis, in the treated cells compared to untreated control cells. In addition to this, the antioxidative capabilities and antioxidative scavenging activity of the extracts were assessed, particularly focusing on their ability to neutralize nitric oxide, DPHH radicals, H2O2, and superoxide. The results of this process demonstrated that both the ethanol and n-hexane extracts of Chrysanthemum indicum exhibited significant anticancer activity. This was evidenced by a marked decrease in cell viability and proliferation in the treated cancer cells, alongside an increase in indicators of apoptosis. Particularly, the ethanol extract showed more potent anticancer activity and antioxidative capability than the n-hexane extract. The treated cancer cells also showed greater antioxidative scavenging activity, further hinting at the antioxidant potential of these plant extracts.

A Experimental Study published in 2022 in the journal Journal of Food Biochemistry found that Coconut water and coconut milk ameliorate the negative impacts of heat stress on gastrointestinal health by reducing oxidative stress and suppressing inflammatory responses. The study enlisted four different temperature exposure groups of rats, namely a control group at 30 degrees Celsius, a heat-stressed group exposed to an ambiance of 40 degrees, a heat-stressed group pre-treated with coconut water, and a heat-stressed group with coconut milk. Measurements such as skin and rectal temperatures, as well as evaluations of gastrointestinal motility factors such as intestinal transit, intestinal fluid accumulation, and colonic motility, were taken before and after a two-hour heat exposure over 14 days. Noticeable increases in gastrointestinal motility factors were observed amongst the heat-stressed rats. However, the introduction of coconut milk and water appeared to reverse these increases. Furthermore, the elevated cortisol levels and intestinal lipid peroxidation in the heat-stressed rats were significantly reduced with the introduction of both coconut products. Likewise, results showed an increase in antioxidant enzyme activities in the rats that received either coconut water or milk, in contrast to the control group. Similarly, the coconut water and milk were seen to suppress inflammatory cytokines while enhancing others. The study also noted significant improvements in intestinal morphology among heat-stressed rats treated with either coconut product.

A Review Article published in 2022 in the journal Pharmacological Research - Modern Chinese Medicine found that The Jing Si Herbal Drink, composed of various antiviral, antioxidant and anti-inflammatory herbs, has been confirmed as potentially effective in treating COVID-19 symptoms. The methodology incorporated in this study involves analyzing the efficacy of the component herbs present in Jing Si Herbal Drink (JSHD). This was done through in vivo and in vitro testing to understand their potential in treating COVID-19. JSHD comprises a combination of 5 antiviral, 7 antioxidant, 7 anti-inflammatory herbs. Furthermore, it includes 2 herbs that inhibit the overactive immune system, one herb that reduces cell apoptosis, and another with antithrombotic ability. These constituent herbs were evaluated for their impact on the pathogenesis of COVID-19. Discussion of the results showed that the ingredients in JSHD have demonstrated potential effectiveness against COVID-19. The active ingredients in the drink were effective in providing symptomatic relief for infected patients. The antiviral, antioxidant, and anti-inflammatory herbs, along with those altering immune response, inhibiting cellular apoptosis and providing antithrombotic capacity, were all found beneficial against the disease. Thus, JSHD holds promise as a useful adjuvant or supplementary treatment in handling COVID-19.

A Review Article published in 2022 in the journal International Journal of Innovative Research in Engineering & Management found that Carrots, rich in carotenoids, flavonoids, and vitamins, have numerous health benefits including antioxidants, immune enhancement, and anti-cancer properties. The paper provides an insightful review of carrots and their biochemical properties and wide-ranging health benefits. It presents carrots as a tuber crop rich in elements like carotenoids, vitamins, and soluble fiber, which contribute to their wellness properties. The consumption of carrots is increasing owing to their recognized value as a natural source of antioxidants with anti-cancer properties. The review also discusses the various uses of carrots and its by-products, carrot pomace, in food processing to boost the nutritional content of various products. The carrots are used in diverse culinary preparations from salads & curries to nutritionally rich processed goods like juices, dry powder, candy, pickle, and gazrailla. Furthermore, carrot pomace which is abundant in beta-carotene is used to improve products such as bakery goods and also to create a range of useful products.

A Systematic Review published in 2022 in the journal Biomedicine & Pharmacotherapy found that Plums, specifically European and Japanese species, exhibit anti-inflammatory and antioxidant properties that may be used for the treatment and prevention of cancer. Methodology: The researchers conducted a systematic review of existing literature related to the effects of plums on cancer prevention and treatment. They used a variety of databases including Scopus, Google Scholar, PubMed, Medxriv, and the Cochrane Library, considering studies published from the inception of each database till July 2021. The validity of the studies was checked using the CONSORT checklist tool for quality assessment. A total of 6639 studies were initially scrutinized, narrowing down to 54 relevant studies for in-depth review. Discussion of Results: The analysis of the chosen studies revealed high antioxidant content in plum extracts. While the majority of the research supporting these findings were conducted in vitro, a smaller quantity of clinical studies involved in vivo testing. The promising results gathered from these studies suggest the potential of plums being used both for treatment and preventing cancer, especially due to their antioxidative properties.

A Review Article published in 2022 in the journal Graefe's Archive for Clinical and Experimental Ophthalmology found that Curcumin, a spice used in Indian cooking, shows potential therapeutic effects in various retinal diseases, including during the COVID era. The research used PubMed and MEDLINE databases to examine a wide range of studies pertaining to the role of curcumin in various retinal diseases and its use during the COVID era. Specific diseases investigated include diabetic retinopathy, age-related macular degeneration, retinitis pigmentosa, retinal ischemia reperfusion injury, and proliferative vitroretinopathy. In these studies, curcumin's performance was tested in different experimental models, where it demonstrated pleiotropic effects through its action on various cell types like HRPC, HREC and ARPE-19. The research also evaluated the molecule's impact on retinal endothelial cells and its ability to inhibit actions of certain proteins and genes implicated in retinal disease. Moreover, the search also included curcumin's influence in the COVID-19 landscape. Discussing the results, curcumin proved efficacious in retinal disease management by increasing antioxidant enzymes, reducing inflammatory mediators, and inhibiting growth factors. In the context of diabetic retinopathy specifically, curcumin acted by reducing Reactive Oxygen Species (ROS) and inhibiting apoptosis-inducing proteins. Furthermore, curcumin downregulated several inflammatory molecules and hindered retinoblastoma cell proliferation, migration, and apoptosis. In the COVID era, curcumin showcased its potential by inhibiting viral replication and cytokine storm.

A Experimental Study published in 2022 in the journal Journal of Ethnopharmacology found that Saffron petal extract and anthocyanins can alleviate symptoms of Polycystic Ovary Syndrome by rectifying hormonal imbalances and reducing inflammation in PCOS mice. The study conducted experiments on mice induced with Polycystic Ovary Syndrome (PCOS) through the injection of testosterone enanthate. These mice were then treated with saffron petal extract and anthocyanins to observe the effect on their ovarian hormones, steroidogenic enzymes, ovarian dysfunction, regulation of anti-inflammatory genes, and antioxidant factors. The treatment was found to decrease the elevated levels of luteinizing hormone, testosterone, and estrogen in the PCOS mice, while reviving the reduced follicular-stimulating hormone and progesterone levels. In discussion of the results, it was observed that saffron petal extract and anthocyanins positively altered the levels of gonadotropin receptors, steroid receptors, inflammatory markers, inflammatory-related factors, and antioxidant enzymes that were affected by the PCOS condition in the subject mice. The study also noted that the reproductive tissues of the PCOS mice, which were converted into androgen-dominant environments by the testosterone enanthate induction, were restored into estrogenic conditions after the treatment. Further findings suggested that saffron petal extract and anthocyanins led to amelioration of PCOS symptoms by enhancing the regulation of ovarian steroids, steroidogenic processes, antioxidant enzyme production, and inflammatory markers.

A Review Article published in 2022 in the journal South African Journal of Botany found that Chrysanthemums, popular floricultural crops, not only hold significant ornamental value but also exhibit various therapeutic potentials including antioxidant, antimicrobial, and anticancer activities. The method involved in this research aimed at studying the genus Chrysanthemum through a decade-long review (2010-2020) of scientific evidence, focusing on its therapeutic potential, phytochemistry, and pharmacological activities. Various phytochemical compounds including flavonoids, terpenoids, polysaccharides, and unsaturated fatty acids, which are present in the genus Chrysanthemum, were identified. In addition, the taxonomy, distribution, horticultural, and traditional uses of the genus were also studied. The results demonstrated that Chrysanthemum species show numerous potential medicinal benefits, ranging from antioxidant to antimicrobial, anti-inflammatory, anticancer, anti-allergic, anti-obesity, immune regulation, hepatoprotective and nephroprotective activities. The research also underlined the opportunity of medicinal exploitation of the genus Chrysanthemum, given the extreme popularity of these plants and the wide range of phytochemical compounds they contain. The ornamental, medicinal, environmental, and industrial values of these plants further establish them as leading floricultural crops.

A Review Article published in 2022 in the journal Reference Series in Phytochemistry found that Coconut water possesses unique compound profiles that imbue it with a broad spectrum of medical properties, incorporating aspects of nutrition, pharmacology, and disease prevention. The study utilized comprehensive analysis to assess the chemical profile of coconut water, identifying a range of components including phytohormones, enzymes, antioxidant compounds, vitamins, minerals, and phenolic compounds. These components are known to contribute to the water's biological activity and pharmacological effects, thereby enabling a raft of medicinal properties inherent to coconut water. The water was found to feature anti-microbial, anti-bacterial, anti-inflammatory, anti-hypertensive, rejuvenating, hepatoprotective, hypolipidemic, and diuretic properties. An examination of the therapeutic effects of coconut water revealed a significant impact on gastric dysfunction, dysentery, and child malnutrition alongside notable capabilities to manage hypertension. The water was found to promote exercise performance, reduce swelling, dissolve kidney stones, improve kidney function, improve digestion, relieve constipation, reduce the risk of heart disease, lower high blood pressure, and improve cholesterol levels. Consumption of tender coconut water was specifically found to reduce the risk of heart disease, help prevent Alzheimer’s disease pathologies and prevent osteoporosis in experimental animals. The unique nutritional profile of coconut water was also found to provide it with the capacity to balance body chemistry and fight cancer.

A Theoretical Article published in 2022 in the journal Traditional Medicine Research found that The jujube tree bears fruit endowed with substantial nutritional value and contains numerous phytochemical components with reported antioxidant, anti-cancer and neuroprotective properties. The research implemented an analysis of the jujube tree, its fruit, and its long history of usage in traditional medicine, focusing primarily on its use in traditional Persian and Chinese medicines. The varied geographical distribution of the tree was studied, especially its presence in tropical and subtropical regions across Europe and Asia. Researchers took into account the tree’s resilience to soil salinity and alkalinity as part of its general characteristics. The core of the study involved an in-depth investigation into the nutritional composition and pharmacological properties of the jujube fruit. The fruit's contents were categorized into proteins, minerals, vitamins, organic acids, and carbohydrates. Furthermore, a range of phytochemical components such as polyphenols, flavonoids, terpenoids, anthocyanins, alkaloids, and carotenoids were identified. Research noted both the fruit's nutraceutical and cosmeceutical potential. It also explored the medicinal properties of all elements of the plant, not just the fruit. The physiological impacts of the jujube were also evaluated across various medical contexts, seeking to understand its impact on different organs and tissues, as well as its influence on various health conditions and concerns. Culminating in the identification of antioxidant, anti-cancer, antimicrobial, neuroprotective, cardioprotective, hepatoprotective properties. Noteworthy, are also its health-promoting effects, with strong references to anti-aging properties.

A Review Article published in 2021 in the journal Current Drug Delivery found that Pomegranate juice and its bioactive components may serve as cost-effective, next-generation non-pharmacologic anticancer therapies, particularly against colorectal and prostate cancer. Methodology: The present review was undertaken to provide current information on the impact of pomegranate juice and its bioactive elements, critically focusing on the effects on the most common six types of cancer. The inherent polyphenolic compounds of pomegranate, such as ellagitannins and punicalagin, are known to have substantial antioxidant capability which has been evaluated through in vitro and in vivo studies. These compounds' ability to avert free radicals and design metal-chelates in biological tissues have offered a useful basis to extrapolate their impact on various types of cancers. Discussion of Results: The findings indicate that the antioxidant and anti-inflammatory properties of pomegranate possess significant antimutagenic and antiproliferative activities, which proved to be beneficial in modifying gene expression, moderating cellular mechanisms, and limiting the metastasis of cancerous cells. In addition to this, there are reports from a few clinical trials showing the potential of pomegranate ingredients to prevent and treat cancer, notably colorectal and prostate cancer. It’s been noticed that the pomegranate driven therapies may prove to be a cost-effective alternative to costly chemotherapies which often carry drug resistances and severe side effects. Such therapies could offer lesser side effects, making them potential candidates for future non-pharmacologic anticancer treatments.

A Experimental Study published in 2021 in the journal Molecular & Cellular Toxicology found that Cocoa bean husk, a by-product of cocoa processing, exhibits potent antioxidant and anticancer effects on prostate cancer cells due to its high phenolic compound content. The methodology of the study involved fractionating ethanol crude extract of cocoa bean husk (CBH) and comparing the total polyphenol and flavonoid content, as well as radical scavenging activities, of the various fractions. The phenolic compounds present in the ethanol ethyl acetate (EAF) and butanol (BF) fractions were further analysed using High-Performance Liquid Chromatography (HPLC). These fractions were then applied to prostate cancer cell lines PC3 and DU145 to ascertain their impact. The results indicated that the ethyl acetate fraction exhibited the highest phytochemical content and antioxidant activity, closely followed by the butanol fraction. The presence of abundant phenolic compounds, namely catechin, epicatechin, and procyanidin B, was observed in both fractions. Moreover, both fractions induced apoptosis and DNA fragmentation in the prostate cancer cells in a concentration-dependant manner, demonstrating their potential anticancer effects.

A Systematic Review published in 2021 in the journal Future Pharmacology found that Eating kiwifruits improves bowel movements and decreases stool consistency, also providing anti-inflammatory and antioxidant benefits to the gut barrier. The review included nine clinical studies investigating the effect of kiwifruit consumption on intestinal function and constipation. The studies, focusing on young or middle-aged adults predominantly, required participants to consume between two to four kiwifruits daily for durations varying from three days to four weeks. The impact on elderly individuals was less explored. The review indicates that kiwifruits can enhance bowel movements and reduce stool consistency in both healthy individuals and those suffering from irritable bowel syndrome-induced constipation. The fiber and water content of kiwifruits is thought to contribute to these results. Furthermore, consumption of kiwifruit showed extra intestinal health advantages, including anti-inflammatory and antioxidant effects on the gut barrier. However, when focusing on patients with constipation, the fruit's consumption correlated with a temporary increase in defecation frequency but inconsistently impacted stool consistency. High-quality methodical studies and meta-analysis substantiated these findings.

A Systematic Review published in 2021 in the journal Antioxidants found that Green tea supplementation improves total antioxidant capacity and impacts oxidative stress based on dose levels in adults. The research's methodology involved a systematic search of research materials published in English language up to 21 August 2021. Recognized online databases such as Scopus, PubMed, Embase, and ISI Web of Science were utilized with the appropriate keywords. The study focused on randomized controlled trials that evaluated green tea supplementation, and its relationship with malondialdehyde and total antioxidant capacity in adults. A random-effects model quantified the difference, and the researchers carried out meta-regression and non-linear dose-response analyses to investigate the association between the quantity of green tea consumed and the duration of the intervention. The research analysed the results obtained from sixteen randomized controlled trials, which amount to seventeen study arms comprising a total of 760 participants. The study found that green tea supplementation did have significant effects on total antioxidant capacity, and these effects were chiefly linked to gender and body mass index. However, the results showed that these effects were not significant in cases of low-dose supplementation and obese individuals. On the other hand, no relationship was found between malondialdehyde and green tea supplementation in any subgroup. Nonetheless, meta-regression analyses indicated an inverse linear connection between the change in MDA and the dosage of green tea.

A Review Article published in 2021 in the journal Critical Reviews in Food Science and Nutrition found that Green tea and its component EGCG, demonstrate potential as a treatment for endometriosis by inhibiting growth, invasion, adhesion and angiogenesis. The main research methodology of this work is a narrative review. The paper comprehensively collects and reviews various preclinical studies that propose the use of green tea as a potential treatment for endometriosis. These studies explore the diverse biological properties and activities of green tea and its major bioactive component, (-)-epigallocatechin gallate, including anti-angiogenic, anti-proliferation, anti-metastasis, and apoptosis induction functions. Different potential mechanisms used by green tea to inhibit the growth of endometriosis are considered, such as its effects on inflammation, oxidative stress, invasion, adhesion, and apoptosis. The discussion of the reviewed data highlights the potential therapeutic effects of green tea acting on different molecular and cellular mechanisms in endometriosis. The researchers keenly discussed how green tea exhibited an inhibitory effect on the disease through multiple avenues, including reducing inflammation and oxidative stress, preventing tumor invasion and adhesion, promoting apoptosis (cell death), and limiting angiogenesis (the development of new blood vessels) - all these factors contribute to the growth and progression of endometriosis. The discussion elaborates on the significant roles and wider implications of these processes in understanding and potentially treating endometriosis.

A Review Article published in 2021 in the journal Journal of the Science of Food and Agriculture found that Curcumin, derived from turmeric, exhibits an extensive range of biological and medicinal properties, including anti-inflammatory, antioxidant, and antifungal qualities. The research examines turmeric extracts, specifically focusing on curcumin, a yellow biocomponent. An array of its medicinal and biological properties is explored, particularly anti-inflammatory, antioxidant, and antifungal attributes. Traditionally used in various cultures for a range of health issues like inflammation, cough, wounds, liver disorders, and cancers, curcumin's extensive application in treating a variety of diseases potentially positions it as a significant component in modern medicine. The study also notes the successful tolerance of curcumin at high doses with no adverse effects. The analysis extends to the preferred methods for the encapsulation of curcumin, detailing techniques such as nanocomplexing, gelation, complex coacervation, electrospraying, and solvent-free pH-driven encapsulation. These methods have demonstrated effectiveness in encapsulating curcuminoids. Moreover, the chemical traits of curcumin are also highlighted, providing a basis for further potential applications in the development of health-promoting functional products.

A Experimental Study published in 2021 in the journal Chemistry & Biodiversity found that Chrysanthemum, a traditional Chinese medicine, shows significant antioxidant activity and hepatoprotective effects, making it a potential resource for functional foods and medicinal materials. A comprehensive evaluation of 25 common chrysanthemum varieties in China was carried out for their chemical constituents, antioxidant activity, and hepatoprotective effects. Initially, the water extracts from chrysanthemums were analysed using liquid chromatography-mass spectrometry and 29 chemical components were identified. It was observed that chrysanthemums were rich in chemical constituents with significant differences in the contents of phenolic acids and flavonoids among the varieties. Afterwards, the antioxidant activities of different chrysanthemums were investigated through different assays. The relationships between nine main components and antioxidant activities were examined to identify the antioxidant constitutes in chrysanthemums. The study also examined the capacity for each cultivar to protect against cell damage, with certain cultivars standing out with higher efficacy. The hepatoprotective effects of eight mainstream varieties were determined using a model of acute alcoholic liver injury. The chrysanthemums were found to protect the liver from injury by impacting relevant liver function and antioxidant indexes. Selected varieties could decrease certain liver activities, while others significantly decreased harmful content in liver tissue, showing significant antioxidant capacity.

A Systematic Review published in 2021 in the journal Veterinary Medicine and Science found that Ginger significantly improves sperm health, enhancing quality parameters like count, viability, motility, morphology and DNA integrity, thereby boosting fertility. The study investigated the impact of ginger on semen quality across different species. It focused on key sperm parameters including count, viability, motility, morphology, and DNA integrity. The research pointed to the antioxidant properties of ginger, attributed to active phenolic compounds, which disrupt the production of free radicals - these are known to cause oxidative stress and negatively impact the quality of sperm. The study also noted ginger's androgenic activity and the associated influence on the levels of gonadotropin and sex hormones, such as testosterone. In the discussion of results, it was identified that ginger minimizes DNA failures, reduces damage to the mitochondrial genome in sperm cells, and essentially moulds a sperm with apt morphological structure. The sperm, under the influence of ginger, attains progressive motility, high viability, and increased fertility. Overall, the entire fertility indicators of sperm also saw an upswing with the usage of ginger - reinforcing its effectiveness in increasing the total motility, survival rate, the normal morphological structure of sperm, and the number of sperm cells.

A Review Article published in 2021 in the journal Metabolites found that The date palm enhances both male and female fertility parameters through its nutritional attributes and antioxidant functionality. The research conducted a thorough review of the role of date palm in treating infertility. The health benefits of date palm and its varied components were explored, with a focus on their effects on reproductive parameters in both sexes. The comprehensive review shed light on how the substantial nutrients and antioxidant features of date palm can be beneficial for people dealing with infertility. In men, the study found direct links between consumption of date palm and improved hormonal levels alongside notable enhancements in seminal vesicle parameters and sperm quality. For women, this natural remedy showed a positive impact on the process of oogenesis, hormone regulation, and improving pregnancy outcomes. The focus was on the potential of date fruit as a natural enhancer of fertility, downplaying the role of any synthetic or invasive medical interventions. The study thus testifies to the innovative use of a widely available natural resource in addressing a pressing health issue.

A Review Article published in 2021 in the journal Clinical Ophthalmology found that Curcumin, with its anti-inflammatory, antioxidant, antimicrobial and antimutagenic properties, is a potential therapeutic agent for retinal diseases. This review paper uses various pieces of research from the literature to detail the characteristics of curcumin, a molecule produced by plants. The paper particularly focuses on the beneficial and controversial aspects of curcumin. It talks about the retina's susceptibility to oxidative stress due to its cell composition and constant exposure to photons, highlighting that retinal ganglion cells and photoreceptors are particularly sensitive to oxidative damage. The paper also points to studies that link an imbalance in reactive oxygen species to a wide range of retinal diseases. In the discussion of results, it is stated that a number of studies suggest that curcumin can be well tolerated by humans when taken orally and does not tend to have negative effects, making it a promising candidate for retinal disease treatment. However, a primary limitation is curcumin's poor bioavailability; the body can only absorb a small fraction of the substance as an active compound. Despite that, efforts have been made to improve curcumin's accessibility to target tissues in sufficient quantities.

A Clinical Study published in 2021 in the journal Journal of Herbal Medicine found that Green tea therapy can significantly improve rheumatoid arthritis symptoms, correlating with changes in specific circulating serum molecules, miR-125b and miR-146a. In this study, 100 female patients suffering from rheumatoid arthritis and 50 healthy female subjects were examined. Patients with rheumatoid arthritis underwent green tea therapy, where they consumed 5 cups of green tea daily, delivering a total of 1230 mg of catechins, over a span of 24 weeks. During this time, researchers used real-time PCR analysis to measure the levels of miR-146a and miR-125 b in the patients' peripheral blood mononuclear cells. These cells were isolated from the subjects at three distinct stages: the starting point (baseline), after 12 weeks, and finally after 24 weeks of the treatment. The observations revealed a notable increase in the level of circulating miR-125 b and decrease in miR-146 expression, and these shifts were seen to correspond positively with measures of disease activity and pain intensity in the patients after 24 weeks of the green tea therapy. Also of note was that the levels of miR-146a and miR-125b could accurately predict the clinical response to green tea therapy in 65% of the rheumatoid arthritis patients. Discrepancies in miR-146a and miR-125b levels following green tea therapy suggests that they may be attributed to the joint protective, antioxidant, and anti-inflammatory effects of green tea. It was therefore proposed that both miR-146a and miR-125b could potentially serve as diagnostic, therapeutic, and predictive biomarkers in green tea therapy and may even have valuable application in related non-drug rheumatoid arthritis therapy.

A Review Article published in 2021 in the journal Applied Sciences found that There is a notable gap in scientific research on the potential health benefits and antioxidant activity of matcha tea compared to green tea. The strategy used in this study was a literature review that critically evaluated existing research publications on both green tea and matcha tea. This focused primarily on the concentration and potential benefits of their bioactive components and polyphenols. Key areas of comparison included antioxidant activity and potential health benefits in each tea variety. The comparison was made simultaneously considering the scarcity of studies specifically focused on matcha tea. The discussion of the results became apparent that there is a significant discrepancy in the volume of scientific literature available on green tea compared to that on matcha. Despite matcha tea being rich in bioactive components and polyphenols, the lack of research has left its potential health benefits and antioxidant activity largely unexplored. This discrepancy emphasizes the immediate need to address the gap between public usage and awareness of matcha tea's benefits with scientific approval and understanding.

A Systematic Review published in 2021 in the journal medRxiv found that The available evidence provides a good indication that nut consumption can result in a small improvement in blood pressure in adults. A total of 31 RCTs with 2784 participants were included. Each 20 g/d increase in nut consumption reduced systolic blood pressure and diastolic blood pressure. The effect of nuts on systolic blood pressure was more evident in patients with type 2 diabetes. The results were robust in the subgroup of trials with low risk of bias. Levels of systolic blood pressure decreased proportionally with the increase in nuts consumption up to 40 g/d, and then appeared to plateau with a slight upward curve. A linear dose-dependent reduction was seen for diastolic blood pressure, with the greatest reduction at 80 g/d. The available evidence provides a good indication that nut consumption can result in a small improvement in blood pressure in adults. Well-designed trials are needed to confirm the findings in long term follow-up.

A Randomised Controlled Trial published in 2021 in the journal Advances in Integrative Medicine found that Pomegranate peel extract supplementation can decrease total cholesterol and triglyceride levels while boosting antioxidant status in obese women with knee osteoarthritis. The research was a randomized, double-blind placebo-controlled trial involving 66 obese women aged 38 to 60 years old with knee osteoarthritis. These participants were split into two groups, the intervention group and control group, each containing 33 members. The intervention group received pomegranate peel extract capsules (500 mg) twice daily for 8 weeks including standard drug therapy while the control group was given a placebo during the same period. All participants' fasting blood samples, anthropometric measurements, dietary intake data, and physical activity levels were collected both before the start and at the end of the trial. Results analysis showed that pomegranate peel extract supplementation brought down levels of serum total cholesterol, triglyceride and an oxidative stress marker while enhancing levels of some antioxidant enzymes and the overall antioxidant capacity when compared to the control group. However, there were no noticeable alterations between the two groups in terms of low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and body mass index by the end of the experiment.

A Review Article published in 2021 in the journal Journal of Ethnopharmacology found that Pomegranate has a variety of phytochemicals which possess wide-ranging activities including antioxidant, antimicrobial, anti-oncogenic properties, and resistance to cerebrovascular disease. The paper presents an overview of the traditional medicine theories of pomegranate, its origin and spread along the Silk Road, ethnopharmacological uses, chemical compositions, pharmacological activities, toxicology, and the involved pathways. Information was collected from various published sources like ancient and modern texts, medicinal plant monographs, pharmacopoeias and diverse electronic databases. Pomegranates, being widely cultivated in Central Asia and having spread throughout China via the Silk Road, have had significant usage in many traditional medical systems over time. They are identified to contain a vast array of phytochemicals like tannins, organic acids, flavonoids, alkaloids, and volatile oils. These compounds are observed to have extensive activities such as antioxidant, antimicrobial and anti-oncogenic properties, and also provide resistance to cerebrovascular disease. The research additionally presents a summary of the promising pharmacological pathways linked with pomegranate.

A Randomised Controlled Trial published in 2021 in the journal Journal of Complementary and Integrative Medicine found that Avocado/soy unsaponifiables effectively treat osteoarthritis by controlling the balance between oxidant and antioxidant molecular markers. The methodology used in this study was a double-blind, randomized, placebo-controlled, cross-over trial. Forty osteoarthritis patients were classified into two groups: one received avocado/soy unsaponifiables (ASU) for three months followed by three months of placebo, and the other group received a placebo first for three months followed by three months of ASU. The patients' oxidant status was evaluated by measuring their serum malonldialdehyde (MDA). Other measures such as total antioxidant capacity, reduced glutathione, and antioxidant enzymes like superoxide dismutase and catalase were also assessed. After three months of treatment, all patients who were given avocado/soy unsaponifiables exhibited a significant decrease in their serum MDA levels, indicating lower oxidative stress. In comparison, these levels were higher at baseline and after placebo treatment. Furthermore, the treatment with avocado/soy unsaponifiables resulted in positive changes in the patients' antioxidant levels. Analysis also showed that the effect of avocado/soy unsaponifiables was consistent, regardless of the sequence in which the medication was received. These findings demonstrate that avocado/soy unsaponifiables can contribute effectively to the treatment of osteoarthritis by regulating the balance between oxidant and antioxidant molecular markers.

A Review Article published in 2021 in the journal Journal of Food Biochemistry found that Pomegranate demonstrates anti-proliferative, anti-oxidant, anti-inflammatory properties that can effectively control the progression of various respiratory diseases. The research methodology involved both in vivo and in vitro studies to examine the potential effects of pomegranate fruit, juice, extract, peel powder, and oil on a variety of respiratory disorders such as asthma, lung cancer, and chronic obstructive pulmonary disease. The focus was to understand the properties of pomegranates that led to its anti-proliferative, anti-oxidant, anti-microbial, anti-inflammatory, anti-cancer, and anti-tumorigenic effects, and how these qualities could potentially attenuate these diseases through modulation of various signaling pathways. The discussion of results revealed that pomegranate was effective in controlling the progression of diverse respiratory diseases, suggesting it could be a key therapeutic target. These results not only demonstrated the potential medical benefits of pomegranate against lung-based diseases but also highlighted its possible role in influencing the lung fibrinolytic system. The findings from both preclinical and clinical studies underscored the influence of pomegranate in tackling lung diseases.

A Review Article published in 2021 in the journal Evidence-Based Complementary and Alternative Medicine found that The fresh rhizoma of Roscoe, a traditional Chinese medicine, has proven effects on the nervous and cardiovascular systems and has antibacterial, antitumor, and antioxidant properties. The methodology for this comprehensive review encompased the exploration of the botany, ethnopharmacology, phytochemistry, pharmacology, and toxicology of Zingiberis Rhizoma Recens. This involved studying over 100 chemical compounds found in the fresh rhizoma of Roscoe, including gingerols, essential oils, and diarylheptanoids among others. Various modern scientific methods and principles were employed in order to establish a broad understanding of the medicinal properties and potential applications of the herb. The results of the review demonstrated the multitudinous health benefits of Zingiberis Rhizoma Recens. In particular, it has thoroughly documented pharmacological effects on the nervous and cardiovascular systems. Moreover, it has been shown to have antiemetic, antibacterial, antitumor, anti-inflammatory, and antioxidant effects. The study reinforced the wide usage of the herb in traditional Chinese medicine and underscored the versatility of its applications. However, it also revealed disparities in the evaluation standards of the herb's quality and clinical efficacy.

A Experimental Study published in 2021 in the journal Antioxidants found that Pomegranate juice extract (PPJE) appears to reduce chemotherapy-induced skin side effects by inhibiting inflammation and promoting wound repair on the skin. In this study, the impact of pomegranate (L.) juice extract (PPJE) on skin cells treated with 5-Fluorouracil (5-FU), an antineoplastic agent, was evaluated. This involved assessing the extract's ability to inhibit the release of reactive oxygen species and enhance the cellular antioxidant response of the treated skin cells. Specific attention was given to observe the overexpression of cytoprotective enzymes such as heme oxygenase-1 and NAD(P)H dehydrogenase [quinone] 1 after the introduction of PPJE. The results indicated that PPJE indeed blocked the formation of nitrotyrosine and reduced the release of cytokines, therefore indicating a dampened inflammatory response. Furthermore, it was revealed that the extract could inhibit the nuclear translocation of p65-NF-κB, a key regulator of inflammation. The study also pointed out that PPJE could curb apoptosis in cells treated with 5-FU, whilst fostering wound repair. The overall findings suggest that PPJE holds potential as a supplementary agent for managing oxidative and inflammatory issues associated with chemotherapy-induced skin side effects.

A Review Article published in 2021 in the journal Molecules found that Green tea, coffee, wine, and curry have beneficial health effects due to the polyphenols they contain, which possess both antioxidant and pro-oxidant properties. The research leverages epidemiological studies, clinical trials, cell-based studies and animal tests to examine the effects of green tea, coffee, wine, and curry -- and their key polyphenols -- on human health. The polyphenols investigated include epigallocatechin gallate in green tea, chlorogenic acid in coffee, resveratrol in wine, and curcumin in curry. The study concentrates on the workings of these polyphenols, primarily focusing on reactive oxygen species (ROS), and how they perform both anti- and pro-oxidant functions, fundamentally influencing different enzymes and factors with health contributions. In the discussion of the results, it is mentioned that the anti-oxidative actions of these polyphenols assist in the scavenging of ROS and the downregulation of the nuclear factor-κB, yielding beneficial anti-inflammatory effects. Conversely, their pro-oxidant actions appear to elevate ROS production, encouraging the activation of 5'-AMP-activated protein kinase that regulates different enzymes and factors for health improvement. However, the exact mechanism of how these polyphenols exhibit either pro- or anti-oxidant effects remains unclear. Also, the research underscores that while many studies note their health benefits, some others show no positive effects on health conditions such as obesity, suggesting that outcomes could be influenced by various study factors.

A Review Article published in 2021 in the journal International Review of Neurobiology found that Goji berries have significant potential as a natural medicine in anticancer efforts due to their high content of active compounds. The research involved extraction and analysis of various fractions from goji berries to ascertain their impact on different types of cancer. These fractions included polysaccharides, polyphenols, flavonoids, carotenoids and their derivatives, and they were tested against particular types of cancer cells, such as those of breast carcinoma. The effect of these extracts on normal human cells, however, has not been explored. Two distinct stages were mapped out: one with a pectin-free fraction of goji berry extract used to inhibit the growth of two breast cancer cell types, and another phase involving an ethanol extract inhibiting a different breast cancer cell line. In the discussion of results, the study revealed that various extracts from goji berries exhibit antiproliferative properties against different types of cancer cells. Evidence shows that a certain pectin-free fraction of the goji extract inhibited the growth of specific types of breast cancer cells, while an ethanol extract curtailed the proliferation of another type in a time- and dose-dependent manner. The study also found that goji polysaccharides not only influence estrogen metabolism but also activate certain cellular signaling pathways and increase the expression of a certain protein.

A Review Article published in 2021 in the journal SSRN Electronic Journal found that Phytochemicals in carrots, particularly carotenoids, are effective at reducing eyesight degeneration and treating chronic eye defects due to their antioxidant and anti-inflammatory properties. Throughout the review process, seventy original research and review articles were examined, all published between 2000 and 2020 across four major journal databases: Elsevier, PubMed, ResearchGate and Plos One. The focus of the search was directed by six keywords, centring on both in-vivo and in-vitro study results related to the topic of interest. Among the various findings, it was consistently revealed that carrots contain a multitude of bioactive compounds, notably carotenoids, which have been proven to be effective in halting and treating eye degenerations including Nyctalopia, Myopia, Cataracts, Age-related Macular Diseases and Glaucoma. Carotenoids have been found to work as potent antioxidants and anti-inflammatory agents, defending eyes against vision loss due to oxidative stress. Thus, the increased consumption of carrots can potentially serve as a natural therapeutic approach and enhancer of vision.

A Experimental Study published in 2021 in the journal Food & Function found that The Lycium ruthenicum Murr variety of goji berry exhibits a stronger antioxidant activity and antiproliferative effect on cancer cells compared to Lycium barbarum L. For methodology, the researchers examined the phytochemical profiles of two different varieties of goji berries: Lycium ruthenicum Murr (LRM) and Lycium barbarum L. (LB). They then evaluated the antioxidant activity of these varieties using multiple assays. For the assessments of antiproliferative effect, they tested the ability of high dose LRM and LB supplementation to interfere with cell cycle progression and induce apoptosis in MDA cells, a specific type of cancer cells. In the discussion of results, it was found that LRM overpowered LB in both antioxidant activity and antiproliferative mechanism, owing to its higher total phenolics and flavonoids. LB, while it was higher in VE and carotenoids, had less remarkable effects on cell cycle interference and apoptosis induction. Both LRM and LB triggered the activation of a proliferation-related signaling pathway; however, LB did not manage to lower the levels of two specific proteins which indicates a weaker antiproliferative effect. Despite these differences, both varieties were considered potential assets for managing the growth of cancerous cells and enhancing human health.

A Review Article published in 2020 in the journal Nutrients found that Coffee's bioactive compounds may exhibit various health benefits such as antioxidant and anti-inflammatory properties on the digestive tract and stimulating effects on motor function. The methodology involved a narrative review of the impact of coffee; its by-products; and its bioactive components on the gastrointestinal system and the brain-gut axis. The gastrointestinal mucosa's reactions, mainly involving permeability, secretion, and proliferation, the neural and non-neural elements of the gut wall contributing to its motor function, and the brain-gut connection were all elements of critique and consideration. The results from the in vitro, in vivo, and epidemiological studies demonstrated that coffee induces various effects on the digestive system. For instance, it might act as an antioxidant, have anti-inflammatory effects, and act against cell overgrowth in the mucosa. In addition, coffee seems to promote motor functions in the gastrointestinal tract's external muscle layers. Nonetheless, despite these affirmed possible effects, much about coffee's accurate and detailed influence remains largely unexplored.

A Review Article published in 2020 in the journal Molecules found that Shaded gardening of Japanese matcha creates high-quality tea with unique compounds that can boost physical and mental health. This study reviewed and compiled health benefits of matcha tea, a type of powdered green tea grown traditionally in Japan with plants shaded during growth. This shading process promotes the synthesis and accumulation of unique biologically active compounds, which includes theanine, caffeine, chlorophyll, and a variety of catechins, with matcha offering a condensed source of these elements. The review indicated that matcha is considered the highest quality tea due to its distinctive chemical composition and prized flavor. In discussing the results, a major conclusion reached was that matcha tea has effective health-promoting attributes due to the tea's high content of antioxidant and anti-inflammatory substances. Such benefits have largely been credited to its significant proportion of catechins - a type of phenolic compound beneficial to human health. The high antioxidant potential of the tea and its subsequent ability to help prevent various diseases and support cognitive function underscores the value in regular consumption of matcha for not only physical health, but also mental health.

A Review Article published in 2020 in the journal Journal of Functional Foods found that Jujube fruits contain a high amount of various bioactive compounds exerting antioxidant, anti-inflammatory, antiobesity, anti-cardiovascular disease, hepatoprotective, antidiabetic, anti-microbial, anticancer, and gastrointestinal-protective effects. The scientific evidence has shown that jujube fruits contain a high amount of various bioactive compounds, including ascorbic acid, triterpenic acids, phenolic acids, amino acids, saponins, cerebrosides, flavonoids, polysaccharides, and mineral constituents. These phytoconstituents play important roles to suppress different diseases, exerting the antioxidant, anti-inflammatory, antiobesity, anti-cardiovascular disease, hepatoprotective, antidiabetic, anti-microbial, anticancer, and gastrointestinal-protective effects.

A Experimental Study published in 2020 in the journal Experimental Eye Research found that Gypenosides, the main functional component from the vine Gynostemma pentaphyllum, display potential as a treatment for Retinitis Pigmentosa by protecting photoreceptor cells from degeneration. In this study, researchers used zebrafish carrying a specific mutation that leads to early retinal degeneration like in Retinitis Pigmentosa, a group of genetic retinal disorders. The mutation, present in the retinitis pigmentosa GTPase regulator interacting protein 1 gene, was exposed to Gypenosides. The substance was sourced from Gynostemma pentaphyllum, a climbing vine, and previously found to combat oxidative stress and inflammation in optic neuritis cells. The results suggest significant benefits from the application of Gypenosides to retinitis pigmentosa. Treatment of the mutated zebrafish resulted in a notable decrease in the death rate of photoreceptor cells. The reaction of antioxidant genes typically associated with oxidative stress was also significantly reduced. Furthermore, there were marked reductions in reactive oxygen species and malondialdehyde production, along with diminished expression of pro-inflammatory cytokines. Overall, the outcome indicates that Gypenosides effectively counteracted the harmful effects of the mutation, protecting the photoreceptors from degeneration.

A Review Article published in 2020 in the journal Scientific African found that Pumpkin seeds carry bioactive compounds with potential benefits such as antidiabetic, antidepressant, antioxidant, antitumor, and cytoprotective activities, also aiding in microbiological infections and specific organ disorders. The methodology utilised an in-depth literature review, compiling evidence-based data from various electronic databases such as ScienceDirect, ResearchGate, PubMed, Scopus and Google Scholar up until January 2020. The focus of the gathered literature was the potential use of pumpkin seeds as a functional food ingredient and assessing the associated biological mechanisms of the bioactive compounds within the seeds. Pumpkin seeds, despite being small, are rich in a wide variety of beneficial nutrients such as amino acids, phytosterols, unsaturated fatty acids, phenolic compounds, tocopherols, cucurbitacins and valuable minerals. The bioactive compounds found within these seeds have shown multiple promising activities. They possess anthelmintic, antidiabetic, antidepressant, antioxidant, antitumor and cytoprotective properties. Additionally, they demonstrate potentials for addressing microbiological infections and specific disorders related to liver and prostate. The compiled literature strongly suggests that pumpkin seeds can be used as both a traditional and functional food ingredient due to the wide array of health benefits they offer.

A Systematic Review published in 2020 in the journal Complementary Therapies in Medicine found that Cinnamon supplementation significantly decreases inflammation and oxidative stress levels, serving as a potential additive for cardiometabolic health improvement. The systematic review and meta-analysis followed the Preferred Reporting Items of Systematic Reviews and Meta-Analysis guidelines. A comprehensive search for appropriate clinical trials was performed across multiple databases including PubMed/MEDLINE, Scopus, Cochrane Library, Web of Science, Embase, and Google Scholar until January 2020. After duplicates were removed, 1145 studies were found eligible and 12 studies were finally included in the meta-analysis, investigating the impact of cinnamon supplementation dosages ranging between 1.5 to 4 grams per day. The results of the meta-analysis revealed that cinnamon supplementation led to a significant reduction in inflammation markers, C-reactive protein and interleukin-6, alongside a decrease in malondialdehyde, an oxidative stress marker. Concurrently, an increase was observed in the total antioxidant capacity following the supplementation, implying an enhancement in the body's defensive ability against oxidative damage. Nevertheless, no significant change was identified in the levels of intercellular adhesion molecule-1 after the cinnamon supplementation.

A Review Article published in 2020 in the journal Longhua Chinese Medicine found that Green tea and its compounds, especially catechins, may potentially prevent and treat osteoarthritis due to their potent antioxidant and anti-inflammatory properties. The researchers performed an extensive review exploring the potential impact of green tea and its bioactive compounds, chiefly catechins, on osteoarthritis management. Their focus was on the anti-inflammatory and antioxidant abilities of these compounds. Based on the review, such compounds can quell inflammation by blocking various signaling pathways interconnected with inflammatory processes. Specifically, they have the potential to suppress the expression of several cytokines and enzymes related to inflammation. In addition, green tea was noted for its property to neutralize free radicals, thus averting the formation of harmful reactive oxygen species and countering oxidative stress. While many conventional, non-surgical osteoarthritis therapies can lead to numerous adverse effects, the current review suggests that green tea could serve as a safer alternative. It may be a promising direction in the prevention and management of this chronic, painful, and inflammatory condition, which touches a significant number of people globally.

A Review Article published in 2020 in the journal Molecules found that Green tea polyphenols can potentially protect against neurodegenerative disorders like Parkinson's Disease through antioxidant, anti-inflammatory, and neuroprotective actions. The study synthesized existing research on the potential neuroprotective benefits of green tea polyphenols, particularly in Parkinson's disease. The papers highlighted were drawn from numerous sources and focused on the antioxidant, anti-inflammatory, and neuroprotective attributes of these compounds. Green tea's potential protection against free radicals, inflammation, and neuro-damage were considerable points of interest. The analysis also took into account the complex physiological, social, and cultural factors that could influence the effectiveness of green tea polyphenols in human subjects. Through the evaluation of numerous in vivo studies, researchers came to intriguing conclusions about the overall mechanism of green tea. The studies assessed explored how green tea consumption could mitigate neurodegenerative disorders like Parkinson's. In these analyses, investigators refined their understanding of how green tea and its polyphenols function from a neuroprotective standpoint. This information helps us better understand the advantages of green tea consumption and its potential role in preventing neurodegeneration.

A Review Article published in 2020 in the journal The Journal of Nutritional Biochemistry found that Honey, with its variable composition based on botanical origin, exhibits antioxidant and anti-inflammatory properties, suggesting its potential efficacy in managing obesity-related dysfunctions, including neurodegeneration, through improved glycemic control and lipid profile. The review explores honey's therapeutic potential, emphasizing its diverse bioactive compounds. The focus is on its effects in combating obesity-related dysfunctions, supported by experimental evidence from animal studies. Experimental findings indicate that honey can enhance glycemic control and lipid profile, offering protection against endothelial dysfunction and neurodegeneration in obesity. The role of honey's key constituents, particularly polyphenols, is highlighted, underscoring the need for further human studies to confirm these health benefits.

A Systematic Review published in 2020 in the journal Applied Sciences found that Eggplant may possibly be used in the treatment of anemia, atherosclerosis, and fatty degeneration. Eggplant is progressively becoming more well-known due to its composition of carbohydrates, proteins, vitamins, and several other bioactive compounds, such as phenolic acids. Eggplant also contains traces of minerals such as copper, zinc, and iron. Due to this biochemical composition, eggplant may possibly be used in the treatment of anemia, atherosclerosis, and fatty degeneration. Its antioxidant property potentially reduces the risk of various types of cancer, protects against cardiovascular diseases, and prevents acute respiratory infections. Further, eggplant fibers help in digestion by removing toxins and harmful materials from the stomach and reducing colon cancer. Plant polyphenols present in eggplants can help protect cell membranes and boost the brain’s memory function.

A Systematic Review published in 2020 in the journal Evidence-Based Complementary and Alternative Medicine found that The study shows the promising potential of Suan Zao Ren as a multi-effect traditional Chinese medicine derived from the seeds of Ziziphus Jujuba. The methodology of the research was primarily a comprehensive literature review of Ziziphi Spinosae Semen (aka Suan Zao Ren). The team explored the botanical characteristics, traditional uses, pharmacology, and discovered compounds in the seeds of Ziziphus Jujuba. In regards to the results of the review, more than 150 compounds were identified in Ziziphi Spinosae Semen. These compounds, which mainly include terpenoids, flavonoids and others, show various biological activities. It was found that the seeds are particularly prominent in having sedative and hypnotic effects. Other properties discovered include antitumor potential, improvement to learning and memory, anti-inflammatory, antioxidative, anti-aging, alongside lower blood pressure and lipid levels. Traditional usage of the seeds for the treatment of insomnia, forgetfulness, headaches and dizziness were confirmed by the review.

A Experimental Study published in 2020 in the journal Molecules found that Probiotic-enriched mung and adzuki bean sprouts demonstrate increased antioxidant potential and exhibit cytostatic and cytotoxic effects on human stomach cancer cells. The study utilized mung bean sprouts (MBS) and adzuki bean sprouts (ABS), enriched with probiotic strain 299v, and their gastric digests were tested on human stomach cancer cells, AGS. Differentiation was shown through ABS containing quercetin and kaempferol derivatives while MBS featured kaempferol and apigenin derivatives, each displaying a higher antioxidant potential compared to controls. The viability of AGS reduced notably with low concentrations of ABS extracts, displaying inhibitive action which pointed to their cytostatic effects. In discussing the results, it is noticed that the sprouts showcased dose-independent cytostatic effects. However, ABS extracts were found to be more effective in reducing the proliferation of AGS, compared to MBS. Notably, the ABS extracts exerted about 70% inhibitions, elucidating their strong inhibitive power. Concurrently, the phytochemicals from these probiotic-enriched sprouts were observed to reduce the associated activity significantly. Observations of increased vinculin level, apoptotic shape of cell nuclei, alongside decreased cell motility and proliferation provide evidence that these extracts exhibited not only cytostatic but also cytotoxic activity.

A Theoretical Article published in 2020 in the journal Nutrients found that Coffee, like many fruits and vegetables, activates a cellular response that boosts antioxidants and repair enzymes, which contributes to a lower risk of several diseases. The research paper proposes a new perspective on the health benefits of habitual coffee consumption. Instead of focusing on individual elements in coffee, the study compares coffee as a whole, acting as a plant food, with the advantageous properties of many vegetables and fruits. By linking coffee, vegetables and fruits, researchers identified a common mechanism that promotes health - the activation of an adaptive cellular response which leads to an upsurge of proteins involved in cell protection such as antioxidant, detoxifying and repair enzymes. It was also noted that this response hinges on the activation of the Nuclear factor erythroid 2-related factor-2 (Nrf2) system by phenolic phytochemicals, leading to the expression of cell defense genes. The discussion of the paper's results reveals that coffee plays a significant role in health promotion, the main reason being that it is the primary dietary source of phenolic acids and polyphenols in the developed world. Additionally, a supportive function might be associated with the modulation of the gut microbiota by non-digested prebiotic constituents of coffee. Conclusively, the paper suggests that coffee uses similar health promotion pathways as other vegetables and fruits, and that coffee beans could be seen as healthy vegetable food and a leading supplier of dietary phenolic phytochemicals.

A Review Article published in 2020 in the journal Phytotherapy Research found that Ginger, through various methods, exhibits promising pain reduction effects for conditions such as dysmenorrhea, muscle soreness, osteoarthritis, low back pain, and migraines. The review incorporates a vast range of randomized controlled trials conducted over the past decade, where ginger was mainly used for pain relief in distinct conditions. The conditions included dysmenorrhea, delayed onset muscle soreness, osteoarthritis, chronic low back pain, and migraines. The variety of methods used included oral administration, topical application, and aromatic oil massages. In the analysed trials, for dysmenorrhea and muscle soreness, the considered studies suggested a promising effect after both oral and topical administration of ginger. As for osteoarthritis, most trials demonstrated pain reduction following topical and oral use of ginger, one focused on the beneficial effects of ginger in relieving migraine pain. Last but not least, a trial involving massages with aromatic ginger oil highlighted its potential in reducing chronic low back pain.

A Review Article published in 2020 in the journal Current Developments in Nutrition found that Citrus peel flavonoids exhibit a remarkable spectrum of biological activities including anti-inflammatory, anticancer, antiproliferation, antiangiogenesis, antioxidant, cell cycle regulation, and antimetastasis effects. This review has summarized a selection of the key preclinical and clinical studies that show an anticancer utility for citrus-derived flavonoids. This property is linked to the chemical structures of flavonoids, which can dramatically affect a range of molecular and cellular mechanisms for inhibiting cancer initiation and progression. Overall, citrus flavonoids act not only as free radical scavengers but also as modulators of several key molecular events implicated in cell survival and apoptosis.

A Network Pharmacology published in 2020 in the journal Foods found that The antioxidant potential and substance levels in Matcha tea is affected by the harvest period and water temperature used for preparation. The study's methodology was set to evaluate the antioxidant capacity and significant component levels of traditional and daily Matcha green tea, originating from Japan. It focused on the content of essential vitamins, flavonoids, and other polyphenols. The variations in these components were examined by making infusions at different temperatures - 25°C, 70°C, 80°C, and 90°C. Approximately 1.75g of the plant material was used with 100mL of distilled water in these preparations. The comparison was made between Matcha tea from the first and second harvests, as well as from the second and third harvests. In the discussion of results, infusions made from the daily Matcha harvest, especially the one prepared at 90°C, were observed to have the highest amount of substances possessing antioxidant properties. Notably, the concentrations of these beneficial substances tended to vary according to the timing of the plant's harvest and the temperature of water used for infusion preparation. Particularly, flavonoids, polyphenols, and vitamin C showed appreciable fluctuation across these variables, confirming a vital link between preparation details and the health benefits furnished by Matcha green tea.

A Systematic Review published in 2020 in the journal Nutrients found that These reports suggest the benefits of a walnut-enriched diet in brain disorders and in other chronic diseases, due to the additive or synergistic effects of walnut components for protection against oxidative stress and inflammation in these diseases. Walnuts contain several components that have antioxidant and anti-inflammatory effects. Animal and human studies from our and other groups suggest that supplementation with walnuts in the diet may improve cognition and reduce the risk and/or progression of mild cognitive impairment and Alzheimer's disease. Furthermore, several animal and human studies have suggested that walnuts may also decrease the risk or progression of other brain disorders such as Parkinson’s disease, stroke, and depression, as well as of cardiovascular disease and type 2 diabetes. Together, these reports suggest the benefits of a walnut-enriched diet in brain disorders and in other chronic diseases, due to the additive or synergistic effects of walnut components for protection against oxidative stress and inflammation in these diseases.

A Review Article published in 2020 in the journal Phytotherapy Research found that Star anise is the source of the precursor molecule, shikimic acid, which is used in the manufacture of oseltamivir (Tamiflu®), an antiviral medication for influenza A and influenza B. Besides, several other molecules with numerous biological benefits including the antiviral effects have been reported from the same plant. Except the antiviral potential, star anise possesses a number of other potentials such as antioxidant, antimicrobial, antifungal, anthelmintic, insecticidal, secretolytic, antinociceptive, anti-inflammatory, gastroprotective, sedative properties, expectorant and spasmolytic, and estrogenic effects.

A Network Pharmacology published in 2020 in the journal Nutrients found that Ganpu tea, derived from Pu-erh tea and the pericarp of Chachi, enhances antioxidant capacities and modulates gut microbiota beneficially more than Pu-erh tea alone. A thorough chemical analysis was conducted on hot-water extracts of Ganpu tea using ultra-high performance liquid chromatography and quadrupole-time-of-flight tandem mass spectrometry, which identified a total of 92 constituents. Considering the antioxidant properties of Ganpu tea, an experiment was designed and carried out where rats were fed with Ganpu tea over a long period. The same experiment was done using Pu-erh tea and the pericarp of Chachi separately, allowing for comparisons of antioxidant capacities between them and Ganpu tea. The results showed that Ganpu tea had a substantial impact on improving the activities of superoxide dismutase and glutathione peroxidase, both essential antioxidants, more than Pu-erh tea. This indicated a superior antioxidant capacity of Ganpu tea. Further, it significantly increased the abundance of specific gut bacteria, offering a suggestion of the potential benefits of Ganpu tea in human gut microbiota modulation. The results underscore the health benefits of Ganpu tea in enhancing antioxidant activities and promoting beneficial gut microbiota.

A Review Article published in 2020 in the journal The American Journal of Chinese Medicine found that The Chrysanthemum indicum L. plant has been discovered to have multiple pharmacological capabilities including anti-inflammatory, antioxidation, antipathogenic, anticancer, immune regulation, and hepatoprotective effects. In their study, the researchers undertook an extensive review of Chrysanthemum indicum L., a longstanding staple of traditional Chinese medicine. They examined the botany, phytochemistry, and pharmacology of the plant, integrating historical records relating to traditional medicinal usage with modern scientific analyses. In the discussion of their findings, they made note of the plant's impressive pharmacological portfolio. More than 190 chemical compounds have been identified within the plant, including flavonoids, terpenoids, phenylpropanoids, and phenolic acids. These contribute to a variety of medical benefits - illustratively, its extracts show anti-inflammatory and anti-oxidation properties, and compounds isolated from the plant suggest potential anticancer, antipathogenic microorganism, immune regulation, and hepatoprotective effects.

A Review Article published in 2020 in the journal Antioxidants in Fruits: Properties and Health Benefits found that Avocado, particularly the Hass variety, has substantial health benefits due to its rich contents of nutrients, fiber, and bioactive constituents including antioxidants. The methodology of the paper involves a comprehensive overview of avocado, focusing on the extensively cultivated Hass variety. The research explored various components of the avocado which include not only the fruit, but also the seeds, leaves, and skin. These parts were analyzed for their nutritional and bioactive constituents such as phytochemicals, phytosterols, vitamins and minerals. Furthermore, the use of avocado leaves in traditional medicine, the rich composition of the peel and seeds, and the potential health benefits of avocado oil were investigated. The discussion of results revealed that avocados, particularly Hass avocados, are a substantial source of beneficial nutrients, fiber, and bioactive components. It was found that leaves of the avocado have antioxidant properties and are used in traditional medicine. The peel and seeds showed a rich content of phenolic compounds, starch, and fiber. The research also determined that avocado oil presents health advantages and can be used as a good alternative substitute for olive oil. Avocados are largely consumed as a vegetable, often in combination with other ingredients.

A Systematic Review published in 2019 in the journal Food Reviews International found that Sesame consumption significantly increases enzymatic (superoxide dismutase, glutathione peroxidase, catalase) and non-enzymatic (vitamin C, vitamin E, β-carotene, and glutathione) antioxidants. Meta-analyses revealed that sesame consumption significantly increases enzymatic (superoxide dismutase, glutathione peroxidase, catalase) and non-enzymatic (vitamin C, vitamin E, β-carotene, and glutathione) antioxidants. However, no significant effect was observed on malondialdehyde (MDA), total antioxidant capacity and α-tocopherol levels. It was shown that MDA levels significantly decreases only when sesame seeds were used for supplementation. Sesame consumption is associated with improved oxidative status. High quality randomized controlled clinical trials from diverse regions are still needed.

A Review Article published in 2019 in the journal Antioxidants found that Avocado's nutritional and therapeutic properties show potential for novel drug discovery in prevention and treatment of prevalent diseases such as cancer, diabetes, and cardiovascular issues. The methodology utilized in this review was an extensive summary and assessment of research conducted in recent decades with emphasis on avocado's nutritional and therapeutic properties, along with its unique biochemical profile. Special focus was given to the major metabolites of avocado, their antioxidant properties, as well as their bioavailability and pharmacokinetic features. The discussion of results involved highlighting the potential of avocado in novel drug discovery for the prevention and treatment of a variety of diseases like cancer, microbial, inflammatory, diabetes, and cardiovascular diseases. Emanating from the unique bioactive compounds and antioxidant contents of avocado, it’s clear that the fruit has much more to offer in terms of medicinal value than is currently explored today.

A Review Article published in 2019 in the journal Evidence-Based Complementary and Alternative Medicine found that Honey can protect the bone via its antioxidant and anti-inflammatory properties, primarily through its polyphenol content that acts upon several signalling pathways, leading to bone anabolic and antiresorptive effects. This review aims to summarize the current evidence on the effects of honey on bone health. The evidence reported so far indicates a skeletal-beneficial effect of honey in animal models of osteoporosis. However, the number of studies on humans is limited. The literature shows that honey has promising skeletal-beneficial effects in preventing osteoporosis. Many types of honey have been shown to prevent bone loss in various animal models via its high antioxidant and anti-inflammatory properties. Nevertheless, the efficacy of honey seems to be dose-dependent, whereby very high or low dosage will not produce desirable results on the skeleton.

A Review Article published in 2019 in the journal Agricultural Reviews found that Cocoa and cocoa products, enriched with polyphenols, have potential health benefits including enhanced vascular function, cancer prevention, and improvement in learning and memory. The authors carried out an extensive review of the nutritional profile of cocoa beans, focusing on the high content of carbohydrates, protein, fat, fiber, and minerals. Significantly, they pinpointed bioactive compounds, especially polyphenols (flavonoids and nonflavonoids), as key constituents, attributing to cocoa its antioxidant and anti-inflammatory properties. Emphasis was placed on the consumption of flavonoid-rich chocolates and its potential health benefits. The findings of the research underscore multiple health benefits from cocoa's flavonoids. These include an improvement in peripheral vascular function and a suppression of molecular processes linked with cancer. Notably, the flavonoids have been observed to heighten insulin sensitivity and reduce oxidative damage. They also seem to concentrate in brain areas associated with learning and memory. These insights collectively support the integration of cocoa and its products as a part of a nutritious and balanced diet.

A Review Article published in 2019 in the journal Applied Ecology and Environmental Research found that Chrysanthemum, rich in unique chemical compounds, offers significant health benefits such as stress relief, cardio protection, immunity boost, improved eye health, and osteoporosis risk reduction. The study primarily focuses on evaluating the most important chemical extracts of chrysanthemum. These include flavonoids, betaine, choline, and vitamin B1. Further, the researchers identified thirteen compounds unique to chrysanthemum flowers. These were extracted and analyzed to unveil their potential health benefits. In the discussion of results, the authors highlight chrysanthemum's impressive range of health benefits stemming from its chemical composition. It is revealed that chrysanthemum can potentially alleviate stress and anxiety while improving cardiovascular health. It also has properties to guard against oxidative damage and inflammation, support a healthy immune function, enhance eye health, and lessen the risk of osteoporosis. Interestingly, the herb's beneficial traits align with its traditional use in Chinese medicine, underscoring chrysanthemum's potential in promoting holistic, organic health.

A Experimental Study published in 2019 in the journal Folia Medica found that The pectin-free fraction of Lycium barbarum, or goji berry, strongly inhibits growth in breast cancer cells, and this effect is enhanced by adding polysaccharides. In this study, the researchers isolated three fractions of Lycium barbarum, also known as goji berry, and tested their antioxidant activity using Oxygen Radical Absorbance Capacity and Hydroxyl Radical Averting Capacity assays. After this, the antiproliferative effects of these extracts were evaluated on three separate breast cancer cell lines. To see the influence of different components of the berry, a distinct pectin-free fraction was used and its effects were studied in conjunction with those of added polysaccharides. The results indicate that the pectin-free fraction produced the most significant growth inhibitory effect on the breast cancer cells. This inhibitory effect was found to be enhanced when polysaccharides were added to the pectin-free fraction. A determining factor for the observed effects seemed to be the polyphenolic content of the extracts, with higher content correlating to stronger effects.

A Experimental Study published in 2019 in the journal Folia Medica found that The pectin-free fraction from Lycium barbarum fruit exhibits significant antioxidant activity and inhibits the growth of breast cancer cells. In this study, researchers took three portions from Lycium barbarum fruit – total water, pectin-free, and polysaccharide, and analyzed their antioxidant potential using Oxygen Radical Absorbance Capacity and Hydroxyl Radical Averting Capacity assays. The team also examined the pectin-free and the polysaccharide fraction's antiproliferative effects on non-tumorigenic and tumorigenic breast cell lines through the MTT dye reduction assay. The results revealed that the pectin-free fraction from Lycium barbarum fruit demonstrated growth inhibition in a concentration-dependent manner on the three cell lines. This effect was highly pronounced on the breast cancer cells. The polysaccharide fraction showed limited activity, only reducing the proliferation of one type of breast cancer cell at maximum concentration. Surprisingly, pairing the pectin-free and polysaccharide fraction did not produce a synergistic effect. A relationship was observed between the polyphenolic content in the extracts and the resulting effects, with the pectin-free extract containing the most polyphenols and demonstrating the most potent antioxidant and antineoplastic impact against breast cancer cells.

A Systematic Review published in 2019 in the journal Nutrients found that Bioactive compounds present in different parts of radishes, such as leaves, sprouts, stem and roots, act on a variety of potential drug targets associated with ailments, such as cancer, inflammation, liver injury and diabetes. Radishes is of great pharmaceutical importance, most of which has been attributed to its antioxidant property. The administration of radish extracts under numerous pathological conditions aids in the recovery of diseases and in the prevention of harmful ailments because of their attributed bioactivities. Bioactive compounds present in different parts of radishes, such as leaves, sprouts, stem and roots, act on a variety of potential drug targets associated with ailments, such as cancer, inflammation, liver injury and diabetes. However, the in-depth molecular mechanistic studies are required to address the regulatory roles of bioactive compounds in radish extracts. In future, researches focusing on the determination and pharmacokinetic elucidation of the bioactive compounds in radishes could facilitate the designing of plant based drugs for life threatening disorders, such as cancer and diabetes. Overall, the knowledge gained from the present researches in radish should be utilized in the discovery of novel drug molecules with higher efficacy towards drug targeting with less side effects.

A Systematic Review published in 2019 in the journal Critical Reviews in Food Science and Nutrition found that Black pepper, beyond its culinary use, offers medicinal benefits like antimicrobial, antioxidant, anticancer, anti-diabetic, and anti-inflammatory properties mainly attributed to the compound piperine. The study was a systematic review of existing scientific data on the traditional uses, composition, and pharmacological attributes of black pepper. Information was gathered from recognized databases such as Science Direct and Google Scholar, as well as books and other online resources. The study primarily focused on literature in English and evaluated traditional medicinal uses of black pepper in various regions, the common ailments it was used to address, and the preferred modes of preparation. The results of the study affirm the significant medicinal qualities of black pepper. Its antimicrobial activity was demonstrated against various pathogens, and it showed strong antioxidant effects against several reactive oxygen and nitrogen species. The research also highlighted the anticancer effects of black pepper on cell lines from various sites including breast, colon, cervix, and prostate. Furthermore, the benefits of black pepper in managing diabetes and lipid levels in the body were also confirmed. It was also noted for its anti-inflammatory, analgesic, anticonvulsant, and neuroprotective effects. Piperine was identified as the major bioactive compound in black pepper which is responsible for these beneficial effects along with other compounds such as piperic acid, piperlonguminine, and more.

A Systematic Review published in 2019 in the journal Oxidative Medicine and Cellular Longevity found that The health benefits of goji berries include enhancing hemopoiesis, antiradiation, antiaging, anticancer, improvement of immunity, and antioxidation. Goji berries are a high antioxidant potential fruits which alleviate oxidative stress to confer many health protective benefits such as preventing free radicals from damaging DNA, lipids, and proteins. There is a better protection through synergistic and additive effects in fruits and herbal products from a complex mixture of phytochemicals than from a single phytochemical. The health benefits of goji berries include enhancing hemopoiesis, antiradiation, antiaging, anticancer, improvement of immunity, and antioxidation.

A Systematic Review published in 2019 in the journal Oxidative Medicine and Cellular Longevity found that Goji berries, rich in antioxidants, confer health benefits including protection against aging, cancer, and radiation, as well as enhancing immunity and blood production. The methodology of the study focused on a thorough review of the bioactive compounds and pharmacological properties of goji berries, particularly targeting their molecular mechanisms of action. This involved looking at the different ways these fruits are consumed, such as in soups, herbal teas, tinctures, wine, and juice, and how these methods influence the antioxidants present in the fruits. Goji berries were found to offer a range of health benefits due to their ability to alleviate oxidative stress. These benefits include enhancing hemopoiesis (blood formation), offering antiradiation and antiaging properties, inhibiting cancer, improving immunity, and providing antioxidation. Furthermore, the study emphasized that the complex mixture of phytochemicals found in fruits and herbal products like goji berries provide a cumulative protective effect, which proves more beneficial compared to extracting and using one single phytochemical.

A Network Pharmacology published in 2019 in the journal Molecules found that Raw pu-erh tea extract has superior antioxidant capacity due to higher polyphenol content, but ripe pu-erh offers a cheaper, yet effective alternative for antioxidant or antimicrobial properties. The investigation first utilised mass spectrometry and UV spectroscopy to profile and quantify the primary components of two types of fermented Chinese green tea - raw and ripe pu-erh. This took place after a procedure known as chromatographic separation, used to separate the components of the extract. Beyond this, the activities of the extracts, relating to antioxidant potential, antimicrobial capability and enzyme inhibition, were established and linked to their main components. In discussing the results, though having similar caffeine content and equivalent enzyme inhibition and antimicrobial activities, raw pu-erh extract demonstrated a stronger antioxidant ability owing to it containing a higher concentration of polyphenols. However, the benefits of raw pu-erh tea do not provide enough justification for its higher production costs in comparison to the ripe variety. The ripe variety of pu-erh tea was shown to be a cost-effective alternative for creating products with antioxidant or antimicrobial characteristics.

A Systematic Review published in 2019 in the journal BMC Complementary Medicine and Therapies found that Peppermint oil has been shown to be a safe and effective treatment for pain and overall symptoms in adults suffering from irritable bowel syndrome. In their research, the authors conducted a systematic search across numerous scientific databases, including, but not limited to, MEDLINE, Cochrane Central Register of Controlled Trials, ClinicalTrials.gov, EMBASE, and Web of Science. The aim was to find randomized controlled trials that investigated the effects of peppermint oil on irritable bowel syndrome. They assessed the eligible studies using the Cochrane risk of bias tool. The primary outcomes they concentrated on were global improvement in irritable bowel syndrome symptoms and abdominal pain. Through their intensive research, they were able to include twelve randomized trials with 835 patients. They performed a random-effects meta-analysis on the primary outcomes. Peppermint oil was found to significantly improve global symptoms and reduce abdominal pain. This demonstrated that peppermint oil could be a beneficial treatment option for irritable bowel syndrome patients.

A Randomised Controlled Trial published in 2019 in the journal Food & Function found that Daily consumption of tart cherry juice may enhance cognitive abilities in older adults, likely due to reduction of hypertension, inflammation, and oxidative stress. In this randomized controlled trial, 37 adults aged between 65 and 80 years with normal cognitive function were assigned to consume two cups of Montmorency tart cherry juice daily for a duration of 12 weeks. Participants' subjective memory and objective cognitive performance were evaluated at the starting point and after the 12-week juice supplementation using a validated memory questionnaire and a standard assortment of tests designed for cognitive assessment. Factors such as daily caloric intake and physical activity levels were also monitored during the study. After the 12-week intervention, participants who consumed tart cherry juice showed an improvement in their contentment with memory scores, demonstrated decreased scores of movement time, and performed better on a task of paired associates learning when compared to the control group. Notably, the results revealed that the tart cherry juice group demonstrated improvements on measures of visual sustained attention and spatial working memory relative to their own baseline values. These findings suggest that the potential benefits of tart cherry juice to cognitive abilities might be attributed to the juice's antioxidant and anti-inflammatory properties, and its capacity to reduce blood pressure.

A Network Pharmacology published in 2019 in the journal Molecules found that The purple chrysanthemum tea, imbued with unique antioxidants and affected by infusion time, showed comparatively higher antioxidant activity than the yellow chrysanthemum. Methodologically, the researchers used a variety of testing methods to analyze the phytochemical composition and antioxidant activity of the γ-irradiated mutant chrysanthemum cultivar with dark purple petals (ARTI-Dark Chocolate) and the conventional yellow variety (Gamguk). The influence of different water temperatures and infusion time on the content and activity was also investigated. In addition, the floral scent of both tea types were investigated using spectrometry. Discussion of the results indicates that the phytochemical profiles of both the yellow and purple chrysanthemum teas varied significantly. Purple chrysanthemum tea contained anthocyanins and linarin, which were not present in the yellow variety, and had higher levels of certain compounds. The infusion time and temperature also impacted the purple variety more than the yellow, with the highest total compound content appearing at 100 °C after 4 minutes of infusion. In the antioxidant tests, the purple chrysanthemum tea demonstrated superior antioxidant activity, which was attributed to its high anthocyanin content. In all infusing conditions, both teas presented strong radical scavenging effects.

A Review Article published in 2019 in the journal Therapeutic Advances in Musculoskeletal Disease found that Cherries and their products have antioxidant properties, the capacity to inhibit the acute inflammatory response to urate crystals, and the ability to decrease bone resorption that is characteristic of gouty bone erosions. Phenolics, and more specifically, the anthocyanins found abundantly in cherries, have been linked to the inhibition of IL-6, TNF-α, IL-1β, IL-8, COX-I and COX-II, as well as the downregulation of NFkB-mediated osteoclastogenesis, suggesting that cherries may have the ability to reduce both acute and chronic inflammation that play a role in recurrent gout flares and chronic destructive arthropathy. Additionally, cyanidin-3-glucoside enhanced genes related to osteoblast differentiation, suggesting that anthocyanins may also play a role in bone formation.

A Theoretical Article published in 2019 in the journal Applied Ecology and Environmental Research found that Chrysanthemum, a plant primarily grown in China and Japan, offers significant health benefits including stress reduction, cardiovascular improvement, and lowering osteoporosis risk. The study focused on Chrysanthemum, a notable plant in the ornamental industry and traditional Chinese medicine, mainly grown in China and Japan. The researchers identified its crucial chemical extracts such as flavonoids, betaine, choline, and vitamin B1. They additionally pinpointed thirteen significant compounds of chrysanthemum flowers, including acacetin-7-0-beta- D-glucopyranoside, luteolin, acaciin, and boscialin, among others. The findings revealed that chrysanthemum tea exhibits considerable health advantages. It eases stress and anxiety, enhances cardiovascular health, protects against oxidative damage, inhibits inflammation, supports healthy immune function, ameliorates eye health, and decreases the risk for osteoporosis. In traditional Chinese medicine, chrysanthemum is considered a cold herb that dispels pathogenic heat, aids the liver, improves eyesight, and promotes detoxification. The study, therefore, endorsed the treatment with natural Chinese herbal medicine, especially chrysanthemum, over synthetic drugs for a more organic life.

A published in 2018 in the journal PeerJ found that Phytochemicals including phenolics and flavonoids in citrus peel extracts exhibited good antioxidant properties. Among the extracts, 70% AEC with highest total phenolic content and high total flavonoid content showed greatest antioxidant activity in all three assays. Different phenolic acids, organic acids and flavonoids were also identified from the extracts. This study indicated that C. sinensis peels contained potential antioxidant compounds which could be exploited as value added products in the food industry.

A Review Article published in 2018 in the journal Frontiers in Pharmacology found that Lycopene may improve vascular function and contributes to the primary and secondary prevention of cardiovascular disorders. The main activity profile of lycopene includes antiatherosclerotic, antioxidant, anti-inflammatory, antihypertensive, antiplatelet, anti-apoptotic, and protective endothelial effects, the ability to improve the metabolic profile, and reduce arterial stiffness. In this context, lycopene has been shown in numerous studies to exert a favorable effect in patients with subclinical atherosclerosis, metabolic syndrome, hypertension, peripheral vascular disease, stroke and several other cardiovascular disorders, although the obtained results are sometimes inconsistent, which warrants further studies focusing on its bioactivity.

A Systematic Review published in 2018 in the journal Food Science and Human Wellness found that The consumption of mung beans and sprouts in regular basis are not only providing nutrients, but also maintains the microbial flora in the gut, reduces the absorption of toxic compounds, decreases the menace of obesity, hypercholesterolemia, and cardiovascular diseases, and also prevents cancer and diabetes. Based on the high constituents and efficacy of the bioactive compounds, mung beans are playing a greater role in radical scavenging activities, detoxification, and also exhibits chemo-preventive effects. These compounds have the potential health benefit as a complementary and alternative medicine which is exerted for its antioxidant, hepatoprotective, antibacterial, antifungal, antiviral, cardioprotective, anti-inflammatory, antidiabetic, anticancer, anti-obesity, hypolipidemic, and potent chemopreventive properties.

A published in 2018 in the journal BioMed Research International found that Citrus limon extracts could be a promising antioxidant source for the prevention and/or treatment of oxidative stress-related diseases. Extracts from Citrus limon exhibit powerful antioxidant properties, expressed by its capacity to scavenge DPPH radicals and to reduce power, and the extracts reduce H2O2-induced DNA via its antioxidant activities. These antioxidant activities and inhibitory effects of the extracts on DNA and cell damage may further prove that Citrus limon is useful as a medicinal plant for cancer chemoprevention. The results obtained show that Citrus limon extracts contain high enough levels of phenolic and flavonoid compounds. This is correlated with a remarkable antioxidant activity towards the reduction of iron, and a relatively high power against scavenging free radicals.

A Review Article published in 2018 in the journal Oxidative Medicine and Cellular Longevity found that Honey, a natural food supplement, emerges as a potent therapeutic antioxidant with diverse medicinal effects, including wound healing, antibacterial, anti-inflammatory, antifungal, antiviral, and antidiabetic properties, suggesting its potential as a novel antioxidant in managing oxidative stress-related diseases. The research extensively reviews honey's medicinal effects, emphasizing its role as a therapeutic antioxidant. The study explores various mechanisms, including the modulation of multiple signaling pathways and molecular targets. The evidence-based research underscores honey's role in alleviating diseases linked to oxidative stress. The reviewed pathways include caspase induction, cytokine stimulation, cell cycle regulation, and modulation of inflammatory markers. The comprehensive exploration of honey's therapeutic potential indicates its promise as a standalone or adjuvant antioxidant, necessitating further experimental and clinical investigation.

A Clinical Study published in 2017 in the journal Journal of Food Science found that Adding fresh herbs like parsley and chives to air-fried sardines reduces the levels of harmful cholesterol oxidation products formed during cooking. To conduct this study, sardine fillets were air fried, a method considered healthier as it allows frying without oil. The research then revolved around the monitoring of two types of substances: cholesterol oxidation products (COPs), theorised to increase with the high heat, and essential polyunsaturated fatty acids (PUFAs), which typically decrease in such conditions. In the analysis of the results, it was observed that, indeed, cooking through air frying escalated the levels of COPs while diminishing that of essential PUFAs. The experiment further introduced fresh herbs, namely parsley, chives and a mix of both, owing to their properties as natural antioxidants. This addition was observed to lower the levels of COPs formed, indicating a healthier outcome. Specifically, air-fried sardines with 4% cheiro-verde (the mixed herbs) offered the best protection against lipid or fat oxidation.

A Systematic Review published in 2017 in the journal Nutrients found that Radish has been identified as having antidiabetic effects, making it favorable for those with diabetic conditions. This may be due to its ability to enhance the antioxidant defense mechanism and reduce the accumulation of free radicals, affect hormonal-induced glucose hemostasis, promote glucose uptake and energy metabolism, and reduce glucose absorption in the intestine. However, this summary requires further confirmation in research in vivo studies and clinical trials.

A Experimental Study published in 2017 in the journal Natural Product Research found that Pumpkin seeds have a higher total phenolic compound content, but phenolic compounds from amaranth grains show stronger antiradical properties. The researchers extracted phenolic compounds from pumpkin seeds and amaranth grains using an 80% methanol solution. They then characterised these extracts by their total phenolic compound contents, antioxidant capacities, antioxidant power, and their antiradical activity against a given radical. The individual phenolic compounds were identified with a method known as high-performance liquid chromatography with diode-array detection. They found that pumpkin seeds had a higher total phenolic compound content than amaranth grains. However, phenolic compounds from amaranth grains demonstrated a stronger ability to neutralize the radical they were testing against. They also found several peaks on the chromatograms of two extracts, indicative of different compounds and their concentrations. Vanillic acid derivatives were confirmed in the amaranth grains, while in the pumpkin seeds, they identified three main phenolic compounds based on their ultraviolet diode-array detection spectra.

A Review Article published in 2016 in the journal Arabian Journal of Chemistry found that Fennel exhibits antifungal, antibacterial, antioxidant, antithrombotic and hepatoprotective activities. Fennel is a medicinal and aromatic plant with a diverse pharmacological spectrum and having considerable importance in particular to food industry. Its aroma active compounds such as anethole (and its polymers like dianethole and photoanethole) estragole, (+)-Fenchone and P-anisaldehyde have been recognised as the biologically active molecules possessing oestrogenic, acaricidal and antithrombotic activities. The phenolic molecules present in fennel have been shown to possess potent antioxidant activity in a number of experiments. These bioactive molecules in fennel can be developed as novel pharmacological lead molecules provided their bioavailability, pharmacokinetics, physiological pathways, and importance to human health are known with sufficient detail.

A Network Pharmacology published in 2016 in the journal Molecular Medicine Reports found that Purified polysaccharides extracted from Tremella aurantialba mycelium have improved antioxidant properties and stimulate immune response in macrophage cells. The study researched the physiochemical and biological properties of crude and purified mycelium polysaccharides from Tremella aurantialba mycelium. A series of physiochemical properties were examined including total sugar, uronic acid and protein content, monosaccharide type and structure, as well as molecular weight. The antioxidant activity of these polysaccharides was studied via their reducing power and scavenging activity of different radicals. Additionally, the study evaluated the potential immunostimulatory activity of these polysaccharides by examining their effects on the proliferation, nitric oxide production and cytokine secretion of a certain type of cell. In the results, it was found that the purified mycelium polysaccharide consisted mainly of three types of sugars and its molecular weight was determined. Comparing the total carbohydrate content, it was discovered that the purified mycelium polysaccharide has significantly higher carbohydrate content compared to its crude counterpart. From the analysis of antioxidant and immunostimulatory activities, the purified polysaccharide showed improved antioxidant properties and the ability to induce macrophage proliferation, nitric oxide production and secretion of several chemicals involved in immune response. This indicates a possible correlation between the total carbohydrate content and the enhanced antioxidant and immunostimulatory activities.

A Experimental Study published in 2016 in the journal Food Chemistry found that In 2004, polyphenols were isolated from mung bean sprouts, which exert antibacterial activity against Helicobacter pylori, one of the most common causative organisms in gastrointestinal disorders. The utility of bioactive compounds from food legumes as natural antimicrobial agents are commonly known as biocides. Mung bean sprouts have potent antiviral and prophylactic activities against respiratory syncytial virus and Herpes Simplex virus −1, and these activities were comparable with Acyclovir. The underlying mechanism was attributed to active components of mung bean sprouts potentially induce antiviral cytokines in human cells and thereby nullify the actions on viral proliferation. Similarly, antifungal and antiviral potency of two beans proteins, designated alpha (28 kDa) and beta (28 kDa) proteins were isolated and were capable of inhibiting human immunodeficiency virus reverse transcriptase and glycohydrolases associated with HIV infection. Further, antifungal peptides (7.3 kDa, 9.03 kDa) were isolated from beans, which exerted an antifungal effects and inhibited mycelial growth in Fusarium oxysporum, F. solani, Pythium aphanidermatum, Sclerotium rolfsii, Mycosphaerella arachidicola, and antibacterial effects on Staphylococcus aureus. In addition, two proteins, Mungin (18-kDa) and chitinase (30.8 kDa) isolated from mung bean seeds possess antifungal activity against Rhizoctonia solani, Coprinus comatus, Mycosphaerella arachidicola, Botrytis cinerea, and Fusarium oxysporum. Mungin and chitinase exert an inhibitory activity against α- and β-glucosidases, suppressing [3H] thymidine in the corporation by mouse splenocytes. In 2004, polyphenols were isolated from mung bean sprouts, which exert antibacterial activity against Helicobacter pylori, one of the most common causative organisms in gastrointestinal disorders. Furthermore, several in vitro and in vivo studies have also been reported that mung bean seeds are protective against sepsis.

A Systematic Review published in 2016 in the journal Phytotherapy Research found that Plums display anti-inflammatory, antioxidant properties and can enhance memory, and their consumption shows potential health benefits for cognitive function, bones, and cardiovascular elements. In this systematic review, the researchers explored the health effects of plums by analyzing articles from numerous databases in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The research spanned across in vitro studies, animal trials, and human clinical trials, and included studies relating to the Prunus species of plums. Their focus was on the potential influence of plums on disease risk factors and health outcomes. The study found 73 relevant peer-reviewed articles for the review, of which 25 were human studies. The results of the study indicate that plums have antioxidant and anti-allergy properties. Consumption of plums is also related to improved cognitive functionality, better bone health measures, and reduced cardiovascular risk factors. The majority of human trials have used dried plums rather than fresh, which could potentially limit the translation of the findings into practical dietary advice. The evidence, while promising, is not yet extensively documented and requires further support for its claims.

A Animal Study published in 2016 in the journal Scientific Reports found that Dried plum was found to be most effective in reducing bone resorption and preventing bone loss caused by ionizing radiation exposure. The methodology of the study involved evaluating different interventions with antioxidant or anti-inflammatory activities; these included an antioxidant cocktail, dihydrolipoic acid, ibuprofen, and dried plum. These substances were tested for their ability to reduce the expression of resorption-related genes in marrow cells after these cells were exposed to gamma rays or simulated space radiation. This involved monitoring the effects on key genes related to bone resorption like Nfe2l2, Rankl, Mcp1, Opg, and TNF-α. In the discussion of results, dried plum was highlighted as the most effective intervention in reducing the expression of genes related to bone resorption. It significantly blunted the gene effects which tend to escalate bone-loss. Moreover, dried plum was additionally effective in preventing later cancellous bone loss caused by irradiation, either from photons or heavy ions. The finding suggests that dietary supplementation with dried plum might offset the skeletal effects of radiation exposures, whether in the context of space or on Earth.

A Review Article published in 2015 in the journal Food and Agricultural Immunology found that Adzuki beans possessed strong ABTS free-radical-scavenging capacity and α-glucosidase inhibition activity. All the adzuki beans possessed strong ABTS free-radical-scavenging capacity and α-glucosidase inhibition activity. Significant positive correlations of the antioxidant activity with total phenolic acids, total flavonoids and free caffeic acid contents were observed. These results are anticipated to providing useful information on the development of adzuki bean-based functional food.

A Systematic Review published in 2015 in the journal Journal of Functional Foods found that Goji berry was identified as a rich source of antioxidant compounds, with health-promoting properties comparable with other common fruit species. A number of things lead to the confusion between the different species and genotypes of cultivated Lycium. In this study, wolfberry was identified as a rich source of antioxidant compounds; the observed analytical fingerprint demonstrated that the species represents a rich source of organic acids and polyphenolic compounds, especially cinnamic acids and catechins; this research suggested that identified nutraceuticals might contribute to the total phytocomplex of these fruits. This study developed an important tool to assess goji chemical composition and bioactivity, using different chromatographic methods for comprehensive authentication and quality control of its fruits: well-designed clinical trials with phytochemically well-characterized extracts are required before the potential of goji as a medicinal plant or food can be definitively assessed. Goji berry fruit is devoid of toxicity but caution is advised with regard to possible drug interactions as well as with products of unknown or dubious origin; for this reason, the development of rigorous quality control protocols for goji products is urgently needed: this research showed that analytical fingerprinting could be an important tool to assess quality, chemical composition, and bioactivity of wolfberry fruits, helping to find new sources of natural health-promoting compounds.

A Systematic Review published in 2015 in the journal Journal of Functional Foods found that The antioxidants present in goji berries have comparable health-promoting properties to those found in other common fruits. The researchers studied the quality traits of goji berries and the levels of potentially fruitful compounds. They employed high-performance liquid chromatography (HPLC) - a technique widely-used to identify and separate components in a mixture - to examine the health-promoting compounds in goji berries, comparing these to what's found in other common fruits. The researchers found that goji berries are a rich source of antioxidant compounds. It was determined that their health-promoting properties are akin to those of other common fruits. The characteristic "fingerprint" obtained through this study could help improve our understanding of this fruit, which is increasingly being recognized as a functional food due to its antioxidant properties.

A Experimental Study published in 2015 in the journal Phytotherapy Research found that Two new compounds found in Chrysanthemum indicum flowers have strong antioxidant qualities and are potent in anti-osteoporosis activity. The research involved the isolation of two new compounds from Chrysanthemum indicum flowers, alongside 17 known compounds. Each compound was then measured for total phenolic and flavonoid content. The research demonstrated the highest concentration of these beneficial compounds within the Ethyl Acetate (EtOAc) fraction of the sample. An assessment of the antioxidative potential of each compound was conducted next, mainly focusing on their peroxyl radical-scavenging capacity and their ability to reduce copper ions. The results confirmed that the two new compounds discovered displayed strong antioxidative effects. These compounds also showed promising activity against tartrate-resistant acid phosphatase in receptor activator of the nuclear factor in osteoclastic cells, suggesting potential efficacy as agents in combatting osteoporosis. Beyond these new compounds, several other compounds isolated from the Chrysanthemum indicum also demonstrated strong antioxidative and anti-osteoporotic activity.

A Systematic Review published in 2014 in the journal BMC Chemistry found that Germination is thought to improve the nutritional and medicinal qualities of mung beans. In recent years, studies have shown that the sprouts of mung beans after germination have more obvious biological activities and more plentiful secondary metabolites since relevant biosynthetic enzymes are activated during the initial stages of germination. During the germination process of the mung bean, its chemical constituents undergo a series of biochemical reactions. One such reaction is the synthesis of small active compounds from macromolecular substances, promoting absorption and utilization. Another change observed during germination is the formation and accumulation of many types of active substances, such as polyphenols, saponins, vitamin C, etc. Therefore, we believes that these changes in the chemical composition of mung beans during germination will lead to substantial and important changes in the pharmacological activities of mung beans as well.

A Systematic Review published in 2014 in the journal BMC Chemistry found that A study demonstrated that all pro-inflammatory cytokines, including interleukin (IL)-1β, IL-6, IL-12β, tumor necrosis factor (TNF)-α, and inducible NO synthase (iNOS), were dramatically down regulated in cells treated with 3.7 mg/mL polyphenols. In Asia, mung beans have been used in various cuisines and in folk remedies to treat toxic poisoning, heat stroke associated with thirst, irritability, and fever; these beneficial effects of mung beans are thought to be related to the inflammatory response. Researchers have analyzed the anti-inflammatory effects of mung bean ethanol extracts on lipopolysaccharide (LPS)-stimulated macrophages. The extract mainly included polyphenols, gallic acid, vitexin, and isovitexin and markedly reduced the activity of murine macrophages through the prevention of pro-inflammatory gene expression without cytotoxicity. Moreover, a study demonstrated that all pro-inflammatory cytokines, including interleukin (IL)-1β, IL-6, IL-12β, tumor necrosis factor (TNF)-α, and inducible NO synthase (iNOS), were dramatically down regulated in cells treated with 3.7 mg/mL polyphenols. These results suggested that the ethanol extract had great potential to improve the clinical symptoms of inflammation-associated diseases, such as allergies and diabetes. The immune modulatory activities of mung bean water extracts and monomers on human peripheral blood mononuclear cells (PBMCs) have also been evaluated by BrdU immunoassay, secretion of interferon-gamma (IFN-γ) and IL-10, and elucidation of the responding cells by flow cytometry. The results demonstrated that 20 μg/mL genistein, phytic acid, and syringic acid induce a Th1-predominant immune response through significant suppression of IL-10 secretion and promotion of IFN-γ secretion. The study concluded that several non-nutritional ingredients of mung beans, such as flavonoids, acids, and plant hormones, are most likely to be important in the modulation of human immunity.

A Systematic Review published in 2014 in the journal BMC Chemistry found that Mung bean protein, tannin, and other polyphenols are thought to combine with organophosphorus pesticides, mercury, arsenic, and other heavy metals, promoting the excretion of sediments from the body. In ancient books, mung beans were well known for their detoxification activities. Mung bean protein, tannin, and other polyphenols are thought to combine with organophosphorus pesticides, mercury, arsenic, and other heavy metals, promoting the excretion of sediments from the body. Mung beans have been shown to possess antioxidant, antimicrobial, and anti-inflammatory activities. Moreover, mung beans have antidiabetic, antihypertensive, lipid metabolism accommodation, antihypertensive, and antitumor effects, among others.

A Review Article published in 2014 in the journal Evidence-Based Complementary and Alternative Medicine found that Honey proves to be an effective, cost-efficient treatment for diabetic wounds due to its natural properties, including antibacterial activity and control over inflammation. The researchers reviewed the role of honey in healing diabetic wounds, specifically focusing on its antibacterial properties. They examined the honey's ability to combat several microorganisms that are involved in the wound process, and assessed the extent of its antioxidant activity, which plays a key role in controlling inflammation. They also analyzed how honey was used in traditional medicine and compared it to its current resurgence in treating diabetic wounds. In their discussion of results, the researchers found that honey appears to work more effectively on diabetic wounds compared to other synthetic medications. The studies suggested that honey could be a safer, faster, and more economical healing agent for diabetic wounds due to its effectiveness against microbial resistance. Furthermore, honey's unique natural features as a wound healer demonstrated strong potential in the wound healing process, affirming its traditional claims.

A Experimental Study published in 2014 in the journal Evidence-Based Complementary and Alternative Medicine found that Honey, specifically its polyphenols, show promising signs of enhancing memory and counteracting neurodegenerative diseases by reducing oxidative stress and neuroinflammation. The research focuses on the analysis of the nootropic and neuropharmacological benefits of honey, with particular emphasis on its polyphenol constituents. Essentially, honey's nutritional and physiological effects on memory enhancement and various neurological activities have been examined. This study delves into the mechanistic approach in which honey, as a natural compound, can mitigate oxidative stress while enhancing the cellular antioxidant defense system - a cue to its potential role in neutralizing reactive oxygen species that have harmful effects on neurological health. The findings from the research suggest that honey and its polyphenols play a noteworthy role in neuronal health. They display a potential ability to improve memory deficits and other neurodegenerative diseases. In particular, honey polyphenols have been associated with apoptosis activities and the reduction of microglia-induced neuroinflammation. Furthermore, the direct involvement of these polyphenols in synaptic plasticity was found, which could have a substantial effect on the behavior-modulating neural circuitry. Overall, these findings indicate the possible therapeutic value of honey and its polyphenols on the health of the neurological system.

A Review Article published in 2013 in the journal Journal of Agricultural and Food Chemistry found that Recent phytochemical studies of jujube fruits have shed some light on their biological effects, such as the anticancer, anti-inflammatory, antiobesity, immunostimulating, antioxidant, hepatoprotective, and gastrointestinal protective activities and inhibition of foam cell formation in macrophages. The nutritional jujube (Ziziphus jujube Mill.) fruit belonging to the Rhamnaceous family grows mostly in Europe, southern and eastern Asia, and Australia, especially the inland region of northern China. Jujube has a long history of usage as a fruit and remedy. The main biologically active components are vitamin C, phenolics, flavonoids, triterpenic acids, and polysaccharides. Recent phytochemical studies of jujube fruits have shed some light on their biological effects, such as the anticancer, anti-inflammatory, antiobesity, immunostimulating, antioxidant, hepatoprotective, and gastrointestinal protective activities and inhibition of foam cell formation in macrophages. A stronger focus on clinical studies and phytochemical definition of jujube fruits will be essential for future research efforts. This review may be useful for predicting other medicinal uses and potential drug or food interactions and may be beneficial for people living where the jujube fruits are prevalent and health care resources are scarce.

A Experimental Study published in 2013 in the journal Evidence-Based Complementary and Alternative Medicine found that Pomegranate juice can enhance memory function and brain activity in tasks related to verbal and visual memory in older adults experiencing memory problems. The study was a preliminary, placebo-controlled, randomized trial involving 32 older participants with memory complaints. They were randomly tasked to consume 8 ounces of either pomegranate juice or a placebo drink that had a similar flavor daily for a duration of 4 weeks. Before and after the study duration, the subjects underwent memory tests and functional MRI scans while involved in cognitive tasks. Additionally, blood samples were extracted to ascertain peripheral biomarkers. The test subjects and investigators were oblivious to the groupings to ensure objectivity. The results from the study pointed out that the group that had pomegranate juice had notable improvements in their verbal memory as determined by the Buschke selective reminding test and also a rise in their antioxidant capacity. This group also recorded increased fMRI activity during tasks related to verbal and visual memory in comparison to the placebo group. This may suggest that consumption of pomegranate juice may boost memory function by elevating functional brain activity during tasks.

A Review Article published in 2012 in the journal Journal of Psychopharmacology found that Curcumin, a component of Indian spice turmeric, presents a potential natural treatment for depression, influencing neurotransmitters and protecting against several biological systems compromised in depression. The research methodology involved an extensive review of the varying influences and effects of curcumin on systems implicated in depression. These included neurotransmitter systems like serotonin and dopamine which are critical to mood regulation. The study also explored the effects of curcumin on hypothalamus-pituitary-adrenal disturbances, famously associated with stress response and mood disorders. In terms of results, curcumin demonstrated promising potential as an antidepressant in animal models of depression. Additionally, it was found to help moderate damage to neurological systems and intestinal permeability, both of which are often compromised in major depressive disorders. It also exhibited properties that could help lower inflammation and protect against oxidative stress and mitochondrial damage. Together, these findings position curcumin as a promising natural treatment for depression.

A Experimental Study published in 2012 in the journal Food Chemistry found that Adzuki bean exhibited the strongest antiproliferative properties in a dose-dependent manner against all digestive system cancer cell lines, ovary cancer cell SK-OV-3 and breast cancer cell MCF-7 among all legumes tested. This research involved comparing the health-promoting effects of various food legumes. The Cellular Antioxidant Activity (CAA) was assessed using a fluorescence microplate reader and in vitro animal cell cultivation. The antiproliferative properties against cancer cells were evaluated through the MTT method in an in vitro cell culture system. Additionally, the study quantified phytochemicals (total phenolic, procyanidin, saponin, and phytic acid) and chemical antioxidant activities (DPPH free radical scavenging activity, oxygen radical absorbing capacity, peroxyl radical scavenging capacity). The results indicated significant variations in phytochemical and antioxidant activities among different legumes. Notably, adzuki bean demonstrated the strongest dose-dependent antiproliferative effects against various cancer cell lines, including those from the digestive system, ovary, and breast. Meanwhile, black soybean showed the highest levels of saponin, phytic acid, and the strongest cellular antioxidant activities. These findings suggest that food legumes, particularly adzuki beans and black soybeans, are promising as natural antioxidants for health promotion and cancer prevention.

A Systematic Review published in 2011 in the journal Nutrition Journal found that These results suggest the possible antihypertensive effects of black sesame meal on improving antioxidant status and decreasing oxidant stress. This study suggests a beneficial effect of dietary black sesame meal on a reduction in blood pressure in pre-hypertensive humans. It is likely that the antihypertensive effect is due to decreased oxidative stress. Taken together with the absence of side effects and inexpensive preparation, the regular ingestion of dietary black sesame meal may be beneficial for CVD prevention in individuals with prehypertension, or even those with hypertension. A future study that investigates this advantageous effect is suggested.

A Randomised Controlled Trial published in 2011 in the journal Optometry and Vision Science found that Daily goji berry supplementation increases antioxidant levels and protects visual health in the elderly, though the exact mechanism remains unclear. In a double-masked, randomized, placebo-controlled study, elderly participants were given either a milk-based goji berry supplement (13.7 g/d) or a placebo for a 90-day period. Eye health was assessed via direct examination to measure pigmentation and soft drusen count in the macula, and blood tests were done to determine plasma zeaxanthin level and total antioxidant capacity. In the discussion of results, the placebo group showed signs of hypopigmentation and soft drusen accumulation in the macula, which did not occur in the group that received the goji berry supplement. The group supplementing with goji berries also showed a significant increase in plasma zeaxanthin levels and total antioxidant capacity, while no change was seen in the placebo group. There were no adverse effects of the supplement reported in either group.

A Clinical Study published in 2004 in the journal Clinical Nutrition found that Consumption of pomegranate juice by patients with carotid artery stenosis decreases carotid intima-media thickness and systolic blood pressure, potentially due to its strong antioxidant properties. The researchers investigated the effects of consuming pomegranate juice, enriched with potent tannins and anthocyanins, on carotid lesion progression, oxidative stress, and blood pressure in patients suffering from carotid artery stenosis. Over a period of 1-3 years, ten patients were supplemented with pomegranate juice, with blood samples collected before the treatment and during juice consumption. A control group, which did not consume pomegranate juice, was also monitored. The study revealed significant reduction in carotid intima-media thickness of up to 30% after a year of pomegranate juice consumption as compared to the control group that saw an increase of 9%. Pomegranate juice consumption was also associated with an 83% increase in the patients' serum paraoxonase 1 activity, and a significant reduction in serum LDL basal oxidative state and LDL susceptibility to copper ion-induced oxidation. Antibodies against oxidized LDL in serum levels were decreased by 19%, and total antioxidant status increased by 130%. Moreover, systolic blood pressure reduced by 12% after a year of juice consumption. Most notably, the maximal effects were observed after one year of juice consumption, with no additional significant beneficial impacts observed with further juice consumption over a span of three years.

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