Hypolipidemic
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Research Articles
Published research studies are articles that present the findings of original research that has undergone a peer-review process and has been made publicly available in scholarly journals, books or other media.
Extraction, structural-activity relationships, bioactivities, and application prospects of Pueraria lobata polysaccharides as ingredients for functional products: A review
2023 Jul International Journal of Biological Macromolecules Wang J, Dai G, Shang M, Wang Y, Xia C, Duan B, et al.
It was found that PLPs possess various bioactivities, including antioxidation, antidiabetic, immunomodulatory, hypolipidemic, antibacterial activities, regulation of intestinal flora, etc. The linkage patterns of glycosidic bonds might influence the bioactivities of PLPs. Meanwhile, PLPs have great development prospects in the health food and medical industries due to their non-toxicity. These discoveries establish a solid foundation for expanding the application and investigations of PLPs.
Review Article
The hypolipidemic mechanism of chrysanthemum flavonoids and its main components, luteolin and luteoloside, based on the gene expression profile
2022 Sep 06 Frontiers in Nutrition Sun J, Wang Z, Lin C, Xia H, Yang L, Wang S, et al.
Chrysanthemum flavonoids (CF) exhibited 41 differential genes, including Sqle, Gck, and Idi1, associated with cholesterol and fatty acid metabolism, and glycolysis; luteolin intervention primarily influenced the synthesis and transport of cholesterol with 68 differential genes, including Acsl3, Cyp7a1, and Lpin1; while luteoloside intervention showed 51 differential genes, including Acaca, Cyp7a1, and Lpin1, mainly associated with fatty acid metabolism. The study highlights the complexity of CF's mechanism in improving hyperlipidemia, suggesting distinct pathways compared to luteolin and luteoloside, necessitating further investigation into the roles of other components.
Experimental Study Luteolin Luteoloside
Mechanistic insights on burdock (Arctium lappa L.) extract effects on diabetes mellitus
2022 Apr 25 Food Science and Biotechnology Mondal SC, Eun JB
In conclusion, the active ingredients (isolated from different parts of the plant) found in burdock have been shown to be effective in treating a wide variety of conditions and numerous in vitro and in vivo evidences have suggested that A. lappa extract has the potential to impart therapeutic effect in diabetes due to the phytochemical content. Evidences also showed that burdock (A. lappa) extract contains inulin-type fructooligosaccharides, bioactive compounds such as chlorogenic acid, caffeic acid and its derivatives, tannins, saponins etc. which may exert positively on muscle glucose transport and insulin sensitivity rather than only inhibit the enzymatic activities. In addition, studying the acute toxicity of burdock root also revealed no toxic effects, which means the consumption of phenolic and flavone containing burdock root in foods and beverages or extract would be beneficial in alleviating diabetic complications.
Review Article
Hypolipidemic effect of Sesame Seed Oil: A Review
2022 Apr 30 Pakistan BioMedical Journal Arshad M, Ashfaq M, Rizwan B, Zanib R, Fatima A, Pervaiz R, et al.
Sesame seed oil and its derivatives have shown to be highly effective in managing hyperlipidemia and dyslipidemia due to their lipid ameliorating and anti-oxidative effects.
Experimental Study Review Article Cholesterol Sesame Oil Hypercholesterolemia
Health Benefits of Coconut Water
2022 Jan Reference Series in Phytochemistry Rethinam P, Krishnakumar V
Review Article Alzheimer's DiseaseCoconut water possesses unique compound profiles that imbue it with a broad spectrum of medical properties, incorporating aspects of nutrition, pharmacology, and disease prevention.
Research Insights
Insights are moderated by the Research Hub team and offer an at-a-glance overview of interesting research findings.
Coconut water possesses unique compound profiles that imbue it with a broad spectrum of medical properties, incorporating aspects of nutrition, pharmacology, and disease prevention.
2022 Reference Series in Phytochemistry Health Benefits of Coconut Water Rethinam P, Krishnakumar V
Review Article Alzheimer's Disease
The study utilized comprehensive analysis to assess the chemical profile of coconut water, identifying a range of components including phytohormones, enzymes, antioxidant compounds, vitamins, minerals, and phenolic compounds. These components are known to contribute to the water's biological activity and pharmacological effects, thereby enabling a raft of medicinal properties inherent to coconut water. The water was found to feature anti-microbial, anti-bacterial, anti-inflammatory, anti-hypertensive, rejuvenating, hepatoprotective, hypolipidemic, and diuretic properties.
An examination of the therapeutic effects of coconut water revealed a significant impact on gastric dysfunction, dysentery, and child malnutrition alongside notable capabilities to manage hypertension. The water was found to promote exercise performance, reduce swelling, dissolve kidney stones, improve kidney function, improve digestion, relieve constipation, reduce the risk of heart disease, lower high blood pressure, and improve cholesterol levels. Consumption of tender coconut water was specifically found to reduce the risk of heart disease, help prevent Alzheimer’s disease pathologies and prevent osteoporosis in experimental animals. The unique nutritional profile of coconut water was also found to provide it with the capacity to balance body chemistry and fight cancer.
Tremella fuciformis polysaccharide, a major bioactive component in the edible medicinal mushroom, exhibits substantial health benefits, including enhancing the immune system, combatting tumors, and delaying aging.
2019 Progress in Molecular Biology and Translational Science Tremella polysaccharide: The molecular mechanisms of its drug action Yang D, Liu Y, Zhang L.
Network Pharmacology Snow Fungus
The study analyzed various fractions of Tremella fuciformis polysaccharide (TFPS) which is extracted from the "Yiner" mushroom under different conditions leading to variations in molecular weight. The TFPS comprises various monosaccharides including mannose, xylose, fucose, glucuronic acid, glucose, and galactose. One of the characterized structures consists of a linear mannose backbone with branched off chains of xylose, fucose and glucuronic acid. Biochemical, pharmacological, and clinical studies involving TFPS spanning 46 years (1972-2018) were drawn from the likes of PubMed, China National Knowledge Infrastructure and Wanfang database and comprehensively reviewed.
Over one hundred independent studies pointed to the multiple physiological and health-promoting effects of TFPS. These include benefits such as immunomodulation, antitumor, anti-oxidation, anti-aging, hypoglycemic, and hypolipidemic effects. An example of its practical application is its usage in enteric-coated capsules, approved by the Chinese Food and Drug Administration in 2002, to treat cancer patients suffering from leukopenia induced by chemotherapy and radiotherapy. This component is also used as a supplementary drug for the treatment of chronic persistent hepatitis and chronic active hepatitis, showing the versatility and progressive impact of TFPS.
Black pepper, beyond its culinary use, offers medicinal benefits like antimicrobial, antioxidant, anticancer, anti-diabetic, and anti-inflammatory properties mainly attributed to the compound piperine.
2019 Critical Reviews in Food Science and Nutrition A systematic review on black pepper (Piper nigrum L.): from folk uses to pharmacological applications Takooree H, Aumeeruddy MZ, Rengasamy KRR, Venugopala KN, Jeewon R, Zengin G, et al.
Systematic Review Black Pepper
The study was a systematic review of existing scientific data on the traditional uses, composition, and pharmacological attributes of black pepper. Information was gathered from recognized databases such as Science Direct and Google Scholar, as well as books and other online resources. The study primarily focused on literature in English and evaluated traditional medicinal uses of black pepper in various regions, the common ailments it was used to address, and the preferred modes of preparation.
The results of the study affirm the significant medicinal qualities of black pepper. Its antimicrobial activity was demonstrated against various pathogens, and it showed strong antioxidant effects against several reactive oxygen and nitrogen species. The research also highlighted the anticancer effects of black pepper on cell lines from various sites including breast, colon, cervix, and prostate. Furthermore, the benefits of black pepper in managing diabetes and lipid levels in the body were also confirmed. It was also noted for its anti-inflammatory, analgesic, anticonvulsant, and neuroprotective effects. Piperine was identified as the major bioactive compound in black pepper which is responsible for these beneficial effects along with other compounds such as piperic acid, piperlonguminine, and more.
A mixture of active polysaccharides from Goji berries have shown multiple pharmacological activities, including anti-aging, antioxidative, anti-fatigue, anticancer, anti-diabetic, anti-viral, hepatoprotective, cardioprotective, neuroprotective, hypolipidemic, radioprotective, anti-osteoporosis, anti-inflammatory, and immunomodulating effects.
2014 Drug Design, Development and Therapy An evidence-based update on the pharmacological activities and possible molecular targets of Lycium barbarum polysaccharides Cheng J, Zhou Z, Sheng H, He L, Fan X, He Z, et al.
Review Article
The mechanisms for these beneficial effects are multifaceted, involving a number of signaling molecules and pathways. A better understanding of how LBPs act on these signaling pathways and molecules can improve our knowledge on glycobiology. Further studies using systems pharmacology approaches such as proteomic and metabolomic analysis are needed to uncover the molecular target networks of LBPs.
Despite the importance of Goji in the traditional Chinese medicine and increased popularity in Western countries, clinical safety data on LBPs are sparse. A safe and optimal use of herbal medicines like LBPs requires a full understanding of their pharmacokinetics, side effects, and mechanisms of action. The dose–response and dose–toxicity relationships of LBPs should be established in animal and human studies. It is essential to develop new formulations to ensure the maximum efficacy and effectiveness and minimum side effects of LBP-related health products.
Pomegranate juice intake for two weeks significantly reduces blood pressure and may improve heart health by lowering vascular endothelial adhesion molecule-1 levels.
2013 Phytotherapy Research Clinical Evaluation of Blood Pressure Lowering, Endothelial Function Improving, Hypolipidemic and Anti‐Inflammatory Effects of Pomegranate Juice in Hypertensive Subjects Asgary S, Sahebkar A, Afshani MR, Keshvari M, Haghjooyjavanmard S, Rafieian‐Kopaei M
Clinical Study
In the experiment, twenty-one hypertensive participants, aged between 30 to 67 years, were gathered and randomly assigned to consume either 150ml of fresh pomegranate juice per day or an equal quantity of water for a period of two weeks. The pomegranate juice was consumed in a single occasion between lunch and dinner. The blood pressure of these subjects, including systolic and diastolic pressures, were measured before and after the trial period. Additionally, levels of specific elements including lipid profile parameters, apolipoproteins A and B, intracellular adhesion molecule-1, vascular endothelial adhesion molecule 1, E-selectin, and other inflammatory and endothelial function biomarkers such as high-sensitivity C-reactive protein and interleukin-6, were also measured.
The results showed that the consumption of pomegranate juice was associated with notable reductions in both systolic and diastolic blood pressures. The intake of pomegranate juice also resulted in a significant decrease in levels of vascular endothelial adhesion molecule 1, even though there was an increase in E-selectin levels. No observable influence appeared on the levels of intracellular adhesion molecule-1, high-sensitivity C-reactive protein, lipid profile parameters, apolipoproteins, or interleukin-6 from the juice consumption, indicating that pomegranate juice may specifically target certain elements related to heart health.
Review Articles
Review articles summarise and critically evaluate the current state of research on a specific topic or field by synthesising multiple primary research studies.
Extraction, structural-activity relationships, bioactivities, and application prospects of Pueraria lobata polysaccharides as ingredients for functional products: A review
2023 Jul International Journal of Biological Macromolecules Wang J, Dai G, Shang M, Wang Y, Xia C, Duan B, et al.
It was found that PLPs possess various bioactivities, including antioxidation, antidiabetic, immunomodulatory, hypolipidemic, antibacterial activities, regulation of intestinal flora, etc. The linkage patterns of glycosidic bonds might influence the bioactivities of PLPs. Meanwhile, PLPs have great development prospects in the health food and medical industries due to their non-toxicity. These discoveries establish a solid foundation for expanding the application and investigations of PLPs.
Review ArticleMechanistic insights on burdock (Arctium lappa L.) extract effects on diabetes mellitus
2022 Apr 25 Food Science and Biotechnology Mondal SC, Eun JB
In conclusion, the active ingredients (isolated from different parts of the plant) found in burdock have been shown to be effective in treating a wide variety of conditions and numerous in vitro and in vivo evidences have suggested that A. lappa extract has the potential to impart therapeutic effect in diabetes due to the phytochemical content. Evidences also showed that burdock (A. lappa) extract contains inulin-type fructooligosaccharides, bioactive compounds such as chlorogenic acid, caffeic acid and its derivatives, tannins, saponins etc. which may exert positively on muscle glucose transport and insulin sensitivity rather than only inhibit the enzymatic activities. In addition, studying the acute toxicity of burdock root also revealed no toxic effects, which means the consumption of phenolic and flavone containing burdock root in foods and beverages or extract would be beneficial in alleviating diabetic complications.
Review ArticleHypolipidemic effect of Sesame Seed Oil: A Review
2022 Apr 30 Pakistan BioMedical Journal Arshad M, Ashfaq M, Rizwan B, Zanib R, Fatima A, Pervaiz R, et al.
Sesame seed oil and its derivatives have shown to be highly effective in managing hyperlipidemia and dyslipidemia due to their lipid ameliorating and anti-oxidative effects.
Experimental Study Review Article Cholesterol Sesame Oil HypercholesterolemiaHealth Benefits of Coconut Water
2022 Jan Reference Series in Phytochemistry Rethinam P, Krishnakumar V
Review Article Alzheimer's DiseaseCoconut water possesses unique compound profiles that imbue it with a broad spectrum of medical properties, incorporating aspects of nutrition, pharmacology, and disease prevention.
Traditional application and modern pharmacological research of Eucommia ulmoides Oliv.
2021 Aug 06 Chinese Medicine Huang L, Lyu Q, Zheng W, Yang Q, Cao G
In summary, extensive in vitro and in vivo data have revealed that E. ulmoides possess multiple excellent biological activities, including cardiovascular system regulation, anti-osteoporotic, anti-inflammatory, antioxidant, hypolipidemic, neuroprotective, hypoglycemic, anti-obesity, anti-diabetic, hepatoprotective and renal protective, anti-cancer, immunoregulation, improving erectile, anti-fatigue, anti-aging, anti-fungal, anti-bacterial, supporting the promising therapeutic application of E. ulmoides in various human diseases.
Review Article Du ZhongPresentation Slides
Coconut water possesses unique compound profiles that imbue it with a broad spectrum of medical properties, incorporating aspects of nutrition, pharmacology, and disease prevention.
Tremella fuciformis polysaccharide, a major bioactive component in the edible medicinal mushroom, exhibits substantial health benefits, including enhancing the immune system, combatting tumors, and delaying aging.
Black pepper, beyond its culinary use, offers medicinal benefits like antimicrobial, antioxidant, anticancer, anti-diabetic, and anti-inflammatory properties mainly attributed to the compound piperine.
A mixture of active polysaccharides from Goji berries have shown multiple pharmacological activities, including anti-aging, antioxidative, anti-fatigue, anticancer, anti-diabetic, anti-viral, hepatoprotective, cardioprotective, neuroprotective, hypolipidemic, radioprotective, anti-osteoporosis, anti-inflammatory, and immunomodulating effects.
Pomegranate juice intake for two weeks significantly reduces blood pressure and may improve heart health by lowering vascular endothelial adhesion molecule-1 levels.
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