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Modified Xiao Chai Hu Decoction combined with mirtazapine shows superior effectiveness in treating persistent depressive disorder compared to traditional Chinese medicine alone.
2022 Frontiers in Pharmacology Modified Xiaochaihu Decoction Combined with Mirtazapine in the Treatment of Persistent Depression: A Pilot Randomized Controlled Trial Xin Li, Xiuyu Li, Man Gong, Chaoqun Li, Jing Li, Chao Zhou, et al.
Randomised Controlled Trial Depression Mirtazapine Xiao Chai Hu Tang
For the study, patients from the Naval General Hospital diagnosed with persistent depressive disorder were selected and divided into two groups. One group received modified Xiaochaihu Decoction only, while the other group was treated with a combination of modified Xiaochaihu Decoction and mirtazapine. To track progress, measurements were taken using the self-rating depression scale and the traditional Chinese medicine scale at the beginning of treatment, and again after a period of 12 weeks. Moreover, an account of any adverse reactions was also kept.
The study results indicate the total effective rate was significantly higher in the combined group compared to the control group. It was also found that while post-treatment scores of the depression scales were lower in both groups, the difference between the groups was not statistically significant. However, the combined group reported higher improvement rates for symptoms like insomnia, bitter taste, languid, and belching/anorexia. An increased frequency of adverse events was also noted in the combined group.
Honey exhibits significant anti-Helicobacter pylori activity, with at least 10% concentration proving effective in inhibiting gastric and duodenal ulcers, highlighting its therapeutic potential.
2020 Sains Malaysiana In vitro Study of Anti-Helicobacter pylori Activity of Honey: A Systematic Review Adam Q, Annuar F, Alfizah H, Mohd Fahami NA
Systematic Review Gastritis H Pylori Honey
The research involved a comprehensive review of 53 articles from electronic databases such as Medline via Ovid Medline, Scopus, and ScienceDirect spanning from 2000 to 2018. Selection criteria focused on studies reporting honey's effects on H. pylori-induced gastric and duodenal ulcers. Nine chosen articles detailed the positive impact of honey, suggesting a minimum 10% concentration as effective against H. pylori. The review underscores the need for further exploration into honey's active components and molecular mechanisms.
The positive outcomes reported in selected studies support honey's potential in inhibiting H. pylori infections, emphasizing the need for further investigations to elucidate the active components and underlying molecular mechanisms. The review sets the stage for future research aiming to provide robust evidence for the use of honey in clinical settings.
Coconut water and milk demonstrate protective effects against ulceration, reducing inflammation, promoting cell proliferation and supporting mucosal homeostasis.
2017 Tissue and Cell Gastroprotective and mucosa homeostatic activities of coconut milk and water on experimentally induced gastropathies in male wistar rats Ajeigbe KO, Owonikoko WM, Egbe V, Iquere I, Adeleye G
Experimental Study Coconut Milk Coconut Water Stomach Ulcer
The study was conducted in two phases using 45 male wistar rats divided into 9 groups. The first phase involved treatment of five groups with different substances: normal saline, 95% ethanol, coconut water, coconut milk, and Omeprazole. Ulceration was induced with 95% ethanol except in the saline-control group. The second phase involved four groups: a control group, an ulcer control group receiving acetic acid, a group receiving coconut milk and another receiving Omeprazole. Drug treatments were administered twice daily for 3-6 days post-ulcer induction. Afterwards, blood was collected for haemocytometry and gastric tissues were harvested for histological examinations.
In this study, both coconut water and milk, as well as Omeprazole, led to reduced ulcer scores and gastric lesion indices compared to the ulcer control groups. They also resulted in significantly lower white blood cell, neutrophil, and lymphocyte counts compared to the ulcer and overall control groups. Coconut milk, in particular, was associated with a significant reduction in C-reactive protein. The experimental treatments also led to reduced neutrophil infiltration and an increase in mucus cell density. Notably, the coconut milk group showed significantly higher expressions of EGFR and CD31, indicating catalysis of mucosa homeostasis through angiogenesis and mucosal cell proliferation.
Peptic ulcers may be prevented and cured by well-chewed food rich in vegetable fibers and fermented milk products, which increase protective salivary mucus and decrease damaging bile flow.
1978 Psychoneuroendocrinology New approaches to the pathogenesis of peptic ulcer based on the protective action of saliva with special reference to roughage, vegetable fibre and fermented milk products Malhotra SL
Stomach Ulcer
The research conducted a review of epidemiologic studies focusing on the variations of diet and eating patterns related to the prevalence of peptic ulcer disease across various communities. The effects of dietary patterns were assessed on saliva, gastric juice, and bile. The role of bile was specifically examined in the pathogenesis of peptic ulcer, with the argument that it, rather than hydrochloric acid, played a causal role. The role of saliva in preventing peptic ulcers was emphasized, particularly the protective nature of salivary mucus which is swallowed with food.
The study then suggested the types of diets that can help prevent peptic ulcers, including those rich in roughage, cellulose, vegetable fibers, and fermented milk products such as ghee and yogurt. The research posited this kind of diet can increase the amount of salivary mucus and consequently decrease the flow rate of harmful bile. The study also noted that these insights showed minor changes in diet, and a slower pace of consumption could lead to substantial health benefits.
Moving from dietary composition to eating behaviors, it was suggested that food should be well-masticated to ensure these beneficial digestive processes have an opportunity to occur. At the same time, the research made the case that specific dietary components, particularly short-chain fatty acids like those found in milk products, can retard gall bladder contraction, thereby reducing the amount of bile entering the duodenal lumen. This secondary action further contributes to the potential prevention of peptic ulcers.